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International Journal of Molecular Sciences publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic. The journal’s Editor-in-Chief and/or designated EBM will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Ferroptosis: Emerging Mechanisms, Physiological Functions, and Therapeutic Applications
edited by
submission deadline 30 Aug 2024 | Viewed by 69 | Submission Open
Keywords: ferroptosis; biomarker; iron metabolism; diseases; precision medicine
(This special issue belongs to the Section Biochemistry)
TRP Channel, 2nd Edition
edited by
submission deadline 30 Aug 2024 | Viewed by 69 | Submission Open
Keywords: TRP; TRPAnkyrin; TRPCanonical; TRPMelastatin; TRPPolycystin; TRPVanilloid
(This special issue belongs to the Section Molecular Pharmacology)
Heart Failure: From Molecular Basis to Therapeutic Strategies
edited by
submission deadline 30 Aug 2024 | Viewed by 68 | Submission Open
Keywords: heart failure; cardiac metabolism; mitochondria; inflammatory pathway; neurohormonal system; therapeutical strategies
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Advances in Neuroprotective Strategies for Ocular Diseases
edited by
submission deadline 30 Aug 2024 | Viewed by 67 | Submission Open
Keywords: neuroprotection; neurodegeneration; neuronal cell death; regeneration; pyroptosis; inflammation; optic nerve injuries; translational research; photoreceptors; retinal ganglion cells; inflammasomes; microglia; complement pathways
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Research of Hydroxyapatite-Based Materials and Their Applications
edited by
submission deadline 30 Aug 2024 | Viewed by 66 | Submission Open
Keywords: hydroxyapatite; nanobiocomposite; biomedical applications; coatings; environment remediation; biological properties; drug delivery; pollutant adsorption efficiency; morphology and structural features
(This special issue belongs to the Section Materials Science)
Plant Resistance and Tolerance to Salt–Alkaline Stress: Current Status and Future Directions
edited by
submission deadline 30 Aug 2024 | Viewed by 64 | Submission Open
Keywords: salt– alkaline stress; abiotic stress; molecular genetics; multi-omics analysis; plant breeding; climate change; agricultural sustainability
(This special issue belongs to the Section Molecular Plant Sciences)
Biological Application of Natural Products Antioxidant Activity
edited by Adriana C. E. Graziano and Rosanna Avola
submission deadline 30 Aug 2024 | Viewed by 63 | Submission Open
Keywords: natural products; natural product chemistry; plant extract; polyphenols; antioxidant activity; nutraceuticals; mechanism of action; phytochemicals
(This special issue belongs to the Section Bioactives and Nutraceuticals)
New Insights into the Pathogenesis of Type 1 Diabetes submission deadline 30 Aug 2024 | Viewed by 61 | Submission Open
Keywords: type 1 diabetes; insulin-dependent diabetes mellitus; human leukocyte antigen (HLA); pathogenesis
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Fluorescence Techniques for Exploring Protein Oligomerization
edited by
submission deadline 30 Aug 2024 | Viewed by 60 | Submission Open
Keywords: protein oligomerization; Fö rster Resonance Energy Transfer (FRET); quantifying protein interactions; single molecule fluorescence; super-resolution microscopy; fluorescence fluctuation spectroscopy
(This special issue belongs to the Section Biochemistry)
Anxiolytic or Antidepressant Activity Components in Medicinal Plants
edited by Carolina López-Rubalcava
submission deadline 30 Aug 2024 | Viewed by 60 | Submission Open
Keywords: phytopharmacology; anxiety; depression; medicinal plants; animal models
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Molecular Computational Methods for Studying the Effects of Radiation on Human Beings submission deadline 30 Aug 2024 | Viewed by 60 | Submission Open
Keywords: DNA damage; biophysical models; DNA geometrical models; computational radiobiology; Monte Carlo simulations; ionizing radiation; heavy ions; DNA damage repair
(This special issue belongs to the Section Molecular Biophysics)
Viral Infections and Immune Responses submission deadline 30 Aug 2024 | Viewed by 59 | Submission Open
Keywords: virus; infections; immune response; T-cells; B-cells; antibodies; neutralizing activity
(This special issue belongs to the Section Molecular Immunology)
New Molecular Advances in Legionella Research
edited by Carolina Hurtado-Marcos
submission deadline 30 Aug 2024 | Viewed by 58 | Submission Open
Keywords: Legionella species; Legionella-associated diseases; new Diagnosis of Legionella; immune evasió n by Legionella; legionella and interaction amebas; virulence factors of Legionella
