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Medicina
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Recent Advances in the Treatment of Breast Cancer
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Recent Advances in the Treatment of Breast Cancer

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Oncology".

Deadline for manuscript submissions: closed (20 December 2021) | Viewed by 2487

Special Issue Editor

Dr. Armando Orlandi

E-Mail Website
Guest Editor
Comprehensive Cancer Center, Unit of Oncology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy
Interests: cancer biology; cancer biomarkers; clinical oncology; cell culture; immunohistochemistry; tumor markers; breast cancer; colorectal cancer; chemotherapy; oncology

Special Issue Information

Dear Colleagues,

Breast cancer is acknowledged as an international priority in healthcare. It is currently the most common cancer in women worldwide, with a continuous increase in incidence.

In recent years, cancer research has allowed us to introduce new systemic treatments into clinical practice. Nonetheless, the constant need to improve the therapeutic approach to this disease remains a target to be pursued daily in research activity.

The aim of this Special Issue is to underline the evolution of the treatment of early and advanced breast cancer through reviews of the scientific literature or meta-analyses. At the same time, this Special Issue is aimed at original papers with an exploratory nature investigating new and original therapeutic pathways.

Dr. Armando Orlandi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • target therapy
  • predictive factors
  • prognostic factors
  • hormonal therapy
  • neoadjuvant

Published Papers (1 paper)

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14 pages, 5678 KiB  
Case Report
Rosai–Dorfman Disease: Breast Involvement—Case Report and Literature Review
by George Iancu, Nicolae Gica, Laura Mihaela Mustata, Anca Maria Panaitescu, Danut Vasile and Gheorghe Peltecu
Medicina 2021, 57(11), 1167; https://0-doi-org.brum.beds.ac.uk/10.3390/medicina57111167 - 27 Oct 2021
Cited by 5 | Viewed by 2145
Abstract
Background and objectives: Rosai–Dorfman disease (RDD) is a type of histiocytosis that usually appears in young adults or children as bilateral cervical lymphadenopathy, but extranodal involvement in not uncommon. Although the pathogenesis is not entirely elucidated, recent studies showed a possible neoplastic [...] Read more.
Background and objectives: Rosai–Dorfman disease (RDD) is a type of histiocytosis that usually appears in young adults or children as bilateral cervical lymphadenopathy, but extranodal involvement in not uncommon. Although the pathogenesis is not entirely elucidated, recent studies showed a possible neoplastic process. Materials and methods: Our manuscript presents a rare case of Rosai–Dorfman disease of the breast, the management of this rare case, and a literature review. There are few cases reported of RDD of the breast (around 90 globally reported cases); the data is poor, and the management not yet standardized for these cases. The case reported here shows the importance of correct breast investigation, breast imaging, and ultrasound-guided biopsy that provided an accurate diagnosis and guided further management. Results: Although RDD of the breast was rarely presented as bilateral disease in other case reports, our case showed bilateral breast disease with the suspicion of breast cancer on imaging. Pathology and immunohistochemistry were of critical importance and showed a specific pattern for histiocytosis. A multidisciplinary approach was taken into consideration for these cases in order to establish the approach. Some patients underwent surgery, but watchful waiting and close follow-up were the preferred approach. Conclusions: RDD of the breast is a rare form of histiocytosis, with fewer than 100 globally published cases. Although the management of this disease is not established yet by guidelines, a follow-up approach should be enough for these patients, and surgery might be overtreatment. Mortality from RDD is very low due to comorbidities. A multidisciplinary team decision is important, and abstinence might significantly benefit these patients. Full article
(This article belongs to the Special Issue Recent Advances in the Treatment of Breast Cancer)
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