Adipose Tissue Dysfunction and the Therapeutic Role of Exercise
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Metabolism".
Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 4754
Special Issue Editor
Special Issue Information
Dear Colleagues,
Adipose tissue is a central metabolic organ in the regulation of whole-body energy homeostasis. Dysregulation in any one of the three primary functions of adipocytes (lipid storage, endocrine/paracrine function, and insulin responsiveness) can have major impacts on overall metabolic health. Moreover, adipose tissue dysfunction is a predictor of metabolic diseases and cardiovascular events, thus highlighting the relevance of research concerning the therapeutic strategies for the maintenance of "healthy adipose tissue".
Physical inactivity is a direct cause of the inflammation and metabolic dysfunction associated with obesity. Emerging evidence indicates that regular exercise could be the most important non-pharmacological strategy for the prevention and treatment of obesity and its related cardiovascular/metabolic diseases. The beneficial effects on the overall metabolic health (including improvements in glucose tolerance, insulin sensitivity, and the lowering of circulating lipid concentrations) have historically been attributed to adaptations in skeletal muscle. However, in recent years, there has been growing consensus for assigning exercise a therapeutic role to combat adipose tissue-derived metabolic dysfunction, even in the absence of weight loss.
In adipose tissue, exercise training reduces lipid content and inflammation, regulates browning and thermogenesis, and modulates the production of adipokines. However, the mechanisms by which exercise causes such adipose remodelling and whether or not the actions of exercise contribute to the systemic improvement of insulin sensitivity and metabolic health remain undefined.
Authors are encouraged to send their contributions, in the form of original manuscripts or reviews, that analyse the factors that trigger exercise-induced adipose adaptations and the underlying molecular mechanisms.
The aim of this Special Issue is to increase knowledge on the following:
- the molecular and cellular biology and pathophysiology of adipose dysfunction.
- the role of adipose tissue as a metabolically active, "exercise-responsive" organ, as well as elucidating a methodology for advanced exercise effectiveness.
- exercise interventions that will specifically target adipose tissue metabolic health.
- molecular signatures of exercise-induced adipose adaptations to achieve health-promoting therapies.
Dr. Rita De Matteis
Guest Editor
Manuscript Submission Information
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Keywords
- physical activity
- exercise prescription
- white adipose tissue
- brown adipose tissue
- browning
- metabolic disease
- hypertrophic adipocyte
- oxidative stress
- inflammation
- immunometabolism
- endoplasmic reticulum
- adipokines
- batokines
