New Insights into Gut Microbiota and Obesity

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: 25 May 2024 | Viewed by 1592

Special Issue Editor


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Guest Editor
Departemnt of Internal Medicine, Evangelismos General Hospital, Athens, Greece
Interests: infectious diseases; diabetes; obesity; microbiome
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Special Issue Information

Dear Colleagues,

The role of the gut microbiota in health seems to be important and multifaceted. The human gut microbiota begins in utero and continues to be shaped throughout life under the influence of various factors, such as diet, drugs administration and the aging process. On the other hand, obesity and obesity-related disorders pose a major public health issue world widely.

In this Special Issue, we will focus upon the interplay of diet, nutritional aspects and various metabolic biomarkers, which are produced by the gut microbiota in response to dietary factors. The scope of this Issue will be to emphasize the importance of healthier diets with regard to the gut microbiome as a venue to combat obesity and obesity-related disorders. The purpose will be to point out the significance and beneficial efficacy of probiotics, prebiotics, synbiotics and postbiotics as well as the potential of next-generation probiotics in this context. The therapeutic potential of next-generation probiotics as well as the pros and cons of these promising agents will be further discussed. In addition, the difficulties in research for possible next-generation probiotics together with the diagnostic difficulties regarding the composition of the gut microbiota in the multi-omics era will be elucidated in this Special Issue

Dr. Natalia G. Vallianou
Guest Editor

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Keywords

  • gut microbiota
  • obesity
  • diet
  • metabolomics
  • probiotics
  • prebiotics

Published Papers (1 paper)

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17 pages, 2212 KiB  
Article
Intestinal Dysbiosis in Subjects with Obesity from Western Mexico and Its Association with a Proinflammatory Profile and Disturbances of Folate (B9) and Carbohydrate Metabolism
by Verónica Riggen-Bueno, Susana Del Toro-Arreola, Tonatiuh Abimael Baltazar-Díaz, Alejandra N. Vega-Magaña, Marcela Peña-Rodríguez, Paula Alejandra Castaño-Jiménez, Laura Verónica Sánchez-Orozco, José María Vera-Cruz and Miriam Ruth Bueno-Topete
Metabolites 2024, 14(2), 121; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo14020121 - 11 Feb 2024
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Abstract
Obesity is a public health problem with a growing prevalence worldwide. In Mexico, it is estimated that one out of three adults suffer from obesity. In these patients, the intestinal microbiota (IM) undergoes pathological changes that are associated with a dysbiotic state; however, [...] Read more.
Obesity is a public health problem with a growing prevalence worldwide. In Mexico, it is estimated that one out of three adults suffer from obesity. In these patients, the intestinal microbiota (IM) undergoes pathological changes that are associated with a dysbiotic state; however, the microbiota profile of adult subjects with obesity from western Mexico has not been described. To assess this, fecal samples were obtained from 65 participants (Obese = 38; Control = 27). The microbial composition was characterized by 16S rRNA amplicon sequencing. The IM of the group with obesity revealed a clear decrease in richness and diversity (p < 0.001), as well as a significant increase in proinflammatory bacterial groups, mainly genera belonging to the Negativicutes class, Escherichia/Shigella, and Prevotella. Likewise, an increase in short-chain fatty acid-producing bacteria was found, especially the genus Lachnoclostridium. Additionally, PICRUSt2 analysis showed a depletion of vitamin B9 metabolism and an increase in saccharolytic pathways. The IM of patients with obesity possesses a dysbiotic, proinflammatory environment, possibly contributing to lipogenesis and adiposity. Thus, assessing the IM will allow for a better understanding of the pathophysiology of metabolic diseases of high prevalence, such as obesity. These findings are described for the first time in the adult population of western Mexico. Full article
(This article belongs to the Special Issue New Insights into Gut Microbiota and Obesity)
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