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Biomedicines
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The Role of the Immune System in Kidney Disease: Advances...
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The Role of the Immune System in Kidney Disease: Advances in Mechanisms and Therapeutics

A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Immunology and Immunotherapy".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 1985

Special Issue Editor

Dr. Hans-Kristian Lorenzo

E-Mail Website
Guest Editor
1. Department of Life of Sciences, Paul Brousse Hospital, Universite Paris-Saclay, 14 avenue Paul Vaillant Couturier, 94807 Villejuif, France
2. Bicêtre Hospital, Department of Nephrology, 78 Rue du Général Leclerc, 94270 Le Kremlin-Bicêtre, France
3. INSERM UMR 1197, 14 avenue Paul Vaillant Couturier, 94807 Villejuif, France
Interests: cell death; senescence; autophagy; DNA damage; stem cells; pathogenesis of renal disorder; molecular medicine; immunology of transplantation

Special Issue Information

Dear Colleagues,

The kidney is a vital organ with multiple functions for the organism, including the filtration of toxic substances from serum and the regulation of blood pressure or hematopoiesis. There is a very close relationship between the kidney and the immune system. It is well known that the immune system may be at the origin of many variants of kidney diseases, either directly or indirectly. For example, immune system dysregulation, involving the production of autoantibodies, is the cause of diseases, such as IgA glomerulopathies, lupus nephropathy, ANCA-associated vasculitis, or membranous nephropathy. In other cases, lymphocyte destabilization can secret the serum of circulating factors at the origin of glomerulopathies such as FSGS. Even more paradigmatic is the example of the immune response to renal transplantation, the control of which is one of the workhorses of nephrologists. In recent decades, much progress has been made in the mechanisms of the allogeneic response and immunosuppression, which has opened up new avenues of study with great therapeutic potential.

The aim of this Special Issue is to compile emerging research in the field of immunology related to kidney disease. The spectrum of studies is very broad, but always within the effects of the immune system on the kidney. In addition, therapeutic applications for the treatment of immune-mediated nephropathies, including those resulting from kidney transplantation, are welcomed.

Dr. Hans-Kristian Lorenzo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomedicines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • kidney transplantation
  • glomerulonephritis
  • fibrosis
  • immune homeostasis
  • inflammation
  • kidney disease

Published Papers (1 paper)

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Research

14 pages, 1619 KiB  
Article
Association between Psoriasis and Renal Functions: An Integration Study of Observational Study and Mendelian Randomization
by Yuxuan Tan, Zhizhuo Huang, Haiying Li, Huojie Yao, Yingyin Fu, Xiaomei Wu, Chuhang Lin, Zhengtian Lai, Guang Yang and Chunxia Jing
Biomedicines 2024, 12(1), 249; https://0-doi-org.brum.beds.ac.uk/10.3390/biomedicines12010249 - 22 Jan 2024
Viewed by 1687
Abstract
Psoriasis is an autoimmune-mediated disease with several comorbidities in addition to typical skin lesions. Increasing evidence shows the relationships between psoriasis and renal functions, but the relationship and causality remain unclear. We aimed to investigate the associations and causality between psoriasis and four [...] Read more.
Psoriasis is an autoimmune-mediated disease with several comorbidities in addition to typical skin lesions. Increasing evidence shows the relationships between psoriasis and renal functions, but the relationship and causality remain unclear. We aimed to investigate the associations and causality between psoriasis and four renal functions, including the estimated glomerular filtration rate (eGFR), blood urea nitrogen (BUN), urine albumin to creatinine ratio (UACR), and chronic kidney disease (CKD). For the population-based study, we analyzed the National Health and Nutrition Examination Survey (NHANES) data from five cycles (2003–2006 and 2009–2014) on psoriasis and renal functions. Subgroup analyses were conducted among different categories of participants. Meanwhile, a bidirectional two-sample Mendelian randomization (TSMR) study in European populations was also performed using summary-level genetic datasets. Causal effects were derived by conducting an inverse-variance weighted (MR-IVW) method. A series of pleiotropy-robust MR methods was employed to validate the robustness. Multivariable MR (MVMR) was conducted to complement the result when five competing risk factors were considered. A total of 20,244 participants were enrolled in the cross-sectional study, where 2.6% of them had psoriasis. In the fully adjusted model, participants with psoriasis had significantly lower eGFR (p = 0.025) compared with the healthy group. Individuals who are nonoverweight are more likely to be affected by psoriasis, leading to an elevation of BUN (Pint = 0.018). In the same line, TSMR showed a negative association between psoriasis and eGFR (p = 0.016), and sensitive analysis also consolidated the finding. No causality was identified between psoriasis and other renal functions, as well as the inverse causality (p > 0.05). The MVMR method further provided quite consistent results when adjusting five confounders (p = 0.042). We detected a significant negative effect of psoriasis on eGFR, with marginal association between BUN, UACR, and CKD. The adverse of psoriasis on the renal should merit further attention in clinical cares. Full article
(This article belongs to the Special Issue The Role of the Immune System in Kidney Disease: Advances in Mechanisms and Therapeutics)
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