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Catalysts
Special Issues
Hybrid Nanozymes: From Concept to Biomedical Applications
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Hybrid Nanozymes: From Concept to Biomedical Applications

A special issue of Catalysts (ISSN 2073-4344). This special issue belongs to the section "Biocatalysis".

Deadline for manuscript submissions: closed (15 December 2022) | Viewed by 3533

Special Issue Editor

Prof. Dr. Ningning Song

E-Mail Website
Guest Editor
Experimental Center of Advanced Materials, School of Materials Science & Engineering, Beijing Institute of Technology, Beijing 100081, China
Interests: carbon-based nanozymes; nanocomposites; nanomanufacturing, nanostructures; biosensors; antibacterial

Special Issue Information

Dear Colleagues,

Nanozymes are an array of novel nanomaterials with catalytic activity and enzymatic reaction kinetics. Since their discovery, their remarkable properties have attracted attention. Compared with natural enzymes, they possess many advantages, such as inherent nanomaterial characteristics, a high catalytic stability, a low cost, feasible mass production, and robustness to harsh environments. At present, the major challenge in the practical implementation of nanozymes resides in their limited types and poor substrate selectivity; therefore, intensive efforts have been devoted to the rational design and engineering of hybrid nanozymes. For example, the catalytic performance of nanozymes can be modified by adjusting their size, shape, composition, and structure; a multifunctional catalytic system can be obtained through hierarchical structure design and and/or multi-component fabrication. Coupling with biological molecules can improve biocompatibility and achieve novel properties.

In this Special Issue, we would like to collect publications describing the concepts, catalytic mechanisms, and applications of hybrid nanozymes with a hierarchical structure and/or multiple components.

Submit your paper and select the Journal “Catalysts” and the Special Issue “Hybrid Nanozymes: From Concept to Biomedical Applications” via: MDPI submission system. Please contact the Guest Editor or the journal editor ([email protected]) for any queries. Our papers will be published on a rolling basis and we will be pleased to receive your submission once you have finished it.

Prof. Dr. Ningning Song
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Catalysts is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanozymes
  • nanomaterials
  • ligand modification
  • hierarchical structure
  • hybrid materials
  • cascade catalysis
  • biosensors
  • tumor therapy
  • antibacterial

Published Papers (2 papers)

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Research

10 pages, 1318 KiB  
Article
Multifunctional Hybrid Nanozymes for Magnetic Enrichment and Bioelectrocatalytic Sensing of Circulating Tumor RNA during Minimal Residual Disease Monitoring
by Kevin M. Koo
Catalysts 2023, 13(1), 178; https://0-doi-org.brum.beds.ac.uk/10.3390/catal13010178 - 12 Jan 2023
Cited by 1 | Viewed by 1378
Abstract
Iron oxide nanozymes are a form of nanomaterial with both superparamagnetic and enzyme-mimicking properties. Ongoing research efforts have been made to create multifunctional iron oxide hybrid nanozymes with auxiliary properties through biomolecular modifications. Such iron oxide hybrid nanozymes can be useful for rapid [...] Read more.
Iron oxide nanozymes are a form of nanomaterial with both superparamagnetic and enzyme-mimicking properties. Ongoing research efforts have been made to create multifunctional iron oxide hybrid nanozymes with auxiliary properties through biomolecular modifications. Such iron oxide hybrid nanozymes can be useful for rapid and cost-effective analysis of circulating tumor nucleic acids (ctNAs) in patient liquid biopsies during minimal residual disease (MRD) monitoring of cancer recurrence. Herein, the use of streptavidin-modified iron oxide hybrid nanozymes is reported for magnetic enrichment and bioelectrocatalytic sensing of three prostate cancer (PCa) ctRNA biomarkers with high detection specificity and sensitivity (10 copies) over an ultrabroad dynamic range (five orders of magnitude). Furthermore, the feasibility of ctRNA analysis for pre- and post-cancer treatment MRD monitoring is demonstrated using PCa urinary liquid biopsy samples. Full article
(This article belongs to the Special Issue Hybrid Nanozymes: From Concept to Biomedical Applications)
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20 pages, 5963 KiB  
Article
Decorating Zirconium on Graphene Oxide to Design a Multifunctional Nanozyme for Eco-Friendly Detection of Hydrogen Peroxide
by Ayesha Saleem Siddiqui, Muhammad Ashfaq Ahmad, Mian Hasnain Nawaz, Akhtar Hayat and Muhammad Nasir
Catalysts 2022, 12(10), 1105; https://0-doi-org.brum.beds.ac.uk/10.3390/catal12101105 - 25 Sep 2022
Cited by 2 | Viewed by 1707
Abstract
Peroxidase enzymes are crucial in analytical chemistry owing to significant peroxide analytes and their key role in hydrogen peroxide (H2O2) detection. Therefore, exploiting appropriate catalysts for the peroxidase like reactions has become crucial for achieving desired analytical performance. Zirconium [...] Read more.
Peroxidase enzymes are crucial in analytical chemistry owing to significant peroxide analytes and their key role in hydrogen peroxide (H2O2) detection. Therefore, exploiting appropriate catalysts for the peroxidase like reactions has become crucial for achieving desired analytical performance. Zirconium (Zr) has attracted growing interest, as a safe and stable potential eco-friendly catalyst for various organic transformations that address increasing environmental challenges. Hence, aiming at fast, sensitive and selective optical detection of H2O2, a colorimetric platform is presented here, based on the excellent peroxidase enzyme-like activity of Zr decorated on graphene oxide (GO). The synergistic effect achieved due to intimate contact between an enzyme like Zr and the high surface area 0f GO ensures efficient electron transfer that increases the chemical and catalytic activity of the composite and advances the decomposition of H2O2 into hydroxyl radicals. The designed probe, thus, efficiently catalyzes the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB), via hydroxyl radicals, thereby transforming the colorless TMB into blue oxidized TMB within 2 min. The catalytic mechanism of the Zr-GO enzyme mimic is proposed herein and verified using a fluorescent probe terephthalic acid (TA) and other scavenger experiments. The multifunctional optical probe allows sensitive and highly selective recognition of H2O2 in a linear range from 100 to 1000 µM with a low detection limit of 0.57 µM. Essentially, the direct accessibility of Zr prevents having to use the complicated preparation and purification procedures mostly practiced for conventional biozymes and nanozymes. The devised method offers several gains, including being green and an inexpensive catalyst, having lower LOD, being fast, cost-effective and sensitive, and having selective work-up procedures. Full article
(This article belongs to the Special Issue Hybrid Nanozymes: From Concept to Biomedical Applications)
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