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Metabolites
Special Issues
Advances in Salivary Metabolomics for Oral and Systemic Diseases
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Advances in Salivary Metabolomics for Oral and Systemic Diseases

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 576

Special Issue Editor

Prof. Dr. Arja Kullaa

E-Mail Website
Guest Editor
Oral Medicine, Univeristy of Eastern Finland, 1, 70210 Kuopio, Finland
Interests: oral diseases; oral cancer; salivary metabolites; metabolomics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Salivary metabolomics has gained ground in the research of oral and general diseases. Measuring salivary metabolites as diagnostic biomarkers is becoming increasingly popular. However, two aspects of metabolites should be considered: 1) what diseases they indicate (diagnostics) and 2) what changes they cause (pathological pathways). Saliva contains a wide variety of metabolites that are either final products of oral metabolism or derived from salivary glands. Salivary metabolites are mainly derived from oral microbes, of which there are millions in the oral cavity. Oral micro-organisms produce metabolites that can be combined with various oral inflammatory diseases. Furthermore, salivary metabolites may give more information about metabolic processes in the oral cavity and different oral diseases. The association between oral diseases and systemic diseases is supported by epidemiological, clinical, pharmacological, and genetic studies, but also by some omics studies. Salivary metabolites are related to various general diseases, not only diagnostically. Metabolic profiling of saliva opens up a whole new world to understand the physiology of the mouth, different oral diseases and the effects of oral metabolites on the whole human body. That is why we need such Special Issues to summarize the latest research data on salivary metabolites.

Prof. Dr. Arja Kullaa
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolomics
  • salivary metabolites
  • oral diseases
  • oral cancer
  • periodontal diseases
  • oral microbiome
  • systemic diseases

Published Papers (1 paper)

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Research

12 pages, 1326 KiB  
Article
Salivary Tryptophan as a Metabolic Marker of HER2-Negative Molecular Subtypes of Breast Cancer
by Elena A. Sarf, Elena I. Dyachenko and Lyudmila V. Bel’skaya
Metabolites 2024, 14(5), 247; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo14050247 - 25 Apr 2024
Viewed by 232
Abstract
Changes in the concentration of tryptophan (Trp) indicate a serious metabolic restructuring, which is both a cause and a consequence of many diseases. This work examines the upward change in salivary Trp concentrations among patients with breast cancer. This study involved volunteers divided [...] Read more.
Changes in the concentration of tryptophan (Trp) indicate a serious metabolic restructuring, which is both a cause and a consequence of many diseases. This work examines the upward change in salivary Trp concentrations among patients with breast cancer. This study involved volunteers divided into three groups: breast cancer (n = 104), non-malignant breast pathologies (n = 30) and healthy controls (n = 20). In all participants, before treatment, the quantitative content of Trp in saliva was determined by capillary electrophoresis. In 20 patients with breast cancer, Trp was re-tested four weeks after surgical removal of the tumor. An increase in the Trp content in saliva in breast cancer has been shown, which statistically significantly decreases after surgical removal of the tumor. A direct correlation was found between increased Trp levels with the degree of malignancy and aggressive molecular subtypes of breast cancer, namely triple negative and luminal B-like HER2-negative. These conclusions were based on an increase in Ki-67 and an increase in Trp in HER2-negative and progesterone-negative subtypes. Factors under which an increase in Trp concentration in saliva was observed were identified: advanced stage of breast cancer, the presence of regional metastasis, low tumor differentiation, a lack of expression of HER2, estrogen and progesterone receptors and the high proliferative activity of the tumor. Thus, the determination of salivary Trp may be a valuable tool in the study of metabolic changes associated with cancer, particularly breast cancer. Full article
(This article belongs to the Special Issue Advances in Salivary Metabolomics for Oral and Systemic Diseases)
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