Special Issue "Cytochrome P450 (CYP)"
Deadline for manuscript submissions: closed (30 September 2021).
Interests: cytochrome P450; Ah receptor; hyperoxic lung injury; ARDS; bronchopulmonary dysplasia; polycyclic aromatic hydrocarbons; carcinogenesis; oxidative stress
Special Issues, Collections and Topics in MDPI journals
Interests: regulation of drug metabolizing enzymes during inflammation; obesity and diseases; gastrointestinal toxicity of chemotherapy drugs; pharmacokinetic/pharmacodynamic studies
We are in the midst of establishing a Special Issue on the hot topic “Cytochrome P450” for the journal IJMS. Cytochrome P450 (CYP) is a superfamily of enzymes that function as monooxygenases and contain heme as a cofactor. In mammals, these proteins oxidize steroids, fatty acids, and xenobiotics, and are important for the clearance of various compounds as well as for hormone synthesis and breakdown. In plants, these proteins are important for the biosynthesis of defensive compounds, fatty acids, and hormones.
CYP enzymes have been identified in all kingdoms of life: animals, plants, fungi, protists, bacteria, archaea, and even in viruses. More than 50,000 distinct CYP proteins are known. CYPs are, in general, the terminal oxidase enzymes in electron transfer chains, broadly categorized as P450-containing systems. There are 57 CYP isoforms in humans, and their role in human drug metabolism, including chemotherapeutic drugs, is well known. However, their role in the metabolism of endogenous substrates is not completely understood. Hence, there is a need for further research to elucidate the mechanisms of CYP regulation and the molecular role of CYP in the metabolism of drugs, nutrients, xenobiotics, and endogenous compounds.
Original manuscripts and reviews dealing with the regulation and role of CYP enzymes in metabolism of xenobiotics or endobiotics are invited for consideration, for publication in IJMS.
Prof. Dr. Bhagavatula Moorthy
Dr. Romi Ghose
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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