Special Issue "Transcription Regulation in Aging"
Deadline for manuscript submissions: 25 October 2021.
Aging is the inevitable process of functional decline after a period of maturity. It is accompanied by a decrease in functionality of cells, tissues, organs, and organisms. This functional decline is characterized by signaling pathways, the “hallmarks of aging” that include amongst others genomic instability, telomere attrition, senescence, loss of proteostasis, and epigenetic alterations that are directly or indirectly affecting the process of gene expression. Gene expression patterns specify and mirror cellular conditions as an effort to sustain homeostasis and functionality. The initial step of gene expression is transcription of DNA by the RNA polymerases and is, as all processes in the cell, affected by aging. Thus transcription itself is subject to functional decline and decreasing strength of regulation. Transcriptomic data allow researchers to characterize the changes in gene expression patterns that occur during aging and display typical changes. In this issue, we would like to sum up the current knowledge of how aging processes affect the regulation of transcription by the RNA polymerases and thus impact on gene expression and cellular homeostasis.
Dr. Sebastian Iben
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- RNA polymerase I,II,III
- Transcription elongation
- Transcription factors
- Gene expression
- Aging-associated disease