Dear Colleagues,

A major challenge in neuroscience is to understand the cellular and molecular mechanisms underlying brain function and diseases. The brain is one of the most complex organs composed of different cell types. Inhibitory and excitatory neurons form intricate circuits underlying complex behaviors. Importantly, a well-balanced neuronal excitation and inhibition is crucial for proper brain function, while alterations in this balance are associated with a number of neurological and neuropsychiatric disorders, such as epilepsy and schizophrenia. This Special Issue will focus on γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system. GABA is very powerful in controlling neuronal excitability and information processing; however, several knowledge gaps remain regarding the role of GABAergic neurons, the regulation of GABA release and GABA receptors, GABA neuro- and glio-transmission, and synaptic plasticity.

This Special Issue aims to highlight new findings regarding the role GABA in the nervous system. A better understanding of GABA function may not only provide new insights into brain health, but it is also crucial for the development of more effective therapeutic approaches for several neuropathological conditions, involving dysregulations in the GABA system.

Dr. Kaoutsar Nasrallah
Prof. Dr. Dominique Debanne
Guest Editors

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