Metabolomics in Precision Medicine

A special issue of Metabolites (ISSN 2218-1989). This special issue belongs to the section "Advances in Metabolomics".

Deadline for manuscript submissions: closed (31 January 2020) | Viewed by 3004

Special Issue Editor


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Guest Editor
FNRS Research Director, CIRM, Metabolomics group, Université de Liège, Quartier Hôpital, Avenue Hippocrate 15, B-4000 Liège, Belgium
Interests: NMR-based metabolomics; translational research; personalized medicine; drug and target discovery

Special Issue Information

Dear Colleagues,

During the last decade, patient care and treatments have continuously evolved to a more personalized approach, focusing on the medical care of the patient, which probably represents the most promising paradigm change in modern medicine. Personalized or precision medicine is a key issue at present and will probably be a key determinant factor for the future of treatment and drug development. Such an approach requires an improved knowledge of patients (genotype, phenotype, lifestyle), pathology status (grade, evolution), and treatment (dose, timing, repetition). Because it provides unique insights into the relationships between physiological status, lifestyle, pathologies, and patients, and because it correlates with a patient’s disease phenotype, metabolomics is particularly adapted to obtain relevant and helpful information for a personalized approach to treatment. Moreover, metabolomics is also particularly adapted to study the impact of the exposome on the population, which can lead to essential information about pathology development.

The topics that will be covered by this Special Issue include: the application of metabolomics in personalized or precision medicine, metabolomics in diagnosis, treatment follow-up and patient stratification using metabolomics, metabolomics in clinics, the use of metabolomics in the drug discovery process, and methodological development for data integration (omics and non-omics data) in personalized models.

Dr. Pascal de Tullio
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Metabolites is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metabolomics
  • personalized medicine
  • precision medicine
  • diagnosis and treatment

Published Papers (1 paper)

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Review

13 pages, 586 KiB  
Review
Using Cerebral Metabolites to Guide Precision Medicine for Subarachnoid Hemorrhage: Lactate and Pyruvate
by Kaneez Zahra, Neethu Gopal, William D. Freeman and Marion T. Turnbull
Metabolites 2019, 9(11), 245; https://0-doi-org.brum.beds.ac.uk/10.3390/metabo9110245 - 23 Oct 2019
Cited by 8 | Viewed by 2709
Abstract
Subarachnoid hemorrhage (SAH) is one of the deadliest types of strokes with high rates of morbidity and permanent injury. Fluctuations in the levels of cerebral metabolites following SAH can be indicators of brain injury severity. Specifically, the changes in the levels of key [...] Read more.
Subarachnoid hemorrhage (SAH) is one of the deadliest types of strokes with high rates of morbidity and permanent injury. Fluctuations in the levels of cerebral metabolites following SAH can be indicators of brain injury severity. Specifically, the changes in the levels of key metabolites involved in cellular metabolism, lactate and pyruvate, can be used as a biomarker for patient prognosis and tailor treatment to an individual’s needs. Here, clinical research is reviewed on the usefulness of cerebral lactate and pyruvate measurements as a predictive tool for SAH outcomes and their potential to guide a precision medicine approach to treatment. Full article
(This article belongs to the Special Issue Metabolomics in Precision Medicine)
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