Recent Advances in Metabolic Profiling of Prostate Cancer

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (15 August 2022) | Viewed by 3920

Special Issue Editor


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Guest Editor
1. Cancer Genomics Group, International Centre for Genetic Engineering and Biotechnology, Cape Town, South Africa
2. Institute for Reproductive and Developmental Biology, Imperial College, London, UK
Interests: metabolomics; NMR spectroscopy; machine learning
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Special Issue Information

Dear Colleagues,

Metabolic profiling has greatly contributed to a deeper understanding of altered biochemical networks and pathways in prostate cancer. Cellular metabolism plays a key role in cancer proliferation. The accelerated growth rate of cancer cells is achieved by the modulation of physiological metabolic pathways, allowing a greater nutrient uptake and an increased macromolecular synthesis.

Specific genetic alterations appear to drive unique metabolic programs. These, in turn, can be used as biomarkers of genetic subtypes of prostate cancer, with implications for the development of metabolic diagnostics and precision medicine.

This Special Issue is devoted to “Recent Advances in Metabolic Profiling of Prostate Cancer”, and topics will include (but are not restricted to) the following:

- Precision medicine based on the metabolic analysis of biofluids;

- Cellular metabolism in cancer cells;

- Molecular signaling leading to a modulation of metabolic pathways;

- Metabolic profiling of understudied populations.

Dr. Stefano Cacciatore
Guest Editor

Manuscript Submission Information

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Keywords

  • Metabolomics
  • Prostate Cancer
  • Precision Medicine
  • Biomarker Discovery
  • Cancer Metabolism

Published Papers (1 paper)

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Review

17 pages, 896 KiB  
Review
Fatty Acid Metabolism Reprogramming in Advanced Prostate Cancer
by Huan Xu, Yanbo Chen, Meng Gu, Chong Liu, Qi Chen, Ming Zhan and Zhong Wang
Metabolites 2021, 11(11), 765; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo11110765 - 09 Nov 2021
Cited by 24 | Viewed by 3464
Abstract
Prostate cancer (PCa) is a carcinoma in which fatty acids are abundant. Fatty acid metabolism is rewired during PCa development. Although PCa can be treated with hormone therapy, after prolonged treatment, castration-resistant prostate cancer can develop and can lead to increased mortality. Changes [...] Read more.
Prostate cancer (PCa) is a carcinoma in which fatty acids are abundant. Fatty acid metabolism is rewired during PCa development. Although PCa can be treated with hormone therapy, after prolonged treatment, castration-resistant prostate cancer can develop and can lead to increased mortality. Changes to fatty acid metabolism occur systemically and locally in prostate cancer patients, and understanding these changes may lead to individualized treatments, especially in advanced, castration-resistant prostate cancers. The fatty acid metabolic changes are not merely reflective of oncogenic activity, but in many cases, these represent a critical factor in cancer initiation and development. In this review, we analyzed the literature regarding systemic changes to fatty acid metabolism in PCa patients and how these changes relate to obesity, diet, circulating metabolites, and peri-prostatic adipose tissue. We also analyzed cellular fatty acid metabolism in prostate cancer, including fatty acid uptake, de novo lipogenesis, fatty acid elongation, and oxidation. This review broadens our view of fatty acid switches in PCa and presents potential candidates for PCa treatment and diagnosis. Full article
(This article belongs to the Special Issue Recent Advances in Metabolic Profiling of Prostate Cancer)
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