Special Issue "Transcription Regulation in Aging"

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 25 October 2021.

Special Issue Editor

Dr. Sebastian Iben
E-Mail Website
Guest Editor
Department of Dermatology and Allergology, Ulm University Hospital, 89081 Ulm, Germany
Interests: aging; RNA polymerase I; rDNA; rRNA processing; ribosome; translational fidelity; loss of proteostasis; Cockayne syndrome; trichothiodystrophy

Special Issue Information

Dear Colleagues,

Aging is the inevitable process of functional decline after a period of maturity. It is accompanied by a decrease in functionality of cells, tissues, organs, and organisms. This functional decline is characterized by signaling pathways, the “hallmarks of aging” that include amongst others genomic instability, telomere attrition, senescence, loss of proteostasis, and epigenetic alterations that are directly or indirectly affecting the process of gene expression. Gene expression patterns specify and mirror cellular conditions as an effort to sustain homeostasis and functionality. The initial step of gene expression is transcription of DNA by the RNA polymerases and is, as all processes in the cell, affected by aging. Thus transcription itself is subject to functional decline and decreasing strength of regulation. Transcriptomic data allow researchers to characterize the changes in gene expression patterns that occur during aging and display typical changes. In this issue, we would like to sum up the current knowledge of how aging processes affect the regulation of transcription by the RNA polymerases and thus impact on gene expression and cellular homeostasis.

Dr. Sebastian Iben
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • RNA polymerase I,II,III
  • Aging
  • Transcription
  • Transcription elongation
  • Transcription factors
  • lncRNA
  • Gene expression
  • Transcription/splicing
  • miRNA
  • Aging-associated disease

Published Papers

This special issue is now open for submission.
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