Interplay between Nutrient and Metabolic Signaling in Cell Identity

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Cell Metabolism".

Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 4033

Special Issue Editor


E-Mail Website
Guest Editor
Department of Medical Sciences and Institute of Biomedicine—iBiMED, University of Aveiro, 3810-193 Aveiro, Portugal
Interests: cancer metabolism; ageing; stem cells biology; regenerative biology; metabolic signaling

Special Issue Information

Dear Colleagues,

High-throughput analysis has deepened our understanding on the metabolic flux and pathways required for cellular proliferation, energy production, and homeostasis. Recent advances have highlighted the contribution of metabolites as signaling molecules influencing the genome and epigenome of cells.

The metabolic programming of a cellular state represents a fine balance between the intrinsic needs and the constraints imposed by the extrinsic conditions. Systemic nutrition and diet can affect the environment within tissues and organisms and modulate nutrient availability and utilization by cells, and on the other hand, the cellular metabolic state convey changes within its environment. This two-way metabolic communication has deep implications for cell identity and can potentially be modulated for the design of improved therapeutic strategies.

Therefore, this Special Issue of Metabolites will be dedicated to publishing current advances on the interplay between nutrient and metabolic signaling in cell identity, self-renewal, plasticity, cell signaling, and cell to cell communication, with important implications for cancer and regeneration in aging and disease. Manuscripts dealing with other challenging issues are also desired.

Dr. Sandrina Nóbrega-Pereira
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolites
  • nutrition
  • energy production
  • epigenome
  • cellular signaling
  • cell identity
  • cancer
  • aging
  • stem cells
  • therapy

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

26 pages, 2553 KiB  
Review
Metabolic Determinants in Cardiomyocyte Function and Heart Regenerative Strategies
by Magda Correia, Francisco Santos, Rita da Silva Ferreira, Rita Ferreira, Bruno Bernardes de Jesus and Sandrina Nóbrega-Pereira
Metabolites 2022, 12(6), 500; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo12060500 - 31 May 2022
Cited by 5 | Viewed by 3690
Abstract
Heart disease is the leading cause of mortality in developed countries. The associated pathology is characterized by a loss of cardiomyocytes that leads, eventually, to heart failure. In this context, several cardiac regenerative strategies have been developed, but they still lack clinical effectiveness. [...] Read more.
Heart disease is the leading cause of mortality in developed countries. The associated pathology is characterized by a loss of cardiomyocytes that leads, eventually, to heart failure. In this context, several cardiac regenerative strategies have been developed, but they still lack clinical effectiveness. The mammalian neonatal heart is capable of substantial regeneration following injury, but this capacity is lost at postnatal stages when cardiomyocytes become terminally differentiated and transit to the fetal metabolic switch. Cardiomyocytes are metabolically versatile cells capable of using an array of fuel sources, and the metabolism of cardiomyocytes suffers extended reprogramming after injury. Apart from energetic sources, metabolites are emerging regulators of epigenetic programs driving cell pluripotency and differentiation. Thus, understanding the metabolic determinants that regulate cardiomyocyte maturation and function is key for unlocking future metabolic interventions for cardiac regeneration. In this review, we will discuss the emerging role of metabolism and nutrient signaling in cardiomyocyte function and repair, as well as whether exploiting this axis could potentiate current cellular regenerative strategies for the mammalian heart. Full article
(This article belongs to the Special Issue Interplay between Nutrient and Metabolic Signaling in Cell Identity)
Show Figures

Figure 1

Back to TopTop