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Metabolites
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Targeted Analysis and Quantification of Metabolites and Lipids in Plants,...
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Targeted Analysis and Quantification of Metabolites and Lipids in Plants, Mammals or Bioorganisms Using Metabolomics

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Lipid Metabolism".

Deadline for manuscript submissions: closed (31 August 2021) | Viewed by 5136

Special Issue Editors

Dr. Justine Bertrand-Michel

E-Mail Website1 Website2
Guest Editor
National Infrastructure of Metabolomics and Fluxomics MetaboHUB-MetatToul, Inserm, Toulouse, France
Interests: lipidomics; metabolomics; health; facility
Dr. Olivier Berdeaux

E-Mail Website
Guest Editor
INRAE, ChemoSens Platform, Centre for Taste and Feeding Behaviour (CSGA), Dijon, France
Interests: lipidomic; food; health; facility
Dr. Hector Gallart-Ayala

E-Mail Website
Guest Editor
Metabolomics Platform, University of Lausanne, 1015 Lausanne, Switzerland
Interests: targeted metabolomics/lipidomics; quantification; mass spectrometry; human population studies

Special Issue Information

Dear Colleagues,

We are pleased to announce a Special Issue of the journal Metabolites entitled “Targeted Analysis and Quantification of Metabolites and Lipids in Plants, Mammals or Bioorganisms Using Metabolomics”. Metabolomics and lipidomics have contributed significantly to our knowledge of many physiological processes such as plant growth, viral infection mechanisms, neuronal pathologies, autoimmune diseases, diabetes, obesity, and cancer. Together with other omics technologies, they can provide a holistic view at a cellular, tissue, or systemic level. This issue will aim to incorporate novel and review papers which will address two important challenges: the detection of minor polar or apolar compounds usually achieved using targeted methods and the provision of quantitative analysis. In relation to these challenges, we are interested in all affected fields: from plant to health and to biotechnology. 

Papers will be published upon acceptance and assembled in the Special Issue in 2021.

Dr. Justine Bertrand-Michel
Dr. Olivier Berdeaux
Dr. Hector Gallart-Ayala
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolomics
  • lipidomics
  • quantification
  • targeted metabolomics

Published Papers (2 papers)

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Research

17 pages, 1562 KiB  
Article
Grape Lipidomics: An Extensive Profiling thorough UHPLC-MS/MS Method
by Domenico Masuero, Domen Škrab, Giulia Chitarrini, Mar Garcia-Aloy, Pietro Franceschi, Paolo Sivilotti, Graziano Guella and Urska Vrhovsek
Metabolites 2021, 11(12), 827; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo11120827 - 30 Nov 2021
Cited by 6 | Viewed by 2207
Abstract
Lipids play many essential roles in living organisms, which accounts for the great diversity of these amphiphilic molecules within the individual lipid classes, while their composition depends on intrinsic and extrinsic factors. Recent developments in mass spectrometric methods have significantly contributed to the [...] Read more.
Lipids play many essential roles in living organisms, which accounts for the great diversity of these amphiphilic molecules within the individual lipid classes, while their composition depends on intrinsic and extrinsic factors. Recent developments in mass spectrometric methods have significantly contributed to the widespread application of the liquid chromatography-mass spectrometry (LC-MS) approach to the analysis of plant lipids. However, only a few investigators have studied the extensive composition of grape lipids. The present work describes the development of an ultrahigh performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method that includes 8098 MRM; the method has been validated using a reference sample of grapes at maturity with a successful analysis and semi-quantification of 412 compounds. The aforementioned method was subsequently applied also to the analysis of the lipid profile variation during the Ribolla Gialla cv. grape maturation process. The partial least squares (PLS) regression model fitted to our experimental data showed that a higher proportion of certain glycerophospholipids (i.e., glycerophosphoethanolamines, PE and glycerophosphoglycerols, PG) and of some hydrolysates from those groups (i.e., lyso-glycerophosphocholines, LPC and lyso-glycerophosphoethanolamines, LPE) can be positively associated with the increasing °Brix rate, while a negative association was found for ceramides (CER) and galactolipids digalactosyldiacylglycerols (DGDG). The validated method has proven to be robust and informative for profiling grape lipids, with the possibility of application to other studies and matrices. Full article
(This article belongs to the Special Issue Targeted Analysis and Quantification of Metabolites and Lipids in Plants, Mammals or Bioorganisms Using Metabolomics)
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18 pages, 4404 KiB  
Article
Preventing the Increase in Lysophosphatidic Acids: A New Therapeutic Target in Pulmonary Hypertension?
by Thomas Duflot, Ly Tu, Matthieu Leuillier, Hind Messaoudi, Déborah Groussard, Guillaume Feugray, Saïda Azhar, Raphaël Thuillet, Fabrice Bauer, Marc Humbert, Vincent Richard, Christophe Guignabert and Jérémy Bellien
Metabolites 2021, 11(11), 784; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo11110784 - 17 Nov 2021
Cited by 2 | Viewed by 2078
Abstract
Cardiovascular diseases (CVD) are the leading cause of premature death and disability in humans that are closely related to lipid metabolism and signaling. This study aimed to assess whether circulating lysophospholipids (LPL), lysophosphatidic acids (LPA) and monoacylglycerols (MAG) may be considered as potential [...] Read more.
Cardiovascular diseases (CVD) are the leading cause of premature death and disability in humans that are closely related to lipid metabolism and signaling. This study aimed to assess whether circulating lysophospholipids (LPL), lysophosphatidic acids (LPA) and monoacylglycerols (MAG) may be considered as potential therapeutic targets in CVD. For this objective, plasma levels of 22 compounds (13 LPL, 6 LPA and 3 MAG) were monitored by liquid chromatography coupled with tandem mass spectrometry (HPLC/MS2) in different rat models of CVD, i.e., angiotensin-II-induced hypertension (HTN), ischemic chronic heart failure (CHF) and sugen/hypoxia(SuHx)-induced pulmonary hypertension (PH). On one hand, there were modest changes on the monitored compounds in HTN (LPA 16:0, 18:1 and 20:4, LPC 16:1) and CHF (LPA 16:0, LPC 18:1 and LPE 16:0 and 18:0) models compared to control rats but these changes were no longer significant after multiple testing corrections. On the other hand, PH was associated with important changes in plasma LPA with a significant increase in LPA 16:0, 18:1, 18:2, 20:4 and 22:6 species. A deleterious impact of LPA was confirmed on cultured human pulmonary smooth muscle cells (PA-SMCs) with an increase in their proliferation. Finally, plasma level of LPA(16:0) was positively associated with the increase in pulmonary artery systolic pressure in patients with cardiac dysfunction. This study demonstrates that circulating LPA may contribute to the pathophysiology of PH. Additional experiments are needed to assess whether the modulation of LPA signaling in PH may be of interest. Full article
(This article belongs to the Special Issue Targeted Analysis and Quantification of Metabolites and Lipids in Plants, Mammals or Bioorganisms Using Metabolomics)
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