Hypoxia and Cancer: Mechanisms of Resistance and Metastasis
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: closed (15 January 2022) | Viewed by 43824
Special Issue Editor
Special Issue Information
Dear Colleagues,
Hypoxia, or inadequate oxygenation of a solid tumor, leads to tumor progression. Tumor hypoxia also negatively affects therapeutic outcomes in part by inducing genetic changes in neoplastic cells that promote cancer cell survival. Hypoxia-inducible factors (HIFs) and their target gene products are highly active in cancer and have been shown to contribute to chemotherapeutic resistance. Consequently, alleviating hypoxia in solid tumors is considered a promising target for improving the efficacy of anti-cancer therapeutics. The precise contribution of hypoxia in altering the cellular composition, non-cellular composition and cell phenotypes is emerging and will be important to consider when developing novel therapies for cancer patients.
This current volume aims to present new ideas and novel findings on how hypoxia influences
- the immune landscape in cancer;
- the cancer stem cell phenotype;
- metastasis;
- resistance to therapy;
- invasion of epithelial cells into the connective tissue;
- the epithelial-to-mesenchymal transition; and
- new tools that can provide a quantitative insight into the O2 levels in human tumors, experimental tumors and organoids.
Dr. Daniele M. Gilkes
Guest Editor
Manuscript Submission Information
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Keywords
- hypoxia
- hypoxia-inducible factors
- metastasis
- cancer
- immune evasion