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Medicina
Special Issues
Clinical Research and Trials in Gastroenterology and Hepatology
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Clinical Research and Trials in Gastroenterology and Hepatology

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Gastroenterology & Hepatology".

Deadline for manuscript submissions: closed (1 November 2020) | Viewed by 2418

Special Issue Editor

Dr. Atsushi Sakuraba

E-Mail Website
Guest Editor
Inflammatory Bowel Disease Center, University of Chicago Medicine, Chicago, IL 60637, USA
Interests: inflammatory bowel disease; Crohn's disease; ulcerative colitis; microscopic colitis; colon cancer; gastrointestinal endoscopy; fecal transplant; clinical trials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The field of Gastroenterology and Hepatology is rapidly evolving owing to the development of novel therapeutic drugs and advancement of the understanding of underlying mechanisms. In this Special Issue, we invite investigators to contribute original research articles, as well as review articles, that will stimulate the continuing efforts to understand the treatment, outcomes, and management of digestive diseases. Topics of interest include, but are not limited to:

  • Disease- and therapy-related outcomes;
  • Novel diagnostic approaches, including biomarkers, serology, and imaging modalities;
  • Endoscopy;
  • Clinical research and trials of biologic and non-biologic therapies;
  • Surgery and related issues.

Dr. Atsushi Sakuraba
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gastroenterology
  • hepatology
  • colon cancer
  • inflammatory bowel disease
  • GI bleed
  • gastric cancer
  • helicobacter pylori
  • celiac disease
  • liver cancer
  • Clostridioides difficile
  • clinical trial
  • endoscopy
  • colorectal surgery

Published Papers (1 paper)

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9 pages, 961 KiB  
Brief Report
Tunneled Peritoneal Catheter for Refractory Ascites in Cirrhosis: A Randomized Case-Series
by Nina Kimer, Agnete Nordheim Riedel, Lise Hobolth, Christian Mortensen, Lone Galmstrup Madsen, Mette Lehmann Andersen, Frank Vinholt Schiødt, Søren Møller and Lise Lotte Gluud
Medicina 2020, 56(11), 565; https://0-doi-org.brum.beds.ac.uk/10.3390/medicina56110565 - 27 Oct 2020
Cited by 4 | Viewed by 2018
Abstract
Background and objectives: Refractory ascites markedly worsens prognosis in cirrhosis. Large volume paracentesis (LVP) is standard treatment, but complications are common. In a randomized controlled case-series, we assessed a permanent tunneled peritoneal catheter versus LVP in patients with cirrhosis and ascites. Materials and [...] Read more.
Background and objectives: Refractory ascites markedly worsens prognosis in cirrhosis. Large volume paracentesis (LVP) is standard treatment, but complications are common. In a randomized controlled case-series, we assessed a permanent tunneled peritoneal catheter versus LVP in patients with cirrhosis and ascites. Materials and Methods: Random allocation was computer-generated, and concealment used opaque envelopes. Patients were included from January 2017 to December 2018. Inclusion criteria were cirrhosis and recurrent ascites and expected survival of more than 3 months. Results: Thirteen patients were enrolled (PleurX =6 versus LVP = 7). Seven were female, ranging in age from 51 to 80 years. No procedure-related complications occurred. Two patients died due to variceal bleeding (PleurX-group) and sepsis (LVP-group). One patient was withdrawn due to hyponatremia (PleurX-group). Two patients were withdrawn due to bacterial peritonitis and infection of unknown origin (control-group). In the PleurX-group, all patients colonized the catheter, two developed bacterial peritonitis. The most common bacterial colonization was Staph. Epidermidis (n = 4). Conclusions: In selected patients, the PleurX catheter mobilizes ascites and may be an alternative to LVP. The risk of infection should be considered in each case. The impact of colonization and risk of infections needs further investigation. The present trial does not allow for statistical conclusions. Full article
(This article belongs to the Special Issue Clinical Research and Trials in Gastroenterology and Hepatology)
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