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Biosensors
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Biosensors for Multiplex Detection of Biomarkers of Inflammatory Disease
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Biosensors for Multiplex Detection of Biomarkers of Inflammatory Disease

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensors and Healthcare".

Deadline for manuscript submissions: closed (20 March 2022) | Viewed by 12195

Special Issue Editor

Prof. Dr. Ali Mobasheri

E-Mail Website
Guest Editor
Musculoskeletal Biology, Research Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, P.O. Box 5000, FI-90014 Oulu, Finland
Interests: cartilage biology; chondrocyte physiology; proteomic and metabolomic studies on the secretome of articular cartilage, meniscus and synovium from animal models and identification of novel biomarkers of osteoarthritis (OA) in cohorts of OA patients, military personnel with OA and in individuals with joint injuries sustained in sport; immunometabolism in chondrocytes and mesenchymal stem cells; glucose and amino acid metabolism in articular cartilage; functional and molecular characterisation of ion channels and receptors involved in mechanosensing and mechanotransduction in chondrocytes; expression and functional regulation of the channelome in chondrocytes in inflammatory models of cartilage degradation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is dedicated to the topic of biosensors for the multiplex detection of biomarkers of inflammatory diseases. These may include any biomarker that is detectable in a biological sample or body fluid in a clinical setting. Papers may include in vitro studies and studies on preclinical animals, translational models and human patients. Studies on biosensors for the detection and quantification of any cell- or tissue-derived biomarker will be considered. Studies on biosensors of viral disease will also be considered.

Prof. Dr. Ali Mobasheri
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • sensor 
  • biosensor 
  • nanobiosensor 
  • multiplexing 
  • diagnostic 
  • immunoassay 
  • nanotechnology 
  • nanobiosensors 
  • quantum dots

Published Papers (4 papers)

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Editorial

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2 pages, 152 KiB  
Editorial
Biosensors for the Multiplex Detection of Inflammatory Disease Biomarkers
by Ali Mobasheri
Biosensors 2021, 11(1), 11; https://0-doi-org.brum.beds.ac.uk/10.3390/bios11010011 - 28 Dec 2020
Cited by 4 | Viewed by 2344
Abstract
A biosensor is an analytical device used for the real-time detection and measurement of a chemical or biochemical substance [...] Full article
(This article belongs to the Special Issue Biosensors for Multiplex Detection of Biomarkers of Inflammatory Disease)
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Research

