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Catalytic Organic Transformations/Organic Synthesis

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A special issue of Catalysts (ISSN 2073-4344). This special issue belongs to the section "Catalysis in Organic and Polymer Chemistry".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 15251

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Special Issue Editors

Prof. Dr. Jae-Sang Ryu

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Guest Editor

College of Pharmacy & Graduate School of Pharmaceutical Sciences, Ewha Womans University, 52 Ewhayeodae-gil, Seodaemun-Gu, Seoul 03760, Korea
Interests: transition-metal catalysis; asymmetric catalysis; total synthesis; diversity-oriented synthesis; heterocyclic chemistry; medicinal chemistry; drug conjugate

Prof. Dr. Bimal Krishna Banik

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Guest Editor

Department of Mathematics and Natural Sciences, College of Sciences and Human Studies, Prince Mohammad Bin Fahd University, Al Khobar 31952, Saudi Arabia
Interests: organic synthesis; medicinal chemistry; cancer; green chemistry; microwave; drug discovery; natural product synthesis; mechanism of chemical and biological processes; interdisciplinary sciences
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Special Issue Information

Dear Colleagues,

In the domain of synthetic organic chemistry, catalysts play a crucial role in the synthesis of new molecules of diverse interests. A vast array of researchers involves exploring the molecules that stimulate organic transformations. The scope of catalysis in chemistry is reasonably comprehensive. The term catalysis was first proposed by Jöns Jakob Berzelius in 1835. Since its inception, Paul Sabatier discovered that a trace amount of Nickle metal can assist the addition of hydrogen to olefinic bond. This remarkable discovery revolutionized the field of catalysis. Over the past several decades, huge efforts have been devoted to establishing the utility of the wide range of metal, non-metal, and small organic molecules in triggering organic transformations exhaustively. Despite the spectacular successes in the catalysis process, innovative catalytic systems are highly demanding.

In this regard, this Special Issue on “Catalytic Organic Transformations/Organic Synthesis” offers an opportunity to researchers to submit their scientific output. Review articles, original research manuscripts, and communication articles featuring the role of catalysts in the following domain will be considered: (i) biocatalysts in organic synthesis; (ii) molecular catalysis in the synthesis of bioactive molecules; (iii) transition-metal-catalyzed synthesis and green synthesis in organic and medicinal chemistry; (iv) (heterogeneous) photocatalysis; and (v) metal-salts-catalyzed reactions.

Prof. Dr. Jae-Sang Ryu
Prof. Dr. Bimal Krishna Banik
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Catalysts is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

metal catalysis
green synthesis
natural products
medicinal chemistry
hetero and carbocyclic chemistry
organocatalysis
stereoselective synthesis

Published Papers (5 papers)

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Research

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14 pages, 10327 KiB

Open AccessFeature PaperArticle

Gold(I)-Catalyzed Tandem Synthesis of Polycyclic Dihydroquinazolinones

by Jingyang Sun, Yoona Song and Jae-Sang Ryu

Catalysts 2021, 11(12), 1436; https://0-doi-org.brum.beds.ac.uk/10.3390/catal11121436 - 25 Nov 2021

Cited by 2 | Viewed by 1706

Abstract

A gold-catalyzed cascade process for the synthesis of dihydroquinazolinone scaffolds was developed. A series of gold catalysts were screened for this tandem transformation, and the (PPh₃)AuCl/AgOTf catalyst combination was found to be the best catalyst system. This method is characterized by good yields, high regioselectivity, and broad substrate scope. This method is also applicable to the synthesis of tetracyclic dihydroquinazolinones and seven-membered ring-fused dihydroquinazolinones. Full article

(This article belongs to the Special Issue Catalytic Organic Transformations/Organic Synthesis)

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13 pages, 2965 KiB

Open AccessArticle

The Efficient Recyclable Molybdenum- and Tungsten-Promoted Mesoporous ZrO₂ Catalysts for Aminolysis of Epoxides

by Xolani Sibusiso Hlatshwayo, Morena S. Xaba, Matumuene Joe Ndolomingo, Ndzondelelo Bingwa and Reinout Meijboom

Catalysts 2021, 11(6), 673; https://0-doi-org.brum.beds.ac.uk/10.3390/catal11060673 - 25 May 2021

