Understanding Cellular, Molecular, and Functional Specificity, Heterogeneity, and Diversity of the Endocannabinoid System

A special issue of Cells (ISSN 2073-4409).

Deadline for manuscript submissions: 20 December 2024 | Viewed by 263

Special Issue Editors

Center for Biosystems Dynamics Research, Laboratory for Cell Signaling Dynamics, RIKEN, Osaka University Graduate School of Frontier Biosciences, Osaka, Japan
Interests: large-scale single-cell omics; cluster analysis (UMAP, TSNE, PCA, etc.); imaging mass spectrometry; single-molecule visualization (JA); the endocannabinoid system; development; plasticity; epilepsy; neurotransmission; calcium signaling (MA)
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Guest Editor
Forefront Research Center, Osaka University Graduate School of Science, Osaka, Japan
Interests: large-scale single-cell omics; cluster analysis (UMAP, TSNE, PCA, etc.); imaging mass spectrometry; single-molecule visualization (JA); the endocannabinoid system; development; plasticity; epilepsy; neurotransmission; calcium signaling (MA)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The endocannabinoid system includes cannabinoid receptors, endocannabinoids (eCBs), and synthesizing and degrading enzymes. This is a widely recognized lipid messenger system involved in many aspects of our lives, including development, learning and memory, and diseases. Identifying the localization and diverse functions of eCBs and their cognate receptors has advanced our understanding of how this bioactive lipid system regulates our bodies and minds. This approach is fundamental to promoting further discoveries on each element of the eCB system within the context of cell and organ morphology under defined biological and medical conditions. In addition, integrating spot-targeted knowledge into an atlas-based or repository-type dataset using methods such as cluster analysis for dimensionality reduction may be desirable, as it can open up new vistas for discovering underexplored molecules and functions in the eCB system in both health and diseases. 

In this Special Issue, we welcome reports on original findings regarding the structure and function of the eCB system, as well as methodologies for data processing with dimensionality reduction and data visualization. We hope that a collection of excellent papers in this Special Issue will advance our understanding of the cellular and molecular specificity, heterogeneity, and diversity of each element of the eCB system in a wide range of organisms, spanning from cell lines to vertebrates, including humans. We also offer an enjoyable forum to develop new ideas in data mining and interpretation with fuller perspectives.

Dr. Jun Aoki
Dr. Masako Isokawa
Guest Editors

Manuscript Submission Information

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Keywords

  • molecular markers
  • brain circuits
  • development
  • neural plasticity
  • neurological disorders
  • immune diseases
  • cancer
  • cluster analysis

Published Papers (1 paper)

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Editorial

3 pages, 296 KiB  
Editorial
Understanding Cellular, Molecular, and Functional Specificity, Heterogeneity, and Diversity of the Endocannabinoid System
by Jun Aoki and Masako Isokawa
Cells 2024, 13(12), 1049; https://0-doi-org.brum.beds.ac.uk/10.3390/cells13121049 - 17 Jun 2024
Viewed by 186
Abstract
The endocannabinoid system (ECS) is a widely recognized lipid messenger system involved in many aspects of our health and diseases [...] Full article
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