Dear Colleagues,

Background. Metabolic syndrome aggregates diseases sharing the same pathophysiological pathways: insulin resistance, hyperinsulinemia, chronic low-grade inflammation, and neurohormonal activation. The definition of metabolic syndrome has varied since it was first described by Reaven in 1988, but the diagnostic criteria have always included central obesity, dysglycemia, high blood pressure, hypertriglyceridemia, and hypo-HDL cholesterolemia. Metabolic syndrome helps identify individuals with high cardiovascular risk, which is higher than the sum of cardiovascular risk given by each component. With the increasing prevalence of obesity, metabolic syndrome is also rising alarmingly, adding to the immense cardiovascular burden. At present, even if the diagnosis is made by having any three criteria out of five, it is considered a multifaceted condition, which includes fatty liver disease, obstructive sleep apnea, procoagulant status, microbiota changes and even cognitive impairment. The therapy for metabolic syndrome should be a holistic approach to its components. Lifestyle interventions are key therapeutic strategies for metabolic syndrome, and aim to enhance the effects of pharmacotherapy.

Aims. This Special Issue of Metabolites on “Lifestyle Interventions: A Challenging Therapeutic Strategy for Metabolic Syndrome 2nd Edition” focuses on potential lifestyle interventions that may influence metabolic syndrome and its components. Studies on dietary interventions (dietary patterns, circadian time feeding, intermittent fasting, use of supplements, nutraceuticals, and functional foods), physical activity, sleep (sleep apnea, circadian sleep disorders (sleep deprivation, sleep length, night shifts, jet lag)), microbiota changes through either diet or sleep interventions and nutritional interactions with medical therapy will be considered. Original research articles as well as reviews and meta-analyses related to topics including, but not limited to, those mentioned above will be considered for peer review.

Dr. Alina Delia Popa
Dr. Otilia Nita
Dr. Lidia Iuliana Arhire
Prof. Dr. Mariana Graur
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• diabetes
• metabolic syndrome
• insulin resistance
• obesity