(This special issue belongs to the Section Molecular Microbiology)
The Medicinal Mechanism of Natural Products in Cancer Therapies
edited by
submission deadline 30 Aug 2024 | Viewed by 57 | Submission Open
Keywords: natural product; phytochemicals; protein– ligand interaction; mechanism of action; drug discovery; prevention; treatment
(This special issue belongs to the Section Bioactives and Nutraceuticals)
Alzheimer’s Disease: Molecular Mechanisms and Pharmacological Approaches submission deadline 30 Aug 2024 | Viewed by 56 | Submission Open
Keywords: Alzheimer’ s disease; drug discovery; G protein-coupled receptors; molecular mechanisms; neuroinflammation; target validation; therapeutic effects
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Photodynamic Therapy for Cancer Treatment
edited by
submission deadline 30 Aug 2024 | Viewed by 53 | Submission Open
Keywords: cancer; photodynamic theapy; photosensitizer; cell death; technological advances
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Challenges and Advances of Therapeutic Approaches in Human Diseases: Focus on Stem Cell Therapies
edited by
submission deadline 30 Aug 2024 | Viewed by 50 | Submission Open
Keywords: stem cells therapies; embryonic stem cells; mesenchymal stromal cells; hematopoietic stem cells; induced pluripotent stem cells; human disorders
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Crosstalk between Metabolism and Neuroprotection submission deadline 30 Aug 2024 | Viewed by 44 | Submission Open
Keywords: neurology; neuroprotective actions of leptin; neuroprotective actions; leptin; deep-brain photoreception; neurodegeneration
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
Molecular Advances in Skin Diseases 3.0
edited by
submission deadline 30 Aug 2024 | Viewed by 40 | Submission Open
Keywords: infection; inflammation; molecular; neoplasm; pathogenesis; skin diseases
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Peroxisome and Lysosome in Health and Disease
edited by
submission deadline 30 Aug 2024 | Viewed by 37 | Submission Open
Keywords: peroxisomes; lysosomes; autophagy; lysosomal diseases; peroxidase; oxidative stress; acid hydrolase; lysosomal storage disease(LSD); gaucher disease
(This special issue belongs to the Section Molecular Biology)
Molecular Mechanisms of Gastrointestinal Immune System and Its Role in Gut Homeostasis and Pathologies submission deadline 31 Aug 2024 | 5 articles | Viewed by 17333 | Submission Open
Keywords: gastrointestinal immune system; inflammation; intestinal infections; host– microbe interactions; pattern recognition receptors; gut microbiota; gut dysbiosis; IgA; inflammatory bowel disease; inflammatory bowel syndrome; coeliac disease; colorectal cancer; food allergy
(This special issue belongs to the Section Molecular Immunology)
Biofilm Antimicrobial Strategies: Outlook and Future Perspectives
edited by
submission deadline 31 Aug 2024 | 8 articles | Viewed by 13869 | Submission Open
Keywords: biofilm formation; biofilm development; biofilm control; surfaces; adhesion; drug resistance; new antimicrobial agents; antibiofilm agents
(This special issue belongs to the Section Molecular Microbiology)
Mitochondrial Metabolism Alterations in Health and Disease submission deadline 31 Aug 2024 | 4 articles | Viewed by 13534 | Submission Open
(This special issue belongs to the Section Biochemistry)
Advances in Mass Spectrometry-Based Proteomics submission deadline 31 Aug 2024 | 6 articles | Viewed by 13032 | Submission Open
Keywords: proteomics; mass spectrometry; clinical research; bioinformatics; structural biology; biomarkers; orbitrap; time-of-flight; ion mobility; chromatography; peptides; proteins
(This special issue belongs to the Section Molecular Biology)
Rational Design and Application of Functional Hydrogels
edited by and
submission deadline 31 Aug 2024 | 5 articles | Viewed by 12034 | Submission Open
Keywords: hydrogel network; mechanical property; material engineering; biomedical engineering; soft actuator; biosensing; tissue engineering
(This special issue belongs to the Section Materials Science)
Molecular Biomarkers in Cancer and Chronic Inflammation: New Therapeutic Approaches submission deadline 31 Aug 2024 | 4 articles | Viewed by 10681 | Submission Open
Keywords: cancer; inflammation; cell signaling; gene expression; protein expression; tumor escape mechanisms
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advanced Biochemical Research: Transcription in Cancer Initiation and Progression submission deadline 31 Aug 2024 | 3 articles | Viewed by 9412 | Submission Open
Keywords: cancer; transcription; transcription factors and co-factors; chromatin remodeling; epigenetic modification; oncogenes; suppressors; cell cycle; E2F-dependent gene transcription; tumor resistance; signaling
