Dear Colleagues,

Numerous metabolites significantly contribute to the regulation of immune responses. Their modes of action can vary widely, ranging from immune activation to the termination of inflammation, the suppression of responses, and the mediation of tolerance.  A key example is cytokine interferon-gamma, which affects a variety of metabolic pathways. In this context, immune-mediated tryptophan catabolism along the kynurenine axis is probably one of the most reviewed metabolic pathways, with clinical relevance in chronic immunopathologies. However, several other metabolite classes are co-regulated with cytokine responses, linking, e.g., altered nutrient and energy metabolism to immunological processes relevant to disease.  In this Special Issue, metabolites that influence immunological regulatory circuits and have clinical relevance, e.g., as potential drug targets, or with predictive or prognostic significance, are presented. These may include but are not limited to amino acids and derivatives, biogenic amines, lipid classes, pteridines, and signaling gases. Clinical and translational studies as well as basic experimental research will be covered.

Prof. Dr. Johanna M. Gostner
Prof. Dr. Bohuslav Melichar
Prof. Dr. Dietmar Fuchs
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• immunometabolism
• (metabolite) biomarker
• immunoregulation
• crosstalk of immunity and metabolism
• clinical relevance
• immunobiochemistry