p38 MAPK Signaling in Physiology and Diseases
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".
Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 2011
Special Issue Editor
Interests: regulation of nuclear receptors in human cancer treatment
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
p38 Mitogen-activated protein kinases (p38MAPK) are a group of conserved protein kinases composed of four different genes: p38α, p38β, p38γ, and p38δ. While early studies showed that p38 MAPKs play an important role in inflammation and stress response, recent studies have shown that p38 family proteins are involved in many critical processes by a cell/tissues and isoform-specific mechanism. This Special Issue attempts to provide an update on recent developments in p38 MAPK signaling in inflammation, cardiovascular and metabolic disorders, neurodegeneration, and cancer.
Our Special issue aims to provide a broad description of the primary biological functions of P38 MAPKs in physiology and diseases; characterize p38MAPK signaling networks and crosstalk; explore the mechanisms underlying the role of p38MAPK signaling; and explore the therapeutic opportunities and discuss the challenges associated with the regulation of p38 MAPK activity. We hope that this Special Issue will contribute to the knowledge on the common and specific roles of p38 family proteins in physiology and pathology, and thereby develop novel therapeutics for the treatment of p38 MAPK-associated diseases.
Prof. Dr. Guan Chen
Guest Editor
Manuscript Submission Information
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Keywords
- p38 MAPKs
- inflammation
- metabolism
- neurodegeneration
- and cancer