(This special issue belongs to the Section Biochemistry)
Advances in Osteogenesis
edited by
submission deadline 31 Aug 2024 | 7 articles | Viewed by 8666 | Submission Open
Keywords: osteogenesis; osteoblast; bone formation; disease; bone
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Nanoparticles in Nanobiotechnology and Nanomedicine
edited by
submission deadline 31 Aug 2024 | 6 articles | Viewed by 7824 | Submission Open
Keywords: nanoparticles; properties of nanoparticles; methods of  obtaining nanoparticles; characterization techniques; theoretical models; computational simulation; applications in nanomedicine; applications in nanobiotechnology
(This special issue belongs to the Section Molecular Nanoscience)
Blast-Induced Neurotrauma: Molecular Mechanisms Supported by Comparative Experimental and Clinical Findings
edited by
submission deadline 31 Aug 2024 | 6 articles | Viewed by 7777 | Submission Open
Keywords: blast injuries; blast-induced neurotrauma; experimental research; experimental models; clinical research; molecular mechanisms; biomarkers; imaging; neurological deficits; treatment
(This special issue belongs to the Section Molecular Neurobiology)
Functional Role of Cytokines in Cancer and Chronic Inflammation submission deadline 31 Aug 2024 | 6 articles | Viewed by 6762 | Submission Open
Keywords: cytokines; interleukins; cytokine antagonists; signaling pathways; chronic inflammation; immunometabolism; cancer development; cancer progression; immunotherapy; cytokine therapy
(This special issue belongs to the Section Biochemistry)
Updates in Cell and Molecular Mechanisms of Autoimmune Diseases 2.0
edited by
submission deadline 31 Aug 2024 | 3 articles | Viewed by 6520 | Submission Open
Keywords: adjuvant effect; autoimmune; cell kinetics; epigenetic; genetic regulation; interdisciplinary approach; kawasaki disease; molecular mechanisms; post-infectious (e.g.; COVID-19) autoimmunity; rheumatoid arthritis; systemic lupus erythematosus; theranostics of extracellular vesicles; thrombosis; thyroid disease; type 1 diabetes; vaccine-mediated autoimmunity
(This special issue belongs to the Section Molecular Immunology)
Adipose Tissue Diseases: Physiopathology, Molecular Mechanism, Diagnosis and Treatment
edited by , Sandro Michelini and
submission deadline 31 Aug 2024 | 3 articles | Viewed by 6350 | Submission Open
Keywords: lipedema; inflammation; body fat; adipose tissue; Dercum disease; lipomatosis; lipodystrophy; adipocyte
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Mitochondrial Genome of Aquatic Animals: Analysis of Structure, Evolution and Diversity submission deadline 31 Aug 2024 | 5 articles | Viewed by 6102 | Submission Open
Keywords: aquatic animals; genomics; mitogenomes; structure; phylogenetic informativeness; evolution; comparative genomics; diversity; biomarker; function; mitonuclear relations
(This special issue belongs to the Section Molecular Genetics and Genomics)
Recent Advances in Biopolymer Composites submission deadline 31 Aug 2024 | 5 articles | Viewed by 5838 | Submission Open
Keywords: biopolymers; composites; biodegradability; nanoparticles; mechanical properties; biomedical applications; antibacterial activity
(This special issue belongs to the Section Materials Science)
Antitumor and Anti-infective Agents from Marine Organisms submission deadline 31 Aug 2024 | 2 articles | Viewed by 5694 | Submission Open
Keywords: marine organisms; antitumor compounds; bioactive molecules; marine biotechnology; drug discovery; cancer treatment; mechanism of action
(This special issue belongs to the Section Molecular Oncology)
Exploring the Glioblastoma Complexity: New Perspectives in the Molecular and Imaging Fields submission deadline 31 Aug 2024 | 5 articles | Viewed by 5275 | Submission Open
Keywords: glioblastoma; imaging techniques; molecular techniques; liquid biopsy; in vitro model; in vivo model
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Advances in Protein Dynamics
edited by and
submission deadline 31 Aug 2024 | 4 articles | Viewed by 5260 | Submission Open
Keywords: protein structure; protein structure modelling; protein structural dynamics; time-resolved methods; protein– protein interactions; structure-based drug design; structural background of protein function; structural background of protein stability; folded and disordered proteins
(This special issue belongs to the Section Molecular Biophysics)
Genomics in Neurodegenerative Diseases
edited by
submission deadline 31 Aug 2024 | 2 articles | Viewed by 5249 | Submission Open
Keywords: neurodegenerative disorders; redox systems; proteostasis; seeding misfolded proteins; antimicrobial peptides; epigenome
(This special issue belongs to the Section Molecular Genetics and Genomics)
Viral and Host Targets to Fight RNA Viruses
edited by
submission deadline 31 Aug 2024 | 3 articles | Viewed by 5207 | Submission Open
Keywords: RNA viruses; antiviral agents; medicinal chemistry; direct-acting antivirals; host-targeting agents; drug design
(This special issue belongs to the Section Molecular Genetics and Genomics)
Fabrication Strategies of Molecular Layers for Modern Medical Applications submission deadline 31 Aug 2024 | 4 articles | Viewed by 5205 | Submission Open
Keywords: molecular layers; engineered proteins; nanotechnology; medical applications
(This special issue belongs to the Section Materials Science)
Advances in Coagulation and Anticoagulation
edited by
submission deadline 31 Aug 2024 | 4 articles | Viewed by 5082 | Submission Open
Keywords: coagulation; anticoagulation; procoagulant; anticoagulant; molecular mechanism
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Regulatory Mechanism and Network of Abiotic Stress-Response in Plants 2.0
edited by
submission deadline 31 Aug 2024 | 5 articles | Viewed by 4833 | Submission Open
Keywords: abiotic stress response; osmotic stress; temperature stress; transcriptional regulation; post-transcriptional regulation; regulatory mechanism; gene regulatory network
(This special issue belongs to the Section Molecular Plant Sciences)
Targeting Oxidative Stress for Disease submission deadline 31 Aug 2024 | 5 articles | Viewed by 4743 | Submission Open
Keywords: oxidants and free radical production; physiological activities of free radicals; detrimental effects of free radicals on human health; ROS and ROS-mediated cellular signaling; pathophysiology of oxidative stress; biomarkers of oxidative stress; chronic degenerative diseases; therapeutic approaches targeting oxidative stress; biochemical/molecular targets of chronic diseases; exogenous antioxidants and human health; flavonoids and redox biology in the pathophysiology of diseases; pro-oxidative role of antioxidants: double-sided sword; prooxidant agents in therapy
(This special issue belongs to the Section Molecular Biology)
Molecular and Pathophysiological Mechanisms of Peritoneal Fibrosis in Peritoneal Dialysis
edited by Kimio Watanabe
submission deadline 31 Aug 2024 | 3 articles | Viewed by 4680 | Submission Open
Keywords: peritoneal fibrosis; peritoneal dialysis; TGF-β /smad signaling; bioincompatible dialysis solution; peritoneal inflammation; mesothelial-to-mesenchymal transition
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Novel Biopolymeric Materials Incorporating Bioactive Ingredients and Their Applications submission deadline 31 Aug 2024 | 3 articles | Viewed by 4548 | Submission Open
Keywords: biopolymers; encapsulated bioactive agents; antioxidants; antimicrobials; extended release
(This special issue belongs to the Section Materials Science)
Molecular Research of Microbial Infection and Phage Therapy
edited by
submission deadline 31 Aug 2024 | 2 articles | Viewed by 4531 | Submission Open
Keywords: phage therapy; antimicrobial resistance; microbiome; infection; inflammation; bacteriophage; virome
(This special issue belongs to the Section Molecular Pathology, Diagnostics, and Therapeutics)
Molecular Metabolisms and Regulations of Algae
edited by
submission deadline 31 Aug 2024 | 4 articles | Viewed by 4529 | Submission Open
Keywords: algal enzymes; metabolic pathways; information-processing proteins; signal molecules and transducers; central metabolism; secondary metabolism; anaerobic metabolism; fermentation; omics technologies; biofuel production; protein post-translational modifications
(This special issue belongs to the Section Molecular Plant Sciences)
Recent Developments in Molecular and Cellular Cardiology: Mathematical Models, Cell Model, and Organoids
edited by Andrea Barbuti and
submission deadline 31 Aug 2024 | 4 articles | Viewed by 4275 | Submission Open
Keywords: arrhythmias; cardiovascular diseases; ion channels; stem-cell derived cardiomyocytes; cardiac cellular models; cardiomyopathies; organoids; mathematical models
(This special issue belongs to the Section Molecular Biology)
Mitochondrial Dysfunctions and Metabolisms
edited by
submission deadline 31 Aug 2024 | 5 articles | Viewed by 4226 | Submission Open
Keywords: mitochondrial diseases; OXPHOS deficiency; electron transfer chain defects; biosynthesis of redox cofactors; oxidative stress; mitochondrial biogenesis; mitochondrial shape and dynamics; mitochondrial iron metabolism; translation into the clinic; drug strategies
(This special issue belongs to the Section Molecular Endocrinology and Metabolism)
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