Conferences
28 October 2021, Online
Cells Webinar | Cellular and Molecular Mechanisms Underlying the Pathogenesis of Hepatic Fibrosis
The hallmark of hepatic fibrosis is the formation and deposition of excess fibrous connective tissue, which destroys the physiological architecture of the liver. This process is highly dynamic and involves cross-talk between parenchymal cells (hepatocytes), non-parenchymal cells (Kupffer cells, hepatic stellate cells, sinusoidal endothelial cells), and infiltrating immune cells. Left untreated, advanced liver fibrosis may progress to severe forms of the disease, such as liver cirrhosis, liver failure and hepatocellular carcinoma.
In the past, significant progress in many aspects of hepatic fibrosis research has been made. In particular, central mediators (cytokines, chemokines, lipotoxic substances) have been identified that play critical roles in orchestrating the process of fibrogenesis and influx of immune cells to sites of tissue injury. The translation of these findings to novel therapies is currently ongoing. However, effective treatments are still missing and key questions in the pathogenesis of hepatic fibrosis and its consequences are unanswered.
In this Webinar, eminent experts from Germany, Spain and France discuss novel basic and clinical aspects of hepatic fibrogenesis and potential molecular targets for therapeutic intervention.
The following experts will be present and talk:
- Prof. Dr. Ralf Weiskirchen, Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry (IFMPEGKC), RWTH University Hospital Aachen, Germany
- Prof. Dr. Claus Hellerbrand, Institute of Biochemistry, Friedrich-Alexander University, Erlangen-Nürnberg, Germany
- Prof. Dr. Matías A. Ávila, Hepatology Program, Center for Applied Medical Research (CIMA), University of Navarra, Spain
- Prof. Dr. Thomas F. Baumert, Institut National de la Santé et de la Recherche Médicale, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques (IVH), France
When? 28 October 2021 at 2:00 pm CEST | 8:00am EDT | 8:00pm CST Asia
Click here to register now!
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