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12 pages, 2107 KiB  
Article
Native T1 Mapping and Magnetization Transfer Imaging in Grading Bowel Fibrosis in Crohn’s Disease: A Comparative Animal Study
by Baolan Lu, Jinjiang Lin, Jinfang Du, Shaofu He, Qinghua Cao, Li Huang, Ren Mao, Canhui Sun, Ziping Li, Shiting Feng and Xuehua Li
Biosensors 2021, 11(9), 302; https://0-doi-org.brum.beds.ac.uk/10.3390/bios11090302 - 28 Aug 2021
Cited by 10 | Viewed by 1941
Abstract
In this study, we investigated the utility of native T1 mapping in differentiating between various grades of fibrosis and compared its diagnostic accuracy to magnetization transfer imaging (MTI) in a rat model of CD. Bowel specimens (64) from 46 CD model rats [...] Read more.
In this study, we investigated the utility of native T1 mapping in differentiating between various grades of fibrosis and compared its diagnostic accuracy to magnetization transfer imaging (MTI) in a rat model of CD. Bowel specimens (64) from 46 CD model rats undergoing native T1 mapping and MTI were enrolled. The longitudinal relaxation time (T1 value) and normalized magnetization transfer ratio (MTR) were compared between none-to-mild and moderate-to-severe fibrotic bowel walls confirmed by pathological assessments. The results showed that the correlation between the T1 value and fibrosis (r = 0.438, p < 0.001) was lower than that between the normalized MTR and fibrosis (r = 0.623, p < 0.001). Overall, the T1 values (t = −3.066, p = 0.004) and normalized MTRs (z = 0.081, p < 0.001) in none-to-mild fibrotic bowel walls were lower than those in moderate-to-severe fibrotic bowel walls. The area under the curve (AUC) of the T1 value (AUC = 0.716, p = 0.004) was significantly lower than that of the normalized MTR (AUC = 0.881, p < 0.001) in differentiating moderate-to-severe fibrosis from none-to-mild fibrosis (z = −2.037, p = 0.042). Our results support the view that the T1 value could be a promising imaging biomarker in grading the fibrosis severity of CD. However, the diagnostic performance of native T1 mapping was not superior to MTI. Full article
(This article belongs to the Special Issue Biosensors for Multiplex Detection of Biomarkers of Inflammatory Disease)
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12 pages, 3079 KiB  
Article
Duplex On-Site Detection of Vibrio cholerae and Vibrio vulnificus by Recombinase Polymerase Amplification and Three-Segment Lateral Flow Strips
by Pei Wang, Lei Liao, Chao Ma, Xue Zhang, Junwei Yu, Longyu Yi, Xin Liu, Hui Shen, Song Gao and Qunwei Lu
Biosensors 2021, 11(5), 151; https://0-doi-org.brum.beds.ac.uk/10.3390/bios11050151 - 12 May 2021
Cited by 18 | Viewed by 3341
Abstract
Vibrio cholerae and Vibrio vulnificus are two most reported foodborne Vibrio pathogens related to seafood. Due to global ocean warming and an increase in seafood consumption worldwide, foodborne illnesses related to infection of these two bacteria are growing, leading to food safety issues [...] Read more.
Vibrio cholerae and Vibrio vulnificus are two most reported foodborne Vibrio pathogens related to seafood. Due to global ocean warming and an increase in seafood consumption worldwide, foodborne illnesses related to infection of these two bacteria are growing, leading to food safety issues and economic consequences. Molecular detection methods targeting species-specific genes are effective tools in the fight against bacterial infections for food safety. In this study, a duplex detection biosensor based on isothermal recombinase polymerase amplification (RPA) and a three-segment lateral flow strip (LFS) has been established. The biosensor used lolB gene of Vibrio cholerae and empV gene of Vibrio vulnificus as the detection markers based on previous reports. A duplex RPA reaction for both targets were constructed, and two chemical labels, FITC and DIG, of the amplification products were carefully tested for effective and accurate visualization on the strip. The biosensor demonstrated good specificity and achieved a sensitivity of 101 copies per reaction or one colony forming unit (CFU)/10 g of spiked food for both bacteria. Validation with clinical samples showed results consistent with that of real-time polymerase chain reaction. The detection process was simple and fast with a 30-min reaction at 37 °C and visualization on the strip within 5 min. With little dependence on laboratory settings, this biosensor was suitable for on-site detection, and the duplex system enabled simultaneous detection of the two important foodborne bacteria. Moreover, the principle can be extended to healthcare and food safety applications for other pathogens. Full article
(This article belongs to the Special Issue Biosensors for Multiplex Detection of Biomarkers of Inflammatory Disease)
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Review

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36 pages, 1355 KiB  
Review
Graphene-Based Biosensors for Molecular Chronic Inflammatory Disease Biomarker Detection
by Isidro Badillo-Ramírez, Yojana J. P. Carreón, Claudia Rodríguez-Almazán, Claudia M. Medina-Durán, Selene R. Islas and José M. Saniger
Biosensors 2022, 12(4), 244; https://0-doi-org.brum.beds.ac.uk/10.3390/bios12040244 - 14 Apr 2022
Cited by 8 | Viewed by 3654
Abstract
Chronic inflammatory diseases, such as cancer, diabetes mellitus, stroke, ischemic heart diseases, neurodegenerative conditions, and COVID-19 have had a high number of deaths worldwide in recent years. The accurate detection of the biomarkers for chronic inflammatory diseases can significantly improve diagnosis, as well [...] Read more.
Chronic inflammatory diseases, such as cancer, diabetes mellitus, stroke, ischemic heart diseases, neurodegenerative conditions, and COVID-19 have had a high number of deaths worldwide in recent years. The accurate detection of the biomarkers for chronic inflammatory diseases can significantly improve diagnosis, as well as therapy and clinical care in patients. Graphene derivative materials (GDMs), such as pristine graphene (G), graphene oxide (GO), and reduced graphene oxide (rGO), have shown tremendous benefits for biosensing and in the development of novel biosensor devices. GDMs exhibit excellent chemical, electrical and mechanical properties, good biocompatibility, and the facility of surface modification for biomolecular recognition, opening new opportunities for simple, accurate, and sensitive detection of biomarkers. This review shows the recent advances, properties, and potentialities of GDMs for developing robust biosensors. We show the main electrochemical and optical-sensing methods based on GDMs, as well as their design and manufacture in order to integrate them into robust, wearable, remote, and smart biosensors devices. We also describe the current application of such methods and technologies for the biosensing of chronic disease biomarkers. We also describe the current application of such methods and technologies for the biosensing of chronic disease biomarkers with improved sensitivity, reaching limits of detection from the nano to atto range concentration. Full article
(This article belongs to the Special Issue Biosensors for Multiplex Detection of Biomarkers of Inflammatory Disease)
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