High Density Lipoproteins and Atherosclerosis
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 31218
Special Issue Editor
2. IRCCS Multimedica Hospital, 20099 Milan, Italy
Interests: atherosclerosis; dyslipidemias; cardiovascular disease; immunity; genetics; diabetes; lipoproteins; pharmacology; biochemistry; cardiology
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Epidemiological studies have shown an inverse correlation between high-density lipoprotein cholesterol (HDL-C) levels and the risk of cardiovascular disease, suggesting that increasing HDL-C levels would be beneficial. However, this assumption has been questioned by the failure of clinical trials testing HDL-C-raising therapies as well as the observations from Mendelian randomization studies showing that polymorphisms mainly or solely associated with increased HDL-C levels did not decrease the risk of myocardial infarction. These observations led to a shift in the focus from HDL-C levels toward HDL functional properties.
This Special Issue of Cells aims to discuss the relevance of HDL function in light of the most recent observations that suggest a higher risk of mortality and infection in subjects with extremely high HDL-C levels, and to deepen the knowledge of HDL’s role beyond its classical role in reverse cholesterol transport.
Prof. Alberico L. Catapano
Guest Editor
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Keywords
- HDL
- HDL-C
- HDL functionality
- atherosclerosis
- reverse cholesterol transport
- genetics