Cited by 1 | Viewed by 1979

Abstract

In the present study, we report the synthesis and catalytic activity of tungsten- and molybdenum-promoted mesoporous metal oxides in the aminolysis of epoxides. The as-synthesized catalysts were fully characterized by a variety of techniques such as transmission electron microscopy (TEM), scanning electron microscopy (SEM), temperature-programmed reduction (TPR) and desorption (TPD), nitrogen sorption measurements, powder X-ray diffraction (p-XRD), and thermogravimetric analysis (TGA). Amongst the two supports utilized, ZrO₂ is a better support compared to SiO₂. Furthermore, MoO₃ proved to be a better dopant compared to its counterpart. Several parameters such as the variation of solvents, substrates, catalyst amounts, and stirring speed were investigated. It was observed that 450 rpm was the optimum stirring speed, with toluene as the best solvent and styrene oxide as the best substrate. Moreover, the optimum parameters afforded 98% conversion with 95% selectivity towards 2-phenyl-2-(phenylamino) ethanol and 5% towards 1-phenyl-2-(phenylamino) ethanol. Furthermore, 5%MoO₃-ZrO₂ catalyst demonstrated optimal performance and it exhibited excellent activity as well as great stability after being recycled 6 times. Full article

(This article belongs to the Special Issue Catalytic Organic Transformations/Organic Synthesis)

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Review

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26 pages, 5598 KiB

Open AccessReview

Samarium-Mediated Asymmetric Synthesis

by Suman Majee, Devalina Ray and Bimal Krishna Banik

Catalysts 2023, 13(1), 24; https://0-doi-org.brum.beds.ac.uk/10.3390/catal13010024 - 24 Dec 2022

Cited by 1 | Viewed by 1547

Abstract

Samarium is an efficient reducing agent, a radical generator in cyclization and a cascade addition reaction. Interestingly, samarium metal has crucial impact on numerous C-C and C-X (X = hetero atom) bond forming transformations. It has been established as an exceptional chemo-selective and stereoselective reagent. The reactivity of the samarium catalyst/reagent is remarkably enhanced in the presence of various additives, ligands and solvents through effective coordination and an increase in reduction potential. It has inherent character to act as electron donor for a wide range of transformations including the asymmetric version of various reactions. This review accentuates the developments in samarium-mediated/catalyzed asymmetric organic synthesis over the past 12 years, where the chirality has been induced from ligand, a nearby asymmetric center within the substrate or through coordination directed stereospecific reactions. Full article

(This article belongs to the Special Issue Catalytic Organic Transformations/Organic Synthesis)

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Scheme 1

47 pages, 19049 KiB

Open AccessReview

Regiodivergent Organocatalytic Reactions

by Mayavan Viji, Srinu Lanka, Jaeuk Sim, Chanhyun Jung, Heesoon Lee, Manjunatha Vishwanath and Jae-Kyung Jung

Catalysts 2021, 11(8), 1013; https://0-doi-org.brum.beds.ac.uk/10.3390/catal11081013 - 22 Aug 2021

Cited by 21 | Viewed by 3976

Abstract

Organocatalysts are abundantly used for various transformations, particularly to obtain highly enantio- and diastereomeric pure products by controlling the stereochemistry. These applications of organocatalysts have been the topic of several reviews. Organocatalysts have emerged as one of the very essential areas of research due to their mild reaction conditions, cost-effective nature, non-toxicity, and environmentally benign approach that obviates the need for transition metal catalysts and other toxic reagents. Various types of organocatalysts including amine catalysts, Brønsted acids, and Lewis bases such as N-heterocyclic carbene (NHC) catalysts, cinchona alkaloids, 4-dimethylaminopyridine (DMAP), and hydrogen bond-donating catalysts, have gained renewed interest because of their regioselectivity. In this review, we present recent advances in regiodivergent reactions that are governed by organocatalysts. Additionally, we briefly discuss the reaction pathways of achieving regiodivergent products by changes in conditions such as solvents, additives, or the temperature. Full article

(This article belongs to the Special Issue Catalytic Organic Transformations/Organic Synthesis)

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47 pages, 24623 KiB

Open AccessReview

Asymmetric Catalytic Ketimine Mannich Reactions and Related Transformations

by Changgong Xu, Carlyn Reep, Jamielyn Jarvis, Brandon Naumann, Burjor Captain and Norito Takenaka

Catalysts 2021, 11(6), 712; https://0-doi-org.brum.beds.ac.uk/10.3390/catal11060712 - 07 Jun 2021

Cited by 17 | Viewed by 4890

Abstract

The catalytic enantioselective ketimine Mannich and its related reactions provide direct access to chiral building blocks bearing an α-tertiary amine stereogenic center, a ubiquitous structural motif in nature. Although ketimines are often viewed as challenging electrophiles, various approaches/strategies to circumvent or overcome the adverse properties of ketimines have been developed for these transformations. This review showcases the selected examples that highlight the benefits and utilities of various ketimines and remaining challenges associated with them in the context of Mannich, allylation, and aza-Morita–Baylis–Hillman reactions as well as their variants. Full article

(This article belongs to the Special Issue Catalytic Organic Transformations/Organic Synthesis)

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