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Biotechnological Approaches and Biomaterials for Enhanced Wound Healing

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A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Biomaterials for Tissue Engineering and Regenerative Medicine".

Deadline for manuscript submissions: closed (31 July 2021) | Viewed by 22427

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Special Issue Editors

Dr. John G. Hardy

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Guest Editor

1. Department of Chemistry, Faraday Building, Lancaster University, Lancaster LA1 4YB, UK
2. Materials Science Institute, Faraday Building, Lancaster University, Lancaster LA1 4YB, UK
Interests: polymer synthesis; supramolecular materials; biomaterials; stimuli-responsive materials; drug delivery; tissue engineering; sustainability
Special Issues, Collections and Topics in MDPI journals

Prof. Dr. Bing Hu

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Guest Editor

Oral Biology & Associate Head of School (Research), Peninsula Dental School, Faculty of Health, University of Plymouth, Plymouth, UK
Interests: skin and oral cancer; regeneration; 3D printing; tooth; tissue engineering; wound healing; diseases

Special Issue Information

Dear Colleagues,

There are various wound types encountered on humans and animals on a daily basis (e.g., abrasions, acute wounds, burn wounds, contusions, lacerations, surgical wounds/incision, and traumatic wounds). The healing process can be delayed by a number of factors, both local (related to the wound itself) and systemic (related to the patient and their clinical condition), which has potential for significant cost for the healthcare system and society. Despite the clinical need for improved wound healing outcomes, there is little innovation in wound healing technologies on the market.

This Special Issue is devoted to state-of-the-art biotechnological approaches and biomaterials for wound healing. Such biotechnological approaches include materials and methods that enhance wound healing (including therapeutic, diagnostic, and clinical procedures) in organs and tissues.

We warmly welcome the submission of manuscripts on the topic of the “Biotechnological Approaches and Biomaterials For Enhanced Wound Healing” Special Issue.

Dr. John G. Hardy
Prof. Dr. Bing Hu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

antimicrobial
bioactivity
boengineering
bioethics
biomaterials
biophysical approaches
biosensors
biotechnology
chemosensors
clinical
drug delivery
imaging
regenerative medicine
scar tissue
stem cells

Published Papers (2 papers)

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Research

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19 pages, 2215 KiB

Open AccessArticle

Physically Crosslinked Chitosan/PVA Hydrogels Containing Honey and Allantoin with Long-Term Biocompatibility for Skin Wound Repair: An In Vitro and In Vivo Study

by Mojtaba Koosha, Hadis Aalipour, Mohammad Javad Sarraf Shirazi, Ali Jebali, Hong Chi, Sepideh Hamedi, Nianxing Wang, Tianduo Li and Hamideh Moravvej

J. Funct. Biomater. 2021, 12(4), 61; https://0-doi-org.brum.beds.ac.uk/10.3390/jfb12040061 - 11 Nov 2021

Cited by 23 | Viewed by 4398

Abstract

Chitosan/PVA hydrogel films crosslinked by the freeze–thaw method and containing honey and allantoin were prepared for application as wound dressing materials. The effects of the freeze–thaw process and the addition of honey and allantoin on the swelling, the gel content and the mechanical properties of the samples were evaluated. The physicochemical properties of the samples, with and without the freeze–thaw process, were compared using FTIR, DSC and XRD. The results showed that the freeze–thaw process can increase the crystallinity and thermal stability of chitosan/PVA films. The freeze–thaw process increased the gel content but did not have a significant effect on the tensile strength. The presence of honey reduced the swelling and the tensile strength of the hydrogels due to hydrogen bonding interactions with PVA and chitosan chains. Long-term cell culture experiments using normal human dermal fibroblast (NHDF) cells showed that the hydrogels maintained their biocompatibility, and the cells showed extended morphology on the surface of the hydrogels for more than 30 days. The presence of honey significantly increased the biocompatibility of the hydrogels. The release of allantoin from the hydrogel was studied and, according to the Korsmeyer–Peppas and Weibull models, the mechanism was mainly diffusional. The results for the antimicrobial activity against E. coli and S. aureus bacteria showed that the allantoin-containing samples had a more remarkable antibacterial activity against S. aureus. According to the wound healing experiments, 98% of the wound area treated by the chitosan/PVA/honey hydrogel was closed, compared to 89% for the control. The results of this study suggest that the freeze–thaw process is a non-toxic crosslinking method for the preparation of chitosan/PVA hydrogels with long term biocompatibility that can be applied for wound healing and skin tissue engineering. Full article

(This article belongs to the Special Issue Biotechnological Approaches and Biomaterials for Enhanced Wound Healing)

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Review

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17 pages, 1626 KiB

Open AccessFeature PaperEditor’s ChoiceReview

Electrical Stimulation to Enhance Wound Healing

by Saranya B. Rajendran, Kirsty Challen, Karen L. Wright and John G. Hardy

J. Funct. Biomater. 2021, 12(2), 40; https://0-doi-org.brum.beds.ac.uk/10.3390/jfb12020040 - 19 Jun 2021

Cited by 34 | Viewed by 17171

Abstract

Electrical stimulation (ES) can serve as a therapeutic modality accelerating the healing of wounds, particularly chronic wounds which have impaired healing due to complications from underlying pathology. This review explores how ES affects the cellular mechanisms of wound healing, and its effectiveness in treating acute and chronic wounds. Literature searches with no publication date restrictions were conducted using the Cochrane Library, Medline, Web of Science, Google Scholar and PubMed databases, and 30 full-text articles met the inclusion criteria. In vitro and in vivo experiments investigating the effect of ES on the general mechanisms of healing demonstrated increased epithelialization, fibroblast migration, and vascularity around wounds. Six in vitro studies demonstrated bactericidal effects upon exposure to alternating and pulsed current. Twelve randomized controlled trials (RCTs) investigated the effect of pulsed current on chronic wound healing. All reviewed RCTs demonstrated a larger reduction in wound size and increased healing rate when compared to control groups. In conclusion, ES therapy can contribute to improved chronic wound healing and potentially reduce the financial burden associated with wound management. However, the variations in the wound characteristics, patient demographics, and ES parameters used across studies present opportunities for systematic RCT studies in the future. Full article

(This article belongs to the Special Issue Biotechnological Approaches and Biomaterials for Enhanced Wound Healing)

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