Chromatin Regulation in Brain Homeostasis and Disease
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Nuclei: Function, Transport and Receptors".
Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 2060
Special Issue Editor
2. Clinical and Biomedical Sciences, University of Exeter Medical School, Exeter, UK
Interests: chromatin; autism spectrum disorders; learning and memory
Special Issue Information
Dear Colleagues,
The structure and 3D organisation of chromatin within the nucleus are important determinants of cellular identity and function. The factors that regulate chromatin structure vary in their activity and include enzymes that covalently and reversibly modify DNA and histone proteins, directly remodel local chromatin structure by nucleosome translocation or eviction, pioneer transcription factors, factors that recruit and tether chromatin domains to specific subnuclear compartments, and large protein complexes that constrain 3D chromatin organisation in the nucleus. We are just beginning to understand the functions of some of these chromatin regulators in the development, maintenance and function of different brain regions, with their myriad of specialised cell types. Significant advances in human genetics over the last decade have led to the identification of mutations in the genes that encode chromatin regulators in brain diseases. No doubt, many more remain to be identified. These advances have left us with a wealth of disease associations, but little understanding of the molecular and cellular mechanisms that underlie these conditions. We invite contributions to this Special Issue from all areas related to this burgeoning field that provide novel insights into the importance of chromatin regulation in brain development and homeostasis and dysregulated mechanisms responsible for disease.
Prof. Albert Basson
Guest Editor
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