Calcium Signalling in Cancer
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (20 December 2020) | Viewed by 10336
Special Issue Editor
Interests: calcium signaling; cancer, store-operated calcium entry; breast cancer; brain cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The calcium ion (Ca2+) is an intracellular second messenger involved in diverse cellular processes, including gene transcription, cell growth and death, differentiation, metabolism, muscle contraction, and neuronal plasticity. Intracellular Ca2+ signals are specific in magnitude, time course and location, and are controlled by various components of the calcium signaling toolkit including Ca2+ channels, pumps, exchangers, and regulators. In addition to its various physiological roles, Ca2+ signaling is also involved in pathological conditions including cancer. Indeed, Ca2+ is implicated in a variety of cancer-related processes including proliferation, angiogenesis, invasion, and metastasis. While the Ca2+ signal is ubiquitous, the proteins that control Ca2+ transport are highly specialized. The expression and/or activity of these proteins is frequently dysregulated in different types of cancers where they promote specific oncogenic processes. Understanding the role of these proteins in cancer provides critical information about cancer biology and may pave the way for the development of novel therapeutic approaches.
This Special Issue of Genes aims to present novel insights into the diverse roles of Ca2+ signaling and Ca2+ signal regulators in various types of cancer, as well as potential therapeutic and diagnostic opportunities this may provide. Contributions by experts in the field in the form of research papers and critical reviews are invited.
Dr. Iman Azimi
Guest Editor
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Keywords
- Calcium signaling
- Cancer
- Calcium channels and pumps
- Targeted therapy
- Biomarkers