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Metabolites
Special Issues
Effects of Dietary Supplementation in Metabolic Syndrome
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Effects of Dietary Supplementation in Metabolic Syndrome

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 3765

Special Issue Editors

Prof. Dr. M. Dulce Estêvão

E-Mail Website
Guest Editor
CCMAR—Centre of Marine Sciences and School of Health, University of Algarve, Faro, Portugal
Interests: fish mineralized tissues; calcium metabolism; endocrine disruption; estrogen/estrogen receptors; phytoestrogens; systematic reviews
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Manuela Meireles

E-Mail Website
Guest Editor
1. Centro de Investigação de Montanha (CIMO), Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal
2. Laboratório para a Sustentabilidade e Tecnologia em Regiões de Montanha, Instituto Politécnico de Bragança, Campus de Santa Apolónia, 5300-253 Bragança, Portugal
Interests: nutrition; polyphenols; functional food; obesity; diabetes; metabolic syndrome

Special Issue Information

Dear Colleagues,

Metabolic syndrome is a serious health issue that represents a relevant social and economic burden in society. It includes a range of metabolic disorders, such as obesity, type 2 diabetes mellitus, dyslipidemia, atherosclerosis, and hypertension, which constitute risk factors for cardiovascular diseases.

Metabolic syndrome is still not fully understood, and researchers continue to work to try to unravel the many factors that contribute to its complexity. Molecular mechanisms associated with its development and progression, predisposing genetic factors, the type of diet, and other lifestyle changes are examples of topics that continue to be studied to try to prevent and treat the metabolic syndrome.

In particular, the effect of the various molecules that make up food, whether as natural ingredients or added in the form of supplements, is a current topic with much knowledge to be explored.

This Special Issue will therefore include a wide range of papers in the various areas that can contribute to improving our levels of knowledge about metabolic syndrome and the different ways to prevent or treat it, with a special emphasis on the effects of dietary supplementation.

We invite you to submit papers (original papers and/or reviews) related to your most recent research that may contribute to the objectives of this Special Issue on the effects of dietary supplementation in metabolic syndrome.

Prof. Dr. M. Dulce Estêvão
Prof. Dr. Manuela Meireles
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • atherosclerosis
  • cancer
  • cardiovascular diseases
  • community nutrition
  • diabetes
  • dietary assessment tools
  • dietary patterns
  • dietary strategies
  • dietary supplements
  • food supplements
  • dyslipidemia
  • hypertension
  • insulin resistance
  • lifestyle medicine
  • metabolic syndrome
  • metabolic biomarkers
  • microbiota
  • molecular mechanisms
  • obesity
  • prebiotics
  • probiotics
  • risk factors

Published Papers (2 papers)

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Research

15 pages, 2094 KiB  
Article
Capsicum baccatum Red Pepper Prevents Cardiometabolic Risk in Rats Fed with an Ultra-Processed Diet
by Aline Rigon Zimmer, Bianca Franco Leonardi, Eduardo Rigon Zimmer, Alexandre Pastoris Muller, Grace Gosmann and Luis Valmor Cruz Portela
Metabolites 2023, 13(3), 385; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo13030385 - 05 Mar 2023
Viewed by 1444
Abstract
Metabolic syndrome is a serious health condition reaching epidemic proportions worldwide and is closely linked to an increased risk of cardiovascular problems. The lack of appropriate treatment paves the way for developing new therapeutic agents as a high priority in the current research. [...] Read more.
Metabolic syndrome is a serious health condition reaching epidemic proportions worldwide and is closely linked to an increased risk of cardiovascular problems. The lack of appropriate treatment paves the way for developing new therapeutic agents as a high priority in the current research. In this study, we evaluated the protective effects of Capsicum baccatum red pepper on metabolic syndrome scenarios induced by an ultra-processed diet in rats. After four months, the ultra-processed diet increased central obesity, triglycerides, total cholesterol, LDL-cholesterol plasma levels, and impaired glucose tolerance. The oral administration of C. baccatum concomitantly with the ultra-processed diet avoided the accumulation of adipose tissue in the visceral region, reduced the total cholesterol and LDL fraction, and improved glucose homeostasis, factors commonly associated with metabolic syndrome. The data presented herein reveal an important preventive action of C. baccatum in developing metabolic disorders among animals fed a hypercaloric diet, significantly reducing their cardiometabolic risk. Allied with the absence of toxic effects after chronic use, our study suggests C. baccatum red pepper as a secure and enriched source of bioactive compounds promising to protect against pathological processes associated with metabolic syndrome. Full article
(This article belongs to the Special Issue Effects of Dietary Supplementation in Metabolic Syndrome)
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13 pages, 1411 KiB  
Article
Effects of a Calorie-Restricted Cafeteria Diet and Oleuropein Supplementation on Adiposity and mRNA Expression of Energy Balance Related Genes in Obese Male Rats
by Alex Subias-Gusils, Adam Álvarez-Monell, Noemi Boqué, Antoni Caimari, Roger Mariné-Casadó, Rosa M. Escorihuela and Montserrat Solanas
Metabolites 2023, 13(2), 147; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo13020147 - 18 Jan 2023
Cited by 2 | Viewed by 1450
Abstract
Supplementation with natural bioactive compounds has been proposed to be a complementary tool to the calorie-restricted diets and physical exercise programs used to tackle human overweight, obesity and Metabolic syndrome. Herein, we evaluated the effects of 14 weeks of calorie-restricted cafeteria diet either [...] Read more.
Supplementation with natural bioactive compounds has been proposed to be a complementary tool to the calorie-restricted diets and physical exercise programs used to tackle human overweight, obesity and Metabolic syndrome. Herein, we evaluated the effects of 14 weeks of calorie-restricted cafeteria diet either alone or combined with oral administration of the polyphenol oleuropein in obese adult male rats, compared with a control group fed standard chow and a group fed cafeteria diet. Animals were sacrificed at the age of 26 weeks and several tissues of interest were removed. The results showed that both dietary interventions reduced the adiposity index (p < 0.05 and p < 0.01, respectively), and specifically the abdominal fat depots (mesenteric: p < 0.01 and p < 0.01, respectively; and epididymal: both diets p < 0.001) and restored the decreased soleus skeletal muscle mass. Both interventions decreased leptin mRNA expression in mesenteric white adipose tissue (p < 0.05) and normalized hypothalamic Agrp mRNA expression compared to cafeteria-fed obese rats (p < 0.05). However, only the calorie-restricted cafeteria diet supplemented with oleuropein induced additional lower retroperitoneal adipose accretion (p < 0.05) and increased hypothalamic leptin receptor mRNA levels (p < 0.05). Experiments with female animals, at different doses and longer intervention periods, are needed to better determine the potential benefits of this dietary treatment. Full article
(This article belongs to the Special Issue Effects of Dietary Supplementation in Metabolic Syndrome)
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