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Metabolites
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Energy Metabolism in the Central Nervous System
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Energy Metabolism in the Central Nervous System

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (28 February 2022) | Viewed by 7069

Special Issue Editor

Dr. Teodoro Bottiglieri

E-Mail Website
Guest Editor
Scott and White, Center of Metabolomics, Temple, TX 76712, USA
Interests: homocysteine metabolism; folate; vitamin B12 and one-carbon metabolism; regulation of S-adenosylmethionine and methylation in metabolic disorders; amino acid metabolism energy metabolism in the central nervous system; inherited disorders affecting neurotransmitter metabolism; risk factors for vascular and neurodegenerative diseases
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Energy metabolism is a critical process and an essential requirement for all living cells. No organ can be spared from a lack of ATP production, the principle energy molecule that drives a plethora of cellular reactions. The central nervous system (CNS) is no exception, and is perhaps the most sensitive to the oxygen deprivation and glucose restriction that affect synthesis of ATP and the production and utilization of this energy source. This Special Issue of Metabolites, “Energy Metabolism in the Central Nervous System”, will be dedicated to research that can further our understanding of the role that energy metabolism plays in maintaining normal and healthy brain function. The topics that will be covered by this Special Issue include but are not limited to neurodegenerative diseases, psychiatric disorders, malignancies of the CNS, inherited metabolic diseases affecting the CNS, dietary supplements, and pharmacological agents that affect energy metabolism in the CNS.  Methodological techniques to study energy metabolism in the CNS are also highly desired.

Dr. Teodoro Bottiglieri
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Central nervous system
  • Energy metabolism
  • ATP
  • Neurodegeneration
  • Psychiatric illness
  • CNS malignancies
  • Inherited diseases
  • Dietary deficiencies
  • Dietary supplements
  • Pharmacological agents

Published Papers (2 papers)

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Research

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15 pages, 2014 KiB  
Article
Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans
by Paula Valente-Silva, Igor Cervenka, Duarte M. S. Ferreira, Jorge C. Correia, Sebastian Edman, Oscar Horwath, Benjamin Heng, Sharron Chow, Kelly R. Jacobs, Gilles J. Guillemin, Eva Blomstrand and Jorge L. Ruas
Metabolites 2021, 11(8), 508; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo11080508 - 03 Aug 2021
Cited by 11 | Viewed by 4501
Abstract
The kynurenine pathway of tryptophan (TRP) degradation (KP) generates metabolites with effects on metabolism, immunity, and mental health. Endurance exercise training can change KP metabolites by changing the levels of KP enzymes in skeletal muscle. This leads to a metabolite pattern that favors [...] Read more.
The kynurenine pathway of tryptophan (TRP) degradation (KP) generates metabolites with effects on metabolism, immunity, and mental health. Endurance exercise training can change KP metabolites by changing the levels of KP enzymes in skeletal muscle. This leads to a metabolite pattern that favors energy expenditure and an anti-inflammatory immune cell profile and reduces neurotoxic metabolites. Here, we aimed to understand if TRP supplementation in untrained vs. trained subjects affects KP metabolite levels and biological effects. Our data show that chronic TRP supplementation in mice increases all KP metabolites in circulation, and that exercise reduces the neurotoxic branch of the pathway. However, in addition to increasing wheel running, we did not observe other effects of TRP supplementation on training adaptations, energy metabolism or behavior in mice. A similar increase in KP metabolites was seen in trained vs. untrained human volunteers that took a TRP drink while performing a bout of aerobic exercise. With this acute TRP administration, TRP and KYN were higher in the trained vs. the untrained group. Considering the many biological effects of the KP, which can lead to beneficial or deleterious effects to health, our data encourage future studies of the crosstalk between TRP supplementation and physical exercise. Full article
(This article belongs to the Special Issue Energy Metabolism in the Central Nervous System)
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Review

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17 pages, 1318 KiB  
Review
CSF Metabolomics of Tuberculous Meningitis: A Review
by Shayne Mason and Regan Solomons
Metabolites 2021, 11(10), 661; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo11100661 - 28 Sep 2021
Cited by 8 | Viewed by 1949
Abstract
From the World Health Organization’s global TB report for 2020, it is estimated that in 2019 at least 80,000 children (a particularly vulnerable population) developed tuberculous meningitis (TBM)—an invariably fatal disease if untreated—although this is likely an underestimate. As our latest technologies have [...] Read more.
From the World Health Organization’s global TB report for 2020, it is estimated that in 2019 at least 80,000 children (a particularly vulnerable population) developed tuberculous meningitis (TBM)—an invariably fatal disease if untreated—although this is likely an underestimate. As our latest technologies have evolved—with the unprecedented development of the various “omics” disciplines—a mountain of new data on infectious diseases have been created. However, our knowledge and understanding of infectious diseases are still trying to keep pace. Metabolites offer much biological information, but the insights they permit can be difficult to derive. This review summarizes current metabolomics studies on cerebrospinal fluid (CSF) from TBM cases and collates the metabolic data reported. Collectively, CSF metabolomics studies have identified five classes of metabolites that characterize TBM: amino acids, organic acids, nucleotides, carbohydrates, and “other”. Taken holistically, the information given in this review serves to promote the mechanistic action of hypothesis generation that will drive and direct future studies on TBM. Full article
(This article belongs to the Special Issue Energy Metabolism in the Central Nervous System)
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