Hyaluronic Acid in Tissue Inflammation and Regeneration

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Proliferation and Division".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 5844

Special Issue Editors


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Guest Editor
Department of Pharmacy, University “G. d’Annunzio” Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy
Interests: mesenchymal stem cell differentiation; biomaterials; tissue regeneration; hyaluronic acid; histology
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Guest Editor
Department of Pharmacy, University “G. d’Annunzio” Chieti-Pescara, Via dei Vestini 31, 66100 Chieti, Italy
Interests: inflammation; hyaluronic acid; biomaterials; oxidative stress; tendons
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Hyaluronic acid (HA) is a large glycosaminoglycan that regulates physiological processes in most tissues. HA is a biocompatible, biodegradable, and hydrophilic macromolecule. The discovery of the HA composite’s biological roles has led to the promotion of new investigations and clinical interest in several fields, such as medicine, ophthalmology, articular pathologies, cutaneous repair, skin remodeling, vascular prosthesis, tissue engineering, and nerve reconstruction. It has been widely reported that HA and HA receptors are involved in a wide range of physiological and pathological functions and are key mediators during inflammation, healing processes, and tissue regeneration. Finally, the use of HA-based biomaterials in drug delivery systems has recently increased due to the great targeting capability of this polysaccharide on its receptor complex on cell membranes.

This Special Issue aims to present a collection of research achievements regarding hyaluronic acid and its use for regenerative medicine and pharmaceutical purposes.

Prof. Amelia Cataldi
Dr. Marialucia Gallorini
Guest Editors

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Keywords

  • hyaluronic acid
  • inflammation
  • tissue regeneration

Published Papers (1 paper)

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Review

13 pages, 1358 KiB  
Review
The Impact of Hyaluronic Acid on Tendon Physiology and Its Clinical Application in Tendinopathies
by Francesco Oliva, Emanuela Marsilio, Giovanni Asparago, Antonio Frizziero, Anna Concetta Berardi and Nicola Maffulli
Cells 2021, 10(11), 3081; https://0-doi-org.brum.beds.ac.uk/10.3390/cells10113081 - 09 Nov 2021
Cited by 26 | Viewed by 5021
Abstract
The physical–chemical, structural, hydrodynamic, and biological properties of hyaluronic acid within tendons are still poorly investigated. Medical history and clinical applications of hyaluronic acid for tendinopathies are still debated. In general, the properties of hyaluronic acid depend on several factors including molecular weight. [...] Read more.
The physical–chemical, structural, hydrodynamic, and biological properties of hyaluronic acid within tendons are still poorly investigated. Medical history and clinical applications of hyaluronic acid for tendinopathies are still debated. In general, the properties of hyaluronic acid depend on several factors including molecular weight. Several preclinical and clinical experiences show a good efficacy and safety profile of hyaluronic acid, despite the absence of consensus in the literature regarding the classification according to molecular weight. In in vitro and preclinical studies, hyaluronic acid has shown physical–chemical properties, such as biocompatibility, mucoadhesivity, hygroscopicity, and viscoelasticity, useful to contribute to tendon healing. Additionally, in clinical studies, hyaluronic acid has been used with promising results in different tendinopathies. In this narrative review, findings encourage the clinical application of HA in tendinopathies such as rotator cuff, epicondylitis, Achilles, and patellar tendinopathy. Full article
(This article belongs to the Special Issue Hyaluronic Acid in Tissue Inflammation and Regeneration)
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