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Medicina
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Recent Advances in Helicobacter pylori
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Recent Advances in Helicobacter pylori

A special issue of Medicina (ISSN 1648-9144). This special issue belongs to the section "Gastroenterology & Hepatology".

Deadline for manuscript submissions: closed (30 June 2022) | Viewed by 5594

Special Issue Editor

Prof. Dr. Luis Rodrigo

E-Mail Website
Guest Editor
Hospital Universitario Central de Asturias (HUCA), Gastroenterology Unit, Oviedo, Spain
Interests: celiac disease; gluten intolerance; Helicobacter pylori; gastrointestinal tumors; liver diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Helicobacter pylori (H. pylori) is a bacterial pathogen with a record of around 50% worldwide prevalence, being the main cause of chronic gastritis, peptic ulcer disease and gastric cancer. Nevertheless, its presence is currently asymptomatic, and its finding is sometimes casual, coincidental to a variety of clinical situations. In addition, there is an inverse relationship prevalence between countries, in relation to the socio-economic level of the population.

Diagnostic methods are various. Despite the use of culture and antibiotic susceptibility, testing is not routinely performed. The treatment to prescribe and the test to confirm eradication are debatable, and recommendations have changed over time.  The ideal strategy to manage H. pylori infection remains unclear.

Most treatments are prescribed on an empiric basis, unaware of the bacterial antibiotic resistance profile. Notably, recommendations have changed over time, with a shift from triple to quadruple therapies in the last consensus conferences. Therefore, a continuous evaluation of practice outcomes using the different management options is required in order to achieve high-quality “evidence-based medicine”.

Prof. Dr. Luis Rodrigo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Medicina is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Helicobacter pylori
  • epidemiology
  • pathogenic strains
  • associated diseases
  • treatments

Published Papers (2 papers)

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Research

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13 pages, 2605 KiB  
Article
Differential Proteomics of Helicobacter pylori Isolates from Gastritis, Ulcer, and Cancer Patients: First Study from Northwest Pakistan
by Syed Ali Raza Shah, Hazir Rahman, Muhammad Qasim, Muhammad Safwan Akram, Yasemin Saygideger, Nanda Puspita, Burcu Saygıdeğer Demir, Khalid J. Alzahrani, Muhammad Fayyaz ur Rehman, Fuad M. Alzahrani and Mohamed A. Alblihd
Medicina 2022, 58(9), 1168; https://0-doi-org.brum.beds.ac.uk/10.3390/medicina58091168 - 28 Aug 2022
Viewed by 2401
Abstract
Background and Objective: Helicobacter pylori is a human-stomach-dwelling organism that causes many gastric illnesses, including gastritis, ulcer, and gastric cancer. The purpose of the study was to perform differential proteomic analysis on H. pylori isolates from gastritis, ulcer, and gastric cancer patients. [...] Read more.
Background and Objective: Helicobacter pylori is a human-stomach-dwelling organism that causes many gastric illnesses, including gastritis, ulcer, and gastric cancer. The purpose of the study was to perform differential proteomic analysis on H. pylori isolates from gastritis, ulcer, and gastric cancer patients. Materials and Methods: H. pylori was isolated from antrum and fundus biopsies obtained from patients who visited the Department of Gastroenterology. Using nano-LC-QTOF MS/MS analysis, differentially regulated proteins were identified through proteome profiling of pooled samples of H. pylori isolated from gastritis, ulcer, and gastric cancer patients. Antigenic scores and cellular localization of proteins were determined using additional prediction tools. Results: A total of 14 significantly regulated proteins were identified in H. pylori isolated from patients with either gastritis, ulcer, or gastric cancer. Comparative analysis of groups revealed that in the case of cancer vs. gastritis, six proteins were overexpressed, out of which two proteins, including hydrogenase maturation factor (hypA) and nucleoside diphosphate kinase (ndk) involved in bacterial colonization, were only upregulated in isolates from cancer patients. Similarly, in cancer vs. ulcer, a total of nine proteins were expressed. Sec-independent protein translocase protein (tatB), involved in protein translocation, and pseudaminic acid synthase I (pseI), involved in the synthesis of functional flagella, were upregulated in cancer, while hypA and ndk were downregulated. In ulcer vs. gastritis, eight proteins were expressed. In this group, tatB was overexpressed. A reduction in thioredoxin peroxidase (bacterioferritin co-migratory protein (bcp)) was observed in ulcer vs. gastritis and cancer vs. ulcer. Conclusion: Our study suggested three discrete protein signatures, hypA, tatB, and bcp, with differential expression in gastritis, ulcer, and cancer. Protein expression profiles of H. pylori isolated from patients with these gastric diseases will help to understand the virulence and pathogenesis of H. pylori. Full article
(This article belongs to the Special Issue Recent Advances in Helicobacter pylori)
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Review

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16 pages, 2863 KiB  
Review
Helicobacterpylori Infection—A Risk Factor for Irritable Bowel Syndrome? An Updated Systematic Review and Meta-Analysis
by Ziyan Wang, Yuhua Liu, Yinglong Peng and Liang Peng
Medicina 2022, 58(8), 1035; https://0-doi-org.brum.beds.ac.uk/10.3390/medicina58081035 - 02 Aug 2022
Cited by 4 | Viewed by 2128
Abstract
Nowadays, the relationship between Helicobacter pylori infection (HPI) and irritable bowel syndrome (IBS) remains controversial. Objective: The aim of this study is to investigate the relationship between HPI and IBS through a systematic review and meta-analysis based on the current evidence. Methods: We [...] Read more.
Nowadays, the relationship between Helicobacter pylori infection (HPI) and irritable bowel syndrome (IBS) remains controversial. Objective: The aim of this study is to investigate the relationship between HPI and IBS through a systematic review and meta-analysis based on the current evidence. Methods: We performed a systematic literature search in electronic databases (PubMed, EMBASE, and the Cochrane library) by computer to identify all reports published before 8 August 2021. The odds ratio (OR) and confidence interval (CI) were calculated to evaluate the association between HPI and IBS. Subgroup analyses were conducted for further assessment and exploration of heterogeneity sources. In addition, we assessed publication bias through funnel plots, Egger’s test, and Begg’s test. Finally, we conducted a sensitivity analysis to evaluate the robustness of the results. Results: Thirteen studies with 13,173 participants were included in the meta-analysis. The pooled OR of the association between HPI and IBS was 1.03 (95% CI [0.80,1.31]; p = 0.84). The adjusted OR of the association between HPI and IBS after excluding the studies with confounding factors defined by our team was 1.29 (95% CI [1.03,1.62]; p = 0.03). We found a positive association between HPI and IBS-D (diarrhea subtype) (OR: 1.54; 95% CI [1.22,1.95]; p = 0.0003). The OR of the relationship between cytotoxin-associated gene A (Cag A) positive HPI and IBS was 4.3 (95% CI [0.51,36.17]; p = 0.18). Conclusions: The likelihood of HPI in IBS patients is relatively higher than that of non-IBS participants but not statistically significant, implying that HPI is not significantly associated with IBS, albeit we may underestimate this association. Moreover, we found a positive association between HPI and IBS-D. We also observed an increased likelihood of Cag-A positive HPI in IBS patients than that of non-IBS participants but not statistically significant. Full article
(This article belongs to the Special Issue Recent Advances in Helicobacter pylori)
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