Dear Colleagues,

We are in the midst of establishing a Special Issue on the hot topic “Cytochrome P450” for the journal CIMB. Cytochrome P450 (CYP) is a superfamily of enzymes that function as monooxygenases and contain heme as a cofactor. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.

CYP enzymes have been identified in all kingdoms of life: animals, plants, fungi, protists, bacteria, archaea, and even in viruses. More than 50,000 distinct CYP proteins are known. CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. There are 57 CYP isoforms in humans, and their role in human drug metabolism, including chemotherapeutic drugs, is well known. However, their role in the metabolism of endogenous substrates is not completely understood. Hence, there is a need for further research to elucidate the mechanisms of CYP regulation and the molecular role of CYP in the metabolism of drugs, nutrients, xenobiotics, and endogenous compounds.

Original manuscripts and reviews dealing with the regulation and role of CYP enzymes in metabolism of xenobiotics or endobiotics are invited for consideration, for publication in CIMB.

Prof. Dr. Bhagavatula Moorthy
Dr. Romi Ghose
Guest Editors

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