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Special Issue "Cytochrome P450 (CYP)"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Biology".

Deadline for manuscript submissions: closed (30 September 2021).

Special Issue Editors

Prof. Dr. Bhagavatula Moorthy
Guest Editor
Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
Interests: cytochrome P450; Ah receptor; hyperoxic lung injury; ARDS; bronchopulmonary dysplasia; polycyclic aromatic hydrocarbons; carcinogenesis; oxidative stress
Special Issues, Collections and Topics in MDPI journals
Dr. Romi Ghose
Guest Editor
Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Health Building 2, Room 7045, 4849 Calhoun Rd., Houston, TX 77204-5037, USA
Interests: regulation of drug metabolizing enzymes during inflammation; obesity and diseases; gastrointestinal toxicity of chemotherapy drugs; pharmacokinetic/pharmacodynamic studies

Special Issue Information

Dear Colleagues,

We are in the midst of establishing a Special Issue on the hot topic “Cytochrome P450” for the journal IJMS. Cytochrome P450 (CYP) is a superfamily of enzymes that function as monooxygenases and contain heme as a cofactor. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.

CYP enzymes have been identified in all kingdoms of life: animals, plants, fungi, protists, bacteria, archaea, and even in viruses. More than 50,000 distinct CYP proteins are known. CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. There are 57 CYP isoforms in humans, and their role in human drug metabolism, including chemotherapeutic drugs, is well known. However, their role in the metabolism of endogenous substrates is not completely understood. Hence, there is a need for further research to elucidate the mechanisms of CYP regulation and the molecular role of CYP in the metabolism of drugs, nutrients, xenobiotics, and endogenous compounds.

Original manuscripts and reviews dealing with the regulation and role of CYP enzymes in metabolism of xenobiotics or endobiotics are invited for consideration, for publication in IJMS.

Prof. Dr. Bhagavatula Moorthy
Dr. Romi Ghose
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (1 paper)

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Genome-Wide Identification of CYP72A Gene Family and Expression Patterns Related to Jasmonic Acid Treatment and Steroidal Saponin Accumulation in Dioscorea zingiberensis
Int. J. Mol. Sci. 2021, 22(20), 10953; https://0-doi-org.brum.beds.ac.uk/10.3390/ijms222010953 - 11 Oct 2021
Viewed by 247
Dioscorea zingiberensis is a medicinal herb containing a large amount of steroidal saponins, which are the major bioactive compounds and the primary storage form of diosgenin. The CYP72A gene family, belonging to cytochromes P450, exerts indispensable effects on the biosynthesis of numerous bioactive [...] Read more.
Dioscorea zingiberensis is a medicinal herb containing a large amount of steroidal saponins, which are the major bioactive compounds and the primary storage form of diosgenin. The CYP72A gene family, belonging to cytochromes P450, exerts indispensable effects on the biosynthesis of numerous bioactive compounds. In this work, a total of 25 CYP72A genes were identified in D. zingiberensis and categorized into two groups according to the homology of protein sequences. The characteristics of their phylogenetic relationship, intron–exon organization, conserved motifs and cis-regulatory elements were performed by bioinformatics methods. The transcriptome data demonstrated that expression patterns of DzCYP72As varied by tissues. Moreover, qRT-PCR results displayed diverse expression profiles of DzCYP72As under different concentrations of jasmonic acid (JA). Likewise, eight metabolites in the biosynthesis pathway of steroidal saponins (four phytosterols, diosgenin, parvifloside, protodeltonin and dioscin) exhibited different contents under different concentrations of JA, and the content of total steroidal saponin was largest at the dose of 100 μmol/L of JA. The redundant analysis showed that 12 DzCYP72As had a strong correlation with specialized metabolites. Those genes were negatively correlated with stigmasterol and cholesterol but positively correlated with six other specialized metabolites. Among all DzCYP72As evaluated, DzCYP72A6, DzCYP72A16 and DzCYP72A17 contributed the most to the variation of specialized metabolites in the biosynthesis pathway of steroidal saponins. This study provides valuable information for further research on the biological functions related to steroidal saponin biosynthesis. Full article
(This article belongs to the Special Issue Cytochrome P450 (CYP))
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