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Responsive Materials for Drug Delivery and Tissue Engineering
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Responsive Materials for Drug Delivery and Tissue Engineering

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Biomaterials".

Deadline for manuscript submissions: closed (31 January 2021) | Viewed by 2932

Special Issue Editors

Prof. Dr. John Hardy

E-Mail Website
Guest Editor
Chemistry and Materials Science Institute, Lancaster University, Lancaster, UK
Interests: supramolecular chemistry; polymers; stimuli-responsive materials; biomaterials; drug delivery; tissue engineering
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Baolin Guo

E-Mail Website
Co-Guest Editor
Institute of Frontier Science and Technology, Xi’an Jiaotong University, Xi'an 710049, China
Interests: hydrogel; wound healing; hemostat; tissue engineering; conducting biomaterials

Special Issue Information

Dear Colleagues,

Stimuli-responsive materials have emerged as an exciting area of materials science and engineering. It is an inherently interdisciplinary research area that uses chemistry and chemical engineering to design, synthesize, and characterise materials of various classes (e.g. ceramics, glasses, metals, polymers, etc.). These stimuli-responsive materials have exhibited increasingly important applications in various fileds, including drug delivery, tissue engineering, diagnostics, biosensors, microelectromechanical systems, coatings, etc. In this Special Issue of Materials devoted to "Responsive Materials for Drug Delivery and Tissue Engineering", we warmly invite submissions related to the design principles underpinning such materials, their computational and theoretical modelling, their synthesis and engineering, and their applications.

Dr. John George Hardy & Dr. Baolin Guo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Materials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stimuli-responsive materials
  • biomaterials
  • biomedical engineering
  • pharmaceutical sciences
  • drug delivery
  • tissue engineering

Published Papers (1 paper)

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Research

18 pages, 2938 KiB  
Article
Poly(N-vinylcaprolactam) and Salicylic Acid Polymeric Prodrug Grafted onto Medical Silicone to Obtain a Novel Thermo- and pH-Responsive Drug Delivery System for Potential Medical Devices
by José M. Cornejo-Bravo, Kenia Palomino, Giovanni Palomino-Vizcaino, Oscar M. Pérez-Landeros, Mario Curiel-Alvarez, Benjamín Valdez-Salas, Emilio Bucio and Héctor Magaña
Materials 2021, 14(5), 1065; https://0-doi-org.brum.beds.ac.uk/10.3390/ma14051065 - 25 Feb 2021
Cited by 13 | Viewed by 2134
Abstract
New medical devices with anti-inflammatory properties are critical to prevent inflammatory processes and infections in medical/surgical procedures. In this work, we present a novel functionalization of silicone for medical use with a polymeric prodrug and a thermosensitive polymer, by graft polymerization (gamma rays), [...] Read more.
New medical devices with anti-inflammatory properties are critical to prevent inflammatory processes and infections in medical/surgical procedures. In this work, we present a novel functionalization of silicone for medical use with a polymeric prodrug and a thermosensitive polymer, by graft polymerization (gamma rays), for the localized release of salicylic acid, an analgesic, and anti-inflammatory drug. Silicone rubber (SR) films were functionalized in two stages using graft polymerization from ionizing radiation (60Co). The first stage was grafting poly(N-vinylcaprolactam) (PNVCL), a thermo-sensitive polymer, onto SR to obtain SR-g-PNVCL. In the second stage, poly(2-methacryloyloxy-benzoic acid) (P2MBA), a polymeric prodrug, was grafted to obtain (SR-g-PNVCL)-g-P2MBA. The degree of functionalization depended on the concentrations of monomers and the irradiation dose. The films were characterized by attenuated total reflectance Fourier-transform infrared spectroscopy (ATR-FTIR), scanning electron microscopy/energy-dispersive X-ray spectrometry (SEM–EDX), thermogravimetric analysis (TGA), and contact angle. An upper critical solution temperature (UCST) of the films was demonstrated by the swelling degree as a temperature function. (SR-g-PNVCL)-g-P2MBA films demonstrated hydrolysis-mediated drug release from the polymeric prodrug, pH, and temperature sensitivity. GC–MS confirmed the presence of the drug (salicylic acid), after polymer hydrolysis. The concentration of the drug in the release media was quantified by HPLC. Cytocompatibility and thermo-/pH sensitivity of functionalized medical silicone were demonstrated in cancer and non-cancer cells. Full article
(This article belongs to the Special Issue Responsive Materials for Drug Delivery and Tissue Engineering)
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