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Advanced Nanosciences in Regenerative Medicine and Cancer Treatment
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Advanced Nanosciences in Regenerative Medicine and Cancer Treatment

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Drug Delivery".

Deadline for manuscript submissions: closed (31 August 2023) | Viewed by 6998

Special Issue Editors

Dr. Sorina Dinescu

E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Biology, University of Bucharest, 91-95 Spl. Independentei, 050095 Bucharest, Romania
Interests: stem cells; biomaterials; regenerative medicine; exosomes; miRNAs; molecular biology; regenerative therapies
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Marieta Costache

E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Biology, University of Bucharest, 91-95 Spl. Independentei, 050095 Bucharest, Romania
Interests: tissue engineering; regenerative medicine; biomaterials; drug delivery; stem cells; stem cell differentiation; molecular biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, the use of nanoscience was introduced in the biomedical field for regenerative medicine and, moreover, cancer treatment. Nanotechnologies developed over the years brought forward nanomaterials, nanoparticles, nanosensors, and nanocarriers designed with enhanced properties in order to provide improved treatments. In the context of designing implants used for tissue regeneration, nanospecies within nanomaterials contribute to stimulating cell proliferation and better cellular adhesion to the substrate. Nanoparticles with different origins, such as magnetic, polymeric, metallic, silica, quantum dots, etc., can be used either functionalized as part of nanomaterials in order to modulate the interaction with cells, or to deliver drugs or other substances to specific types of cells (i.e., cancer cells). Moreover, nanotechnology offers numerous methods to specifically target cancerous cells and enhance the therapeutic effects of other treatments. Other nanomaterials, such as carbon nanotubes, polymeric micelles, liposomes, etc., have been successfully used in cancer drug design. Cumulatively, all these nanosystems can be used to develop personalized treatments used in the fields of regenerative medicine or cancer therapy.

This Special Issue addresses "Advanced Nanosciences in Regenerative Medicine and Cancer Treatment", with a special focus on nanosystems as drug delivery platforms and nanomaterials used in regenerative medicine and cancer treatment. This Special Issue in The Journal of Functional Biomaterials aims to publish original articles, short communications, and reviews from scientists working in advanced nanosciences, with applications for the research and biomedical fields, including, but not limited to:

  • Nanomaterials designed for tissue engineering and regenerative medicine research applications;
  • Nanomaterials used in cancer drug design;
  • Nanocarriers used to deliver drugs/natural compounds that favor tissue regeneration, and/or wound healing;
  • Nanocarriers used to deliver drugs or other substances to cancer cells;
  • Nanoparticles that have applicability in either regenerative medicine or cancer drug delivery;
  • Advanced drug delivery systems for cancer treatment;
  • Nanotechnologies used in the biomedical field.

We very much look forward to your valuable contributions.

Dr. Sorina Dinescu
Prof. Dr. Marieta Costache
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanoscience
  • nanotechnology
  • nanomaterials
  • nanoparticles
  • nanospecies
  • nanocarriers
  • nanocomposites
  • tissue engineering
  • regenerative medicine
  • cancer treatment

Published Papers (3 papers)

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Research

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14 pages, 3764 KiB  
Article
Improved Bone Regeneration Using Biodegradable Polybutylene Succinate Artificial Scaffold in a Rabbit Model
by Giulio Edoardo Vigni, Giovanni Cassata, Giusj Caldarella, Roberta Cirincione, Mariano Licciardi, Giovanni Carlo Miceli, Roberto Puleio, Lorenzo D’Itri, Roberta Lo Coco, Lawrence Camarda and Luca Cicero
J. Funct. Biomater. 2023, 14(1), 22; https://0-doi-org.brum.beds.ac.uk/10.3390/jfb14010022 - 30 Dec 2022
Cited by 2 | Viewed by 1487
Abstract
The treatment of extensive bone loss represents a great challenge for orthopaedic and reconstructive surgery. Most of the time, those treatments consist of multiple-stage surgeries over a prolonged period, pose significant infectious risks and carry the possibility of rejection. In this study, we [...] Read more.
The treatment of extensive bone loss represents a great challenge for orthopaedic and reconstructive surgery. Most of the time, those treatments consist of multiple-stage surgeries over a prolonged period, pose significant infectious risks and carry the possibility of rejection. In this study, we investigated if the use of a polybutylene succinate (PBS) micro-fibrillar scaffold may improve bone regeneration in these procedures. In an in vivo rabbit model, the healing of two calvarial bone defects was studied. One defect was left to heal spontaneously while the other was treated with a PBS scaffold. Computed tomography (CT) scans, histological and immunohistochemical analyses were performed at 4, 12 and 24 weeks. CT examination showed a significantly larger area of mineralised tissue in the treated defect. Histological examination confirmed a greater presence of active osteoblasts and mineralised tissue in the scaffold-treated defect, with no evidence of inflammatory infiltrates around it. Immunohistochemical analysis was positive for CD56 at the transition point between healthy bone and the fracture zone. This study demonstrates that the use of a PBS microfibrillar scaffold in critical bone defects on a rabbit model is a potentially effective technique to improve bone regeneration. Full article
(This article belongs to the Special Issue Advanced Nanosciences in Regenerative Medicine and Cancer Treatment)
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Review

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26 pages, 3037 KiB  
Review
Targeted EGFR Nanotherapy in Non-Small Cell Lung Cancer
by Andreea Crintea, Anne-Marie Constantin, Alexandru C. Motofelea, Carmen-Bianca Crivii, Maria A. Velescu, Răzvan L. Coșeriu, Tamás Ilyés, Alexandra M. Crăciun and Ciprian N. Silaghi
J. Funct. Biomater. 2023, 14(9), 466; https://0-doi-org.brum.beds.ac.uk/10.3390/jfb14090466 - 09 Sep 2023
Cited by 1 | Viewed by 2104
Abstract
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide. Despite advances in treatment, the prognosis remains poor, highlighting the need for novel therapeutic strategies. The present review explores the potential of targeted epidermal growth factor receptor (EGFR) nanotherapy as [...] Read more.
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide. Despite advances in treatment, the prognosis remains poor, highlighting the need for novel therapeutic strategies. The present review explores the potential of targeted epidermal growth factor receptor (EGFR) nanotherapy as an alternative treatment for NSCLC, showing that EGFR-targeted nanoparticles are efficiently taken up by NSCLC cells, leading to a significant reduction in tumor growth in mouse models. Consequently, we suggest that targeted EGFR nanotherapy could be an innovative treatment strategy for NSCLC; however, further studies are needed to optimize the nanoparticles and evaluate their safety and efficacy in clinical settings and human trials. Full article
(This article belongs to the Special Issue Advanced Nanosciences in Regenerative Medicine and Cancer Treatment)
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19 pages, 2561 KiB  
Review
Magnetic Nanomaterials Mediate Electromagnetic Stimulations of Nerves for Applications in Stem Cell and Cancer Treatments
by Lei Wang, Yefan Duan, Shujie Lu and Jianfei Sun
J. Funct. Biomater. 2023, 14(2), 58; https://0-doi-org.brum.beds.ac.uk/10.3390/jfb14020058 - 20 Jan 2023
Cited by 2 | Viewed by 2339
Abstract
Although some progress has been made in the treatment of cancer, challenges remain. In recent years, advancements in nanotechnology and stem cell therapy have provided new approaches for use in regenerative medicine and cancer treatment. Among them, magnetic nanomaterials have attracted widespread attention [...] Read more.
Although some progress has been made in the treatment of cancer, challenges remain. In recent years, advancements in nanotechnology and stem cell therapy have provided new approaches for use in regenerative medicine and cancer treatment. Among them, magnetic nanomaterials have attracted widespread attention in the field of regenerative medicine and cancer; this is because they have high levels of safety and low levels of invasibility, promote stem cell differentiation, and affect biological nerve signals. In contrast to pure magnetic stimulation, magnetic nanomaterials can act as amplifiers of an applied electromagnetic field in vivo, and by generating different effects (thermal, electrical, magnetic, mechanical, etc.), the corresponding ion channels are activated, thus enabling the modulation of neuronal activity with higher levels of precision and local modulation. In this review, first, we focused on the relationship between biological nerve signals and stem cell differentiation, and tumor development. In addition, the effects of magnetic nanomaterials on biological neural signals and the tumor environment were discussed. Finally, we introduced the application of magnetic-nanomaterial-mediated electromagnetic stimulation in regenerative medicine and its potential in the field of cancer therapy. Full article
(This article belongs to the Special Issue Advanced Nanosciences in Regenerative Medicine and Cancer Treatment)
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