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Metabolites
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Metabolomics in the Study of Veterinary Disease
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Metabolomics in the Study of Veterinary Disease

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Animal Metabolism".

Deadline for manuscript submissions: closed (21 July 2022) | Viewed by 10083

Special Issue Editor

Dr. Panos Loukopoulos

E-Mail Website
Guest Editor
Melbourne Veterinary School, Faculty of Veterinary and Agricultural Sciences, 3010 Melbourne, Australia
Interests: diagnostic pathology; metabolomics approaches; neoplasia; animal health

Special Issue Information

Dear Colleagues,

Despite their immense potential, omics technologies—particularly metabolomics—remain underutilised in the study of spontaneous (and to a smaller degree, experimental) animal disease. This Special Issue is designed to focus on studies employing omics approaches in the study of spontaneous and experimental animal disease, as promising tools regarding diagnosis and biomarker discovery, and in uncovering new insights into disease pathophysiology.

I would like to invite you to contribute your work to this Issue.

Dr. Panos Loukopoulos
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolomics
  • proteomics
  • omics
  • veterinary diseases
  • One Health
  • experimental disease

Published Papers (4 papers)

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Research

12 pages, 536 KiB  
Article
Changes in the Fatty Acid Composition of Milk of Lipizzaner Mares during the Lactation Period
by Maja Gregić, Pero Mijić, Mirjana Baban, Jasna Aladrović, Lana Pađen, Vesna Gantner and Tina Bobić
Metabolites 2022, 12(6), 506; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo12060506 - 31 May 2022
Cited by 3 | Viewed by 1354
Abstract
The composition and properties of the milk fat of mares’ milk is interesting from a nutritional standpoint. The aim of this study was to determine the nutritional value of Lipizzaner mare’s milk for possible human consumption and identity the influence of the parity [...] Read more.
The composition and properties of the milk fat of mares’ milk is interesting from a nutritional standpoint. The aim of this study was to determine the nutritional value of Lipizzaner mare’s milk for possible human consumption and identity the influence of the parity and stage of lactation on its fatty acid (FA) composition. This study was conducted on 17 Lipizzaner mares from a state stud farm in the Slavonian region (eastern Croatia). Mares were hand-milked twice during lactation in the fourth and sixth months. Significantly higher contents of MUFAs (monounsaturated fatty acids) and PUFAs (polyunsaturated fatty acids) and lower ratios of n-6/n-3 were found in the fourth month of lactation. This parity significantly affected the PUFA/SFA ratio (polyunsaturated fatty acids/saturated fatty acids), with lower values found in older mares. The fatty acid composition of mare’s milk that is especially high in UFAs (unsaturated fatty acids) is considered to be beneficial for consumers. Full article
(This article belongs to the Special Issue Metabolomics in the Study of Veterinary Disease)
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16 pages, 2790 KiB  
Article
Metabolic Responses of Dietary Fiber during Heat Stress: Effects on Reproductive Performance and Stress Level of Gestating Sows
by SeungMin Oh, Abdolreza Hosseindoust, SangHun Ha, Joseph Moturi, JunYoung Mun, Habeeb Tajudeen and JinSoo Kim
Metabolites 2022, 12(4), 280; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo12040280 - 23 Mar 2022
Cited by 8 | Viewed by 2527
Abstract
Heat stress is an important issue, and the addition of fiber to the diet is an option in modifying intestinal health. This study evaluated the effect of acid detergent fiber (ADF) levels on reproductive performance, intestinal integrity, and metabolism of gestating sows, and [...] Read more.
Heat stress is an important issue, and the addition of fiber to the diet is an option in modifying intestinal health. This study evaluated the effect of acid detergent fiber (ADF) levels on reproductive performance, intestinal integrity, and metabolism of gestating sows, and its carry-over effect on the lactation period during heat stress. The diets included 4.3% (Low fiber; LF), 5.4% (Medium fiber; MF), and 6.5% (High fiber; HF) ADF. Sows fed the HF diet showed a lower respiratory rate, hair cortisol concentration, and farrowing duration compared with the LF treatment. The HF diet increased the pyruvate, citrate cycle, glyoxylate, dicarboxylate, and thiamine metabolism compared with the MF. The concentration of acetate and total short-chain fatty acids were increased in the sows fed the HF diet. The gene expression of glucose transporter 3 and glucose transporter 4 was increased in the HF treatment. The gene expression of heat shock protein 70 was decreased in the HF treatment. The HF diet during gestation increased feed intake, constipation index, piglet weight, and litter weight compared with the LF. Sows in the LF treatment showed the greatest digestibility of crude protein and the lowest digestibility of ADF. In conclusion, a 6.5% ADF level is recommended for gestating sows during heat stress. Full article
(This article belongs to the Special Issue Metabolomics in the Study of Veterinary Disease)
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16 pages, 3021 KiB  
Article
A Preliminary Metabolomic Study of Yorkshire Terrier Enteropathy
by Alexandra I. Galler, Kristaps Klavins and Iwan A. Burgener
Metabolites 2022, 12(3), 264; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo12030264 - 19 Mar 2022
Cited by 4 | Viewed by 2392
Abstract
Perturbations of metabolite profiles in human and canine enteropathies have been reported before. However, data in dogs are scarce and inconsistent. Currently, the metabolite profile in Yorkshire Terrier enteropathy (YTE) and the impact of treatment is unknown. The objective of this study was [...] Read more.
Perturbations of metabolite profiles in human and canine enteropathies have been reported before. However, data in dogs are scarce and inconsistent. Currently, the metabolite profile in Yorkshire Terrier enteropathy (YTE) and the impact of treatment is unknown. The objective of this study was to investigate the plasma metabolome of 13 Yorkshire Terriers with YTE and compare it to 20 healthy Yorkshire Terriers. Furthermore, we studied the impact of treatment on the metabolome. In this prospective observational study, plasma metabolite profiles were analyzed by flow injection analysis-tandem mass spectrometry (FIA-MS/MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) using a targeted metabolomics kit. Metabolite analysis revealed that YTE is accompanied by changes in lipid and bile acid metabolism. YTE was associated with a significant decrease of long-chain fatty acids (octadecenoic acid, eicosadienoic acid, eicosatrienoic acid) and lower levels of long-chain acylcarnitines (tetradecanoylcarnitine, hexadecanoylcarnitine, hexadecenoylcarnitine, octadecenoylcarnitine) compared with healthy controls. Furthermore, taurodeoxycholic acid, a secondary bile acid, was decreased in plasma from YTE patients. These changes might be breed-specific and might be involved in the pathogenesis of YTE. Interestingly, changes in metabolite levels were not recovered after treatment and differed considerably from healthy controls. Full article
(This article belongs to the Special Issue Metabolomics in the Study of Veterinary Disease)
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21 pages, 2570 KiB  
Article
Untargeted Metabolomics Identify a Panel of Urinary Biomarkers for the Diagnosis of Urothelial Carcinoma of the Bladder, as Compared to Urolithiasis with or without Urinary Tract Infection in Dogs
by Maria Malvina Tsamouri, Blythe P. Durbin-Johnson, William T. N. Culp, Carrie A. Palm, Mamta Parikh, Michael S. Kent and Paramita M. Ghosh
Metabolites 2022, 12(3), 200; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo12030200 - 24 Feb 2022
Cited by 2 | Viewed by 2753
Abstract
Urothelial carcinoma (UC), the most common urologic cancer in dogs, is often diagnosed late because the clinical signs are shared by other non-malignant lower urinary tract disorders (LUTD). The urine-based BRAFV595E test for UC is highly effective only in certain breeds; hence [...] Read more.
Urothelial carcinoma (UC), the most common urologic cancer in dogs, is often diagnosed late because the clinical signs are shared by other non-malignant lower urinary tract disorders (LUTD). The urine-based BRAFV595E test for UC is highly effective only in certain breeds; hence additional non-invasive biomarkers of UC are needed. Here, urine from dogs with UC (n = 27), urolithiasis (n = 8), or urolithiasis with urinary tract infection (UTI) (n = 8) were subjected to untargeted metabolomics analyses, using GC-TOF-MS for primary metabolites, QTOF-MS for complex lipids, and HILIC-QTOF MS for secondary and charged metabolites. After adjusting for age and sex, we identified 1123 known metabolites that were differentially expressed between UC and LUTD. Twenty-seven metabolites were significant (1.5 ≤ log2FC ≤ −1.5, adjusted p-value < 0.05); however, 10 of these could be attributed to treatment-related changes. Of the remaining 17, 6 (hippuric acid, N-Acetylphenylalanine, sarcosine, octanoylcarnitine, N-alpha-methylhistamine, glycerol-3-galactoside) discriminated between UC and LUTD (area under the ROC curve > 0.85). Of the 6 metabolites, only hippuric acid and N-alpha-methylhistamine were discriminatory in both male (n = 20) and female (n = 23) dogs, while sarcosine was an effective discriminator in several breeds, but only in females. Further investigation of these metabolites is warranted for potential use as non-invasive diagnostic biomarkers of dogs with UC that present with LUTD-related clinical signs. Full article
(This article belongs to the Special Issue Metabolomics in the Study of Veterinary Disease)
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