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Bacterial Zoonoses
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Bacterial Zoonoses

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Environmental Microbiology".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 3681

Special Issue Editor

Prof. Dr. Zongfu Wu

E-Mail Website
Guest Editor
College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210014, China
Interests: Streptococcus suis; Streptococcus pasteurianus; bacterial pathogenesis; bacterial RNA regulation; bacterial molecular epidemiology; antibiotic resistance; vaccines
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Zoonoses present a significant threat to public health worldwide. Bacterial zoonoses can be transmitted to humans through close contact with infected animals such as livestock, pets, fish, and wildlife. Many aspects such as global climate changes, closer interactions with animals, and antimicrobials overuse contribute to emerging or re-emerging bacterial zoonoses. These continuously developing factors increase the importance and spread of bacterial zoonoses. For this Special Issue, original research articles and reviews addressing topics of epidemiology, molecular biology, vaccine development research, pathogenesis, immune responses, antimicrobial resistance, and treatment of bacterial zoonoses are welcome, especially those combining a high academic standard coupled with a practical focus on controlling bacterial zoonoses.

Prof. Dr. Zongfu Wu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bacterial zoonoses
  • epidemiology
  • bacterial pathogenesis
  • antimicrobial resistance
  • vaccine development
  • immune responses

Published Papers (2 papers)

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Research

11 pages, 3092 KiB  
Article
Inhibitory Effect of Monoterpenoid Glycosides Extracts from Peony Seed Meal on Streptococcus suis LuxS/AI-2 Quorum Sensing System and Biofilm
by Jinpeng Li, Yamin Shen, Jing Zuo, Shuji Gao, Haikun Wang, Yuxin Wang, Li Yi, Xiaogai Hou and Yang Wang
Int. J. Environ. Res. Public Health 2022, 19(23), 16024; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph192316024 - 30 Nov 2022
Cited by 3 | Viewed by 1515
Abstract
Streptococcus suis LuxS/AI-2 quorum sensing system regulates biofilm formation, resulting in increased pathogenicity and drug resistance, and diminished efficacy of antibiotic treatment. The remaining peony seed cake after oil extraction is rich in monoterpenoid glycosides, which can inhibit the formation of bacterial biofilm. [...] Read more.
Streptococcus suis LuxS/AI-2 quorum sensing system regulates biofilm formation, resulting in increased pathogenicity and drug resistance, and diminished efficacy of antibiotic treatment. The remaining peony seed cake after oil extraction is rich in monoterpenoid glycosides, which can inhibit the formation of bacterial biofilm. In this study, we investigated the effect of seven major monocomponents (suffruticosol A, suffruticosol B, suffruticosol C, paeonifloin, albiflorin, trans-ε-viniferin, gnetin H) of peony seed meal on minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of S. suis. The results showed that the MICs of the seven single components were all greater than 200 μg/mL, with no significant bacteriostatic and bactericidal advantages. Crystal violet staining and scanning electron microscope observation showed that the seven single components had a certain inhibitory effect on the biofilm formation ability of S. suis at sub-MIC concentration. Among them, the ability of paeoniflorin to inhibit biofilm was significantly higher than that of the other six single components. AI-2 signaling molecules were detected by bioreporter strain Vibrio harvey BB170. The detection results of AI-2 signal molecules found that at 1/2 MIC concentration, paeoniflorin significantly inhibited the production of S. suis AI-2 signal, and the inhibitory effect was better than that of the other six single components. In addition, molecular docking analysis revealed that paeoniflorin had a significant binding activity with LuxS protein compared with the other six single components. The present study provides evidence that paeoniflorin plays a key role in the regulation of the inhibition of S. suis LuxS/AI-2 system and biofilm formation in peony seed meal. Full article
(This article belongs to the Special Issue Bacterial Zoonoses)
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12 pages, 4272 KiB  
Article
Sub-Inhibitory Concentrations of Amoxicillin and Tylosin Affect the Biofilm Formation and Virulence of Streptococcus suis
by Jing Zuo, Qingying Fan, Jinpeng Li, Baobao Liu, Bingqian Xue, Xiaoling Zhang, Li Yi and Yang Wang
Int. J. Environ. Res. Public Health 2022, 19(14), 8359; https://0-doi-org.brum.beds.ac.uk/10.3390/ijerph19148359 - 8 Jul 2022
Cited by 3 | Viewed by 1692
Abstract
Streptococcus suis (S. suis) can form a protective biofilm during infection and lead to prolonged disease. Oral antibiotics are often used for treatment in clinical practice, but sub-inhibitory concentration levels often exist due to low oral absorption rate, resulting in disease [...] Read more.
Streptococcus suis (S. suis) can form a protective biofilm during infection and lead to prolonged disease. Oral antibiotics are often used for treatment in clinical practice, but sub-inhibitory concentration levels often exist due to low oral absorption rate, resulting in disease deterioration. The purpose of this study was to investigate the effects of Amoxicillin and Tylosin on the biofilm formation and virulence of S. suis HA9801 at sub-inhibitory concentration. We first determined that the test groups (1/4MIC Amoxicillin and Tylosin) could significantly increase the amount of biofilm formation without affecting bacterial growth. The LD50 value of the test groups was significantly higher than that of the control group in the mouse infection model. In the mouse infection model, the LD50 value of the experimental group was significantly increased, but the tissue bacterial load was significantly decreased. Further RT-PCR analysis showed that the expression levels of virulence-related genes in the experimental group were significantly reduced. Our study suggests that both Amoxicillin and Tylosin at sub-inhibitory concentrations could enhance the biofilm formation ability of S. suis HA9801 and reduce its virulence to form persistent infection. Full article
(This article belongs to the Special Issue Bacterial Zoonoses)
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