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Cells
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The Role of Immune Cells in Ocular Diseases
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The Role of Immune Cells in Ocular Diseases

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 1538

Special Issue Editor

Dr. Malihe Eskandarpour

E-Mail Website
Guest Editor
UCL Institute of Ophthalmology, University College London, 11-43 Bath Street, London EC1V 9EL, UK
Interests: inflammation; ocular inflammatory diseases; immune privilege; innate immunity; adaptive immunity; tissue homeostasis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The eye and immune systems use strategies to maintain the ocular immune privilege by regulating the innate and adaptive immune responses, which include immunological ignorance, peripheral tolerance to eye-derived antigens, and the intraocular immunosuppressive microenvironment. Resident immune cells play an important role in local immunological homeostasis, and their responses can be protective or reparative. Local and systemic inflammatory and immune-mediated disorders affecting the eye are propagated not only by newly infiltrating inflammatory cells, but also by the accompaniment of immune cells normally present in non-inflamed ocular tissues.

Due to the different structures and tissue types in the eye, the immune responses to pathological or traumatic injury are distinct in different regions of the eye and excessive immune activity and cytokine release by immune cells can compromise visual acuity by inducing inflammation and fibrosis.

The aim of this Special Issue is to collect original research findings and reviews discussing the ocular immune system (including distribution, phenotype and function) in healthy eyes and in immune-related ocular diseases. We also welcome manuscripts discussing potential strategies for modulating immune responses in translational approaches.

Dr. Malihe Eskandarpour
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Research

17 pages, 2983 KiB  
Article
Soluble Collectin 11 (CL-11) Acts as an Immunosuppressive Molecule Potentially Used by Stem Cell-Derived Retinal Epithelial Cells to Modulate T Cell Response
by Giorgia Fanelli, Marco Romano, Giovanna Lombardi and Steven H. Sacks
Cells 2023, 12(13), 1805; https://doi.org/10.3390/cells12131805 - 7 Jul 2023
Cited by 1 | Viewed by 1296
Abstract
Retinal pigment epithelium (RPE) cell allotransplantation is seen as a possible solution to retinal diseases. However, the RPE-complement system triggered by the binding of collectin-11 (CL-11) is a potential barrier for RPE transplantation as the complement-mediated inflammatory response may promote T cell recognition. [...] Read more.
Retinal pigment epithelium (RPE) cell allotransplantation is seen as a possible solution to retinal diseases. However, the RPE-complement system triggered by the binding of collectin-11 (CL-11) is a potential barrier for RPE transplantation as the complement-mediated inflammatory response may promote T cell recognition. To address this, we investigated the role of CL-11 on T cell immuno-response. We confirmed that RPE cells up-regulated MHC class I and expressed MHC class II molecules in an inflammatory setting. Co-cultures of RPE cells with T cells led to the inhibition of T cell proliferation. We found that CL-11 was partially responsible for this effect as T cell binding of CL-11 inhibited T cell proliferation in association with the downregulation of CD28. We also found that the suppressive action of CL-11 was abrogated in the presence of the RGD peptide given to block the T cell binding of CL-11 by its collagen-like domain. Because RPE cells can bind and secrete CL-11 under stress conditions, we postulate that soluble CL-11 contributes to the immunosuppressive properties of RPE cells. The investigation of this dual biological activity of CL-11, namely as a trigger of the complement cascade and a modulator of T cell responses, may provide additional clues about the mechanisms that orchestrate the immunogenic properties of RPE cells. Full article
(This article belongs to the Special Issue The Role of Immune Cells in Ocular Diseases)
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