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Metabolites
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Urine Metabolome in Patients with Type 2 Diabetes
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Urine Metabolome in Patients with Type 2 Diabetes

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Endocrinology and Clinical Metabolic Research".

Deadline for manuscript submissions: closed (15 January 2023) | Viewed by 1743

Special Issue Editors

Dr. Eleni Bairaktari

E-Mail Website
Guest Editor
Laboratory of Clinical Chemistry, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece
Interests: metabolomics; NMR spectroscopy; biomarkers; renal function; lipoprotein analysis; diabetes mellitus
Dr. Aikaterini Dimou

E-Mail Website
Guest Editor
Laboratory of Clinical Chemistry, Faculty of Medicine, School of Health Sciences, University of Ioannina, 45110 Ioannina, Greece
Interests: metabolomics; NMR spectroscopy; biomarkers; BCAAs; liver disease; diabetes mellitus

Special Issue Information

Dear Colleagues,

Given its persistent worldwide prevalence, type 2 diabetes mellitus (T2D) and related microvascular and macrovascular complications have received considerable attention from the research community to improve our understanding of the underlying pathophysiological mechanisms.

Since the metabolic dysfunction associated with the development of diabetes begins decades before blood glucose increases, an ongoing challenge is the identification of better T2D prognostic biomarkers for individuals at risk for developing diabetes, especially in the absence of established risk factors. These biomarkers may be effective tools for the prognosis, screening, and diagnosis of diabetes, and may also highlight the pathways involved in T2D development.

Over the past decade, metabolomics based on high-throughput technologies have given us considerable insight into circulating in plasma biomarkers of T2D, whereas little is known about the role of the urine metabolome in the disease. The application of urine metabolic analysis to disease is an emerging field that shows great potential in biomarker discovery. It is abundant and readily available; can be collected by simple, noninvasive techniques; and allows for serial sampling to monitor disease and therapeutic response.

This Special Issue of Metabolites focuses on recent advances of urine metabolomics that are linked to the exploration of the metabolic dysfunction in T2D and contribute to the identification of reliable biomarkers.

Dr. Eleni Bairaktari
Dr. Aikaterini Dimou
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolomics urine
  • type 2 diabetes
  • metabolites
  • biomarkers
  • pre-analytical handling
  • analytical approaches
  • standardization

Published Papers (1 paper)

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Research

10 pages, 271 KiB  
Article
Assessment of Serum 25-Hydroxyvitamin D and Its Association in Type 2 Diabetes Mellitus Elderly Patients with Kidney Disease: A Retrospective Cross Sectional Study
by Moyad Shahwan, Nageeb Hassan, Noor Mazin, Ammar Jairoun, Sahab Al Khoja, Monzer Shahwan, Osama Najjar and Tariq Al-Qirim
Metabolites 2023, 13(3), 357; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo13030357 - 28 Feb 2023
Viewed by 1178
Abstract
The overall aim of this study is to determine the prevalence of vitamin D deficiency and its association with diabetic nephropathy in elderly patients with type 2 diabetes mellitus. This study is a single center retrospective cross-sectional design conducted at private medical center. [...] Read more.
The overall aim of this study is to determine the prevalence of vitamin D deficiency and its association with diabetic nephropathy in elderly patients with type 2 diabetes mellitus. This study is a single center retrospective cross-sectional design conducted at private medical center. The study group included all patients (18 years or older) suffering from type 2 diabetes mellitus that attended the diabetic clinic from September 2019 to January 2021. The main outcome variable is a trough level of (<20 ng/mL) for 25OHD. The patients were categorized as having diabetic nephropathy based on estimated glomerular filtration rate (eGFR). Total glycated hemoglobin (HbA1c), creatinine serum, Alb: Cr ratio, total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL-C), low-density lipoprotein (LDL-C), systolic blood pressure (SBP) and diastolic blood pressure (DBP) were compared between vitamin D deficiency groups. Univariate and multivariate logistic regression was used to investigate the association between vitamin D deficiency and other significant anthropometric and biochemical factors. A p value < 0.05 was chosen as the criterion to make decisions regarding statistical significance. Among the 453 diabetic patients included in study, 48.6% (n = 220) were male and 51.4% (n = 233) were female. The mean age ± S.D of the patients was 54.5 ± 10.6 years old. Out of 453 diabetic patients, 71.1% (95% CI: 66.9%–75.3%) had vitamin D deficiency (25OHD < 20 ng/mL). There was a statistically significant association between 25OHD level and diabetic nephropathy in elderly patients with type 2 diabetes mellitus. Diabetic patients with e-GFR < 60 mL/min more likely to have vitamin D deficiency (p < 0.001). Similarly, individuals with Alb: Cr ratio > 30 mg/g were more likely to have vitamin D deficiency (p < 0.001). Moreover, diabetic patients with serum creatinine > 1.8 mg/dL were more likely to have vitamin D deficiency (p < 0.001). The study revealed a high prevalence of vitamin D deficiency in elderly patients with type 2 diabetes mellitus. A significant association was reported between 25-hydroxyvitamin D, e-GFR and Alb: Cr ratio. Full article
(This article belongs to the Special Issue Urine Metabolome in Patients with Type 2 Diabetes)
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