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Molecular Imaging of Biomaterials
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Molecular Imaging of Biomaterials

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: closed (31 May 2019) | Viewed by 6248

Special Issue Editor

Dr. Bhavesh D. Kevadiya

E-Mail Website
Guest Editor
Department of Radiology, School of Medicine, Stanford University, Palo Alto, CA 94304, USA
Interests: nanocomposites; drug delivery; nanocompoistes for biomedical applications; cell therapy and bioscaffold development
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue is designed for an overview of bioimaging technology that is currently in use in diagnostic and therapeutic applications. This issue includes original and cutting-edge research and mini-review articles that reflect fields of design and therapeutic applications of nanomaterials for targeting based on imaging, nanomedicine, molecular imaging, nuclear medicine, designing of unique probes for biosensing, drug biodistribution, drug–polymer conjugations as imaging agents, aggregation-induced emission, and personalized medicine. Bioimaging technology is highly useful for the noninvasive and real-time measurement of drug biodistributions, diagnosis, and efficacy treatments, monitoring the progression of disease drug development and finding physiological pathways in vivo at the cellular and molecular levels. Biomaterials can be but are not limited to QDs, magnetic nanoparticles, carbon-based materials, labeling of drugs, dye, polymers, peptides, antibodies, and macromolecules. Designs of bioimaging materials with drugs, imaging agents, or nucleic acids are incorporated into single nanoparticles to build a multifunctional probe, which permits theranostics. This Special Issue will provide an overview of current research on the synthesis, characterization, and design of nanomaterials and their applications for bioimaging technology.

Dr. Bhavesh D. Kevadiya
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bioimaging
  • theranostics
  • nanoparticles
  • nanomedicine
  • molecular imaging technology
  • radiochemistry
  • MRI
  • SPECT/CT
  • PET
  • IVIS
  • drug biodistribution

Published Papers (1 paper)

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Research

15 pages, 5292 KiB  
Article
Gadolinium-Labelled Cell Scaffolds to Follow-up Cell Transplantation by Magnetic Resonance Imaging
by Valeria Catanzaro, Giuseppe Digilio, Federico Capuana, Sergio Padovan, Juan C. Cutrin, Fabio Carniato, Stefano Porta, Cristina Grange, Nenad Filipović and Magdalena Stevanović
J. Funct. Biomater. 2019, 10(3), 28; https://0-doi-org.brum.beds.ac.uk/10.3390/jfb10030028 - 02 Jul 2019
Cited by 6 | Viewed by 5984
Abstract
Cell scaffolds are often used in cell transplantation as they provide a solid structural support to implanted cells and can be bioengineered to mimic the native extracellular matrix. Gadolinium fluoride nanoparticles (Gd-NPs) as a contrast agent for Magnetic Resonance Imaging (MRI) were incorporated [...] Read more.
Cell scaffolds are often used in cell transplantation as they provide a solid structural support to implanted cells and can be bioengineered to mimic the native extracellular matrix. Gadolinium fluoride nanoparticles (Gd-NPs) as a contrast agent for Magnetic Resonance Imaging (MRI) were incorporated into poly(lactide-co-glycolide)/chitosan scaffolds to obtain Imaging Labelled Cell Scaffolds (ILCSs), having the shape of hollow spherical/ellipsoidal particles (200–600 μm diameter and 50–80 μm shell thickness). While Gd-NPs incorporated into microparticles do not provide any contrast enhancement in T1-weighted (T1w) MR images, ILCSs can release Gd-NPs in a controlled manner, thus activating MRI contrast. ILCSs seeded with human mesenchymal stromal cells (hMSCs) were xenografted subcutaneously into either immunocompromised and immunocompetent mice without any immunosuppressant treatments, and the transplants were followed-up in vivo by MRI for 18 days. Immunocompromised mice showed a progressive activation of MRI contrast within the implants due to the release of Gd-NPs in the extracellular matrix. Instead, immunocompetent mice showed poor activation of MRI contrast due to the encapsulation of ILCSs within fibrotic capsules and to the scavenging of released Gd-NPs by phagocytic cells. In conclusion, the MRI follow-up of cell xenografts can report the host cell response to the xenograft. However, it does not strictly report on the viability of transplanted hMSCs. Full article
(This article belongs to the Special Issue Molecular Imaging of Biomaterials)
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