Dear Colleagues,

Through the remarkable advancement in human genetics in recent decades, multiple loci that affect the risk of developing T1D have been discovered. For most of the T1D-associated loci, however, the causal candidate genes and variants linked to disease risk remain undefined. To obtain a better understanding of the molecular basis of T1D genetics, it is important to identify the specific disease-promoting genes and variants in the risk loci and to functionally evaluate them in relevant biological model systems.

In this Special Issue, we welcome reviews, new methods, and original articles covering many aspects of functional T1D candidate gene studies. These include, but are not limited to, computational studies to pinpoint causal candidate genes, expressional regulation of T1D loci-associated genes in relevant tissues (such as immune cells and pancreatic islets/b-cells), the impact of candidate genes on immune cell function, the impact of candidate genes on b-cell function and apoptosis (e.g. loss- and gain-of-function studies), and functional studies of candidate genes in animal models (such as knockout mice). We look forward to your contributions.

Dr. Joachim Størling
Prof. Flemming Pociot
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• Type 1 diabetes (T1D) 
• Genetics 
• Candidate gene 
• Single nucleotide polymophism (SNP) 
• Genome-wide association study (GWAS) 
• β-cells 
• Pancreatic islets 
• Immune cells 
• Apoptosis