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Medicina
Special Issues
Clinical Application and Development of Ocular Imaging
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Clinical Application and Development of Ocular Imaging

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Ophthalmology".

Deadline for manuscript submissions: closed (31 August 2022) | Viewed by 3711

Special Issue Editor

Dr. Alexandra Miere

E-Mail Website
Guest Editor
Department of Ophthalmology, Creteil Hospital, Paris Est University, Créteil, France
Interests: retinal imaging; age-related macular degeneration; retinal dystrophies; big data; artificial intelligence
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The extraordinary advancements in ocular imaging today allow a histology-like anatomical description of ocular structures, from the anterior segment to the posterior segment. The fact that these new devices provide non-invasive, high-resolution images of the eye is obviously translated into clinical eye care for a myriad of ocular pathologies. Today, the most prominent use of ophthalmic imaging devices is for retinal diseases (age-related macular degeneration, diabetic retinopathy and diabetic macular edema, central serous chorioretinopathy, retinal dystrophies, and so on) and glaucoma. As the precise visualization and quantification of the changes occurring along the disease process is essential, this has in recent years led to a paradigm shift in the detection, management, and follow-up of ophthalmological diseases.

This Special Issue aims to highlight the clinical applications and developments of ocular imaging and recent technological developments in the field, with an emphasis on the valuable biomarkers of disease progression, the reproducibility of these ocular imaging methods, the correspondence between functional tests and imaging-derived information (i.e., structure–function correlations), and insights into disease pathogenesis derived from imaging techniques.

The contributions may include a broad scope of research, for instance, recent technological developments in both anterior and posterior segment imaging, novel non-invasive ocular imaging techniques, and their clinical applications.

Dr. Alexandra Miere
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • imaging
  • OCT
  • retinal disease

Published Papers (2 papers)

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Research

9 pages, 1403 KiB  
Article
Effects of Photobiomodulation in Patients Presenting with Reticular Pseudodrusen: A Retrospective Observational Case Series Study
by Hoang Mai Le, Carl-Joe Mehanna, Irene De Rosa, Alexandra Miere and Eric Souied
Medicina 2022, 58(11), 1662; https://0-doi-org.brum.beds.ac.uk/10.3390/medicina58111662 - 17 Nov 2022
Cited by 3 | Viewed by 1749
Abstract
Background and Objectives: The purpose of this study is to describe the effects of photobiomodulation on drusen regression with patients presenting with reticular pseudodrusen (RPD). Materials and Methods: This study is a retrospective observational case series study including patients presenting with [...] Read more.
Background and Objectives: The purpose of this study is to describe the effects of photobiomodulation on drusen regression with patients presenting with reticular pseudodrusen (RPD). Materials and Methods: This study is a retrospective observational case series study including patients presenting with RPD who underwent treatment by photobiomodulation. All patients underwent a complete ophthalmic examination and multimodal imaging prior to treatment, including spectral-domain optical coherence tomography (SD-OCT). Eyes were treated two times per week for six consecutive weeks. Best corrected-visual acuity (BVCA) was measured prior and after treatment for all patients. The number of RPD on the SD-OCT scans centered on the macula and stages of RPD was noted at baseline and 6 months after the first treatment session. Results: Five eyes of five patients were included in the study. Mean BCVA did not change 6 months after treatment compared to baseline. Mean number of RPD per eye was 112.60 +/− 48.33 RPD at baseline and 111.6 +/− 49.29 in the same area 6 months after treatment. Changes in RPD distribution according to RPD classification were observed before and after treatment with photobiomodulation. Changes in distribution mostly concerned stages 1 and 3 RPD: Total number of stage 1 RPD was 289 and increased to 324 after treatment. Total number of stage 3 RPD was 97 at baseline and decreased to 67 6 months after treatment. Percentage of stage 1 RPD increased from 46% to 56% after treatment. Percentage of stage 3 RPD decreased from 20% to 13% after treatment. Conclusions: Changes in RPD distribution were observed before and after treatment with photobiomodulation. The number of stage 3 reticular pseudodrusen decreased while number of stage 1 reticular pseudodrusen increased after treatment. Full article
(This article belongs to the Special Issue Clinical Application and Development of Ocular Imaging)
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17 pages, 3276 KiB  
Article
Choroidal Assessment in Patients with Type 2 Diabetes Mellitus and Non-Proliferative Diabetic Retinopathy by Swept-Source Ocular Coherence Tomography and Image Binarization
by Otilia Obadă, Anca Delia Pantalon, Gabriela Rusu-Zota, Anca Hăisan, Smaranda Ioana Lupuşoru and Dorin Chiseliţă
Medicina 2022, 58(7), 918; https://0-doi-org.brum.beds.ac.uk/10.3390/medicina58070918 - 10 Jul 2022
Cited by 1 | Viewed by 1609
Abstract
Background and Objectives: The aim of this study was to evaluate choroidal structure and vascularity indices in patients with non-proliferative diabetic retinopathy (NPDR). Materials and Methods: Sixty-three eyes from sixty-three patients were evaluated: 21 from healthy subjects, 20 with diabetes mellitus (DM) [...] Read more.
Background and Objectives: The aim of this study was to evaluate choroidal structure and vascularity indices in patients with non-proliferative diabetic retinopathy (NPDR). Materials and Methods: Sixty-three eyes from sixty-three patients were evaluated: 21 from healthy subjects, 20 with diabetes mellitus (DM) and no diabetic retinopathy (DR), and 22 with DM and non-proliferative diabetic retinopathy without diabetic macular edema (DME). Each patient underwent ocular examination, macular swept-source ocular coherence tomography (SS-OCT) imaging, glycemic control, and systemic high blood pressure (HBP) evaluation. Subfoveal choroidal thickness (SF-CT) was manually assessed on a line scan. Line scan OCT images were exported to ImageJ program. The areas under a 1.5, 3 and 6 mm horizontal line centered on the fovea were assessed by converting the OCT images to binary images, and total choroidal area (TCA), luminal area (LA), stromal area (SA), LA:SA ratio, and choroidal vascularity index (CVI) were evaluated. SF-CT and choroidal parameters were compared between groups, and correlations with ocular and systemic factors were analyzed. Results: SF-CT, TCA, LA, and SA were similar between groups. CVIs were significantly different between groups for all three studied areas (CVI-1.5: 66.21% vs. 66.06% vs. 63.74%, p = 0.003; CVI-3: 65.88% vs. 66.46% vs. 63.79%, p = 0.008; CVI-6: 64.79% vs. 65.40% vs. 63.61%, p = 0.032). NPDR patients had significantly lower CVIs compared to DM patients (p < 0.05). No association of choroidal parameters with glycemic control, DM duration and HBP was found significant (p < 0.05). Conclusions: Choroidal assessment by SS-OCT and image binarization in healthy subjects, subjects with DM without DR, and subjects with DM and NPDR indicated that CVI changes were identifiable and significant in early DR. The lack of association with ocular and systemic factors suggest that CVIs are reliable assessment parameters of choroidal vascular structure. Full article
(This article belongs to the Special Issue Clinical Application and Development of Ocular Imaging)
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