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Selected Papers from the 3rd Iberoamerican Symposium on Organic Chemistry (SIBEAQO-3)

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A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (30 November 2016) | Viewed by 19039

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Special Issue Editor

Prof. Dr. Artur M. S. Silva

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Guest Editor

LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
Interests: organic chemistry; green synthetic organic chemistry; synthesis of heterocyclic compounds; natural products; NMR techniques; synthesis of new compounds with biocidal and antioxidant activities
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Special Issue Information

Dear Colleagues,

The 3^rd Iberoamerican Symposium on Organic Chemistry (3º Simpósio Iberoamericano de Química Orgânica), (SIBEAQO-3), will be held at the Auditorium Professor Ferreira da Silva, Department of Computers Sciences, Faculty of Sciences, University of Porto (FCUP), from 23 to 26 September, 2016.

The main objective of this symposium is to create a scientific framework in the field of Organic Chemistry and related fields, to promote the exchange of ideas and experiences, collaboration and mobility among researchers from Latin America, Portugal and Spain. This meeting comes after two previous symposiums, the SIBEAQO-I, held in Mar del Plata (Argentina) in November 2007, attended by 150 participants, and SIBEAQO-II, held in Santiago de Compostela in September 2010, with 200 participants.

The SIBEAQO-3 scientific program includes excellent speakers, as nine plenary lectures, nine invited lectures, fourteen oral communications, and a high number of poster communications, are scheduled. For all details, please see http://www.iceta.up.pt/SIBEAQO3/conferencia_en.html, where the full list of speakers is available, including as plenary speakers, Dean Toste (Univ. California, Berkeley, USA), Luis Echegoyen (Univ. Texas, USA), Eusebio Juaristi (CINVESTAV-IPN, MEXICO), Jesús Jimenez Barbero (CIC bioGUNE, SPAIN), Ronaldo A. Pilli (UNICAMP, BRAZIL), João F. Mano (Univ. Minho, PORTUGAL), Augusto Costa Tomé (Univ. Aveiro, PORTUGAL), Carlos Afonso (Univ. Lisboa, PORTUGAL), and José Barluenga Mur (Univ. Oviedo, SPAIN).

Participants of the conference are cordially invited to contribute original research papers or reviews to this Special Issue of Molecules.

Prof. Dr. Artur Silva
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

chemistry organometallic
organocatalysis
synthesis
supramolecular and biological chemistry
nano and new materials
natural and medical chemistry products
green chemