Dear Colleagues,

The incidence of age-related disorders, specifically neurodegenerative diseases, has been on the rise in correlation with the increase in life expectancy observed over the past century. Diseases such as Alzheimer's, Parkinson's, Huntington's, and multiple sclerosis are chronic conditions characterized by the progressive loss of neurons in various motor, sensory, or cognitive systems. A growing body of evidence suggests a strong link between metabolic dysregulation and the pathogenesis of neurodegeneration. Metabolic changes, such as alterations in energy metabolism, oxidative stress, and mitochondrial dysfunction, have emerged as key contributors to the neurodegenerative process. These metabolic disturbances can disrupt cellular homeostasis, impair neuronal function, and ultimately lead to neuronal death. Understanding the intricate interplay between metabolic alterations and neurodegeneration is of the utmost importance in unraveling the underlying mechanisms of these age-related disorders and identifying potential therapeutic targets.

This Special Issue will highlight new insights into energy metabolism in neurodegenerative diseases. Moreover, studies that focus on the identification of biomarkers, therapeutic targets, and future treatments related to metabolic pathways are also welcome.

Dr. Marta Tomczyk
Dr. Magdalena Podlacha
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• energy metabolism
• neurodegeneration
• neurodegenerative disease
• Alzheimer’s disease
• Parkinson’s disease
• Huntington’s disease
• amyotrophic lateral sclerosis
• spinal muscular atrophy
• Lewy body disease
• multiple sclerosis