Special Issue "Genetic and Epigenetic Regulation of Placental Development and Disease"
Deadline for manuscript submissions: 15 January 2022.
Precise regulation of placental gene expression at each stage of pregnancy is crucial for the successful establishment and maintenance of pregnancy. Dysregulation of these gene regulatory mechanisms during pregnancy has been implicated in most pregnancy complications, including preeclampsia, preterm birth, intrauterine growth restriction, abruptio placentae, and late spontaneous abortion, which have enormous impacts on the life-long health of mothers and the babies born to mothers with these conditions. However, the molecular underpinnings of placental developmental defects leading to such pregnancy complications are still poorly understood. By understanding the molecular pathways and the distinct defects in trophoblast development and differentiation associated with each pregnancy disease, we could develop much needed diagnostic, preventive, and therapeutic strategies for these diseases.
The goal of this Special Issue is to publish high-quality manuscripts with special emphasis on the genetic and epigenetic regulation of normal placental development and placental developmental defects leading to different pregnancy complications. We welcome reviews, new methods, short communications, and original articles covering all aspects of trophoblast development and differentiation and pregnancy diseases using culture models, clinical studies, and animal models. Priorities for publication will be given to studies related to the impact of DNA methylation, histone post-translational modifications, non-coding RNA (long non-coding RNA and microRNA), and epigenetic biomarkers for pregnancy diseases.
We look forward to your contributions.Prof. Dr. Nihar R Nayak
Prof. Dr. Gary Sutkin
Prof. Dr. Sunil Jaiman
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Trophoblast invasion
- Trophoblast differentiation
- Maternal–fetal interaction
- Spiral artery remodeling
- Vascular complications in pregnancy
- Pregnancy diseases
- Gene regulation
- Epigenetic regulation
- Biomarkers for pregnancy diseases
- Placental development