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Cells
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Cell Biology Research in Model Organism Drosophila
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Cell Biology Research in Model Organism Drosophila

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: closed (25 February 2024) | Viewed by 3652

Special Issue Editor

Dr. Maria Grazia Giansanti

E-Mail Website
Guest Editor
Istituto di Biologia e Patologia Molecolari del Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Biotecnologie, Università Sapienza di Roma, Piazzale Aldo Moro 5, 00185 Rome, Italy
Interests: Drosophila melanogaster; Drosophila model; oncoprotein; cytokinesis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cell biology, as a fundamental branch of science, unravels the intricacies of cellular structure, function, and organization, thereby shaping our understanding of life itself. The model organism Drosophila melanogaster, commonly known as the fruit fly, has emerged as a powerful and versatile tool for probing into the mysteries of cell biology. With its well-characterized genetics, short life cycle, and conserved cellular processes, Drosophila offers unique advantages to investigate cellular mechanisms with unparalleled precision and efficiency.

This Special Issue seeks to showcase the latest advancements and breakthroughs in cell biology research utilizing Drosophila as a model organism. Our aim is to bring together researchers and experts from diverse disciplines, fostering collaboration and knowledge exchange, ultimately pushing the boundaries of our comprehension of cellular processes.

This Special Issue encompasses a wide array of topics within cell biology research, all centered around the invaluable contributions of Drosophila as a model organism. Topics of interest include, but are not limited to, the following:

  1. Cellular Signaling Pathways: Investigating the intricate signaling cascades that regulate cellular processes, such as cell growth, differentiation, and apoptosis, in the context of Drosophila model systems.
  2. Cellular Morphogenesis: Exploring the dynamic changes in cell shape and structure during development, tissue regeneration, and organogenesis in Drosophila, shedding light on fundamental processes that shape multicellular organisms.
  3. Cell Division and Cell Cycle Regulation: Unraveling the mechanisms governing cell cycle progression, chromosome segregation, and the regulation of cell division fidelity in Drosophila cells.
  4. Cellular Trafficking and Transport: Investigating the intricate networks of intracellular transport and vesicle trafficking, elucidating the mechanisms of cargo delivery and compartmentalization in Drosophila cells.
  5. Cellular Homeostasis and Stress Responses: Understanding how Drosophila cells maintain homeostasis and respond to various environmental stresses, providing insights into cellular adaptability and survival.
  6. Cellular Interactions and Communication: Studying cell–cell interactions and communication, including cell adhesion, synaptic transmission, and immune responses, in the context of Drosophila model systems.

We invite researchers, academics, and scientists with a keen interest in cell biology and Drosophila research to contribute either orignial research articles or reviews to this Special Issue. Through this collaborative effort, we aim to foster a vibrant and stimulating scientific environment, driving innovative discoveries, and further cementing Drosophila as an indispensable model organism for cell biology research.

We look forward to your valuable contributions.

Dr. Maria Grazia Giansanti
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drosophila melanogaster
  • model organism
  • cell biology
  • developmental biology
  • genetics
  • molecular biology
  • cell signaling
  • cellular differentiation
  • cell proliferation
  • cell cycle
  • cellular morphogenesis
  • cell-cell communication
  • stem cells
  • organelle biology
  • mitosis
  • meiosis
  • cell migration
  • apoptosis
  • cytoskeleton
  • cell adhesion
  • membrane trafficking
  • intracellular transport
  • epigenetics
  • genome stability
  • cellular metabolism
  • immunity in drosophila
  • neurobiology
  • RNA biology
  • protein folding
  • functional genomics
  • CRISPR/Cas9 in drosophila
  • omics technologies
  • disease models
  • drug discovery
  • regeneration
  • genetic screens
  • cellular stress responses

Published Papers (3 papers)

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Research

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13 pages, 1767 KiB  
Article
Visualization of the Association of Dimeric Protein Complexes on Specific Enhancers in the Salivary Gland Nuclei of Drosophila Larva
by Solène Vanderperre and Samir Merabet
Cells 2024, 13(7), 613; https://0-doi-org.brum.beds.ac.uk/10.3390/cells13070613 - 01 Apr 2024
Viewed by 578
Abstract
Transcription factors (TFs) regulate gene expression by recognizing specific target enhancers in the genome. The DNA-binding and regulatory activity of TFs depend on the presence of additional protein partners, leading to the formation of versatile and dynamic multimeric protein complexes. Visualizing these protein–protein [...] Read more.
Transcription factors (TFs) regulate gene expression by recognizing specific target enhancers in the genome. The DNA-binding and regulatory activity of TFs depend on the presence of additional protein partners, leading to the formation of versatile and dynamic multimeric protein complexes. Visualizing these protein–protein interactions (PPIs) in the nucleus is key for decrypting the molecular cues underlying TF specificity in vivo. Over the last few years, Bimolecular Fluorescence Complementation (BiFC) has been developed in several model systems and applied in the analysis of different types of PPIs. In particular, BiFC has been applied when analyzing PPIs with hundreds of TFs in the nucleus of live Drosophila embryos. However, the visualization of PPIs at the level of specific target enhancers or genomic regions of interest awaits the advent of DNA-labelling methods that can be coupled with BiFC. Here, we present a novel experimental strategy that we have called BiFOR and that is based on the coupling of BiFC with the bacterial ANCHOR DNA-labelling system. We demonstrate that BiFOR enables the precise quantification of the enrichment of specific dimeric protein complexes on target enhancers in Drosophila salivary gland nuclei. Given its versatility and sensitivity, BiFOR could be applied more widely to other tissues during Drosophila development. Our work sets up the experimental basis for future applications of this strategy. Full article
(This article belongs to the Special Issue Cell Biology Research in Model Organism Drosophila)
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Review

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22 pages, 1311 KiB  
Review
Thermosensation and Temperature Preference: From Molecules to Neuronal Circuits in Drosophila
by Meng-Hsuan Chiang, Yu-Chun Lin, Tony Wu and Chia-Lin Wu
Cells 2023, 12(24), 2792; https://0-doi-org.brum.beds.ac.uk/10.3390/cells12242792 - 08 Dec 2023
Viewed by 1245
Abstract
Temperature has a significant effect on all physiological processes of animals. Suitable temperatures promote responsiveness, movement, metabolism, growth, and reproduction in animals, whereas extreme temperatures can cause injury or even death. Thus, thermosensation is important for survival in all animals. However, mechanisms regulating [...] Read more.
Temperature has a significant effect on all physiological processes of animals. Suitable temperatures promote responsiveness, movement, metabolism, growth, and reproduction in animals, whereas extreme temperatures can cause injury or even death. Thus, thermosensation is important for survival in all animals. However, mechanisms regulating thermosensation remain unexplored, mostly because of the complexity of mammalian neural circuits. The fruit fly Drosophila melanogaster achieves a desirable body temperature through ambient temperature fluctuations, sunlight exposure, and behavioral strategies. The availability of extensive genetic tools and resources for studying Drosophila have enabled scientists to unravel the mechanisms underlying their temperature preference. Over the past 20 years, Drosophila has become an ideal model for studying temperature-related genes and circuits. This review provides a comprehensive overview of our current understanding of thermosensation and temperature preference in Drosophila. It encompasses various aspects, such as the mechanisms by which flies sense temperature, the effects of internal and external factors on temperature preference, and the adaptive strategies employed by flies in extreme-temperature environments. Understanding the regulating mechanisms of thermosensation and temperature preference in Drosophila can provide fundamental insights into the underlying molecular and neural mechanisms that control body temperature and temperature-related behavioral changes in other animals. Full article
(This article belongs to the Special Issue Cell Biology Research in Model Organism Drosophila)
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15 pages, 1857 KiB  
Review
Using Drosophila melanogaster to Dissect the Roles of the mTOR Signaling Pathway in Cell Growth
by Anna Frappaolo and Maria Grazia Giansanti
Cells 2023, 12(22), 2622; https://0-doi-org.brum.beds.ac.uk/10.3390/cells12222622 - 14 Nov 2023
Cited by 2 | Viewed by 1424
Abstract
The evolutionarily conserved target of rapamycin (TOR) serine/threonine kinase controls eukaryotic cell growth, metabolism and survival by integrating signals from the nutritional status and growth factors. TOR is the catalytic subunit of two distinct functional multiprotein complexes termed mTORC1 (mechanistic target of rapamycin [...] Read more.
The evolutionarily conserved target of rapamycin (TOR) serine/threonine kinase controls eukaryotic cell growth, metabolism and survival by integrating signals from the nutritional status and growth factors. TOR is the catalytic subunit of two distinct functional multiprotein complexes termed mTORC1 (mechanistic target of rapamycin complex 1) and mTORC2, which phosphorylate a different set of substrates and display different physiological functions. Dysregulation of TOR signaling has been involved in the development and progression of several disease states including cancer and diabetes. Here, we highlight how genetic and biochemical studies in the model system Drosophila melanogaster have been crucial to identify the mTORC1 and mTORC2 signaling components and to dissect their function in cellular growth, in strict coordination with insulin signaling. In addition, we review new findings that involve Drosophila Golgi phosphoprotein 3 in regulating organ growth via Rheb-mediated activation of mTORC1 in line with an emerging role for the Golgi as a major hub for mTORC1 signaling. Full article
(This article belongs to the Special Issue Cell Biology Research in Model Organism Drosophila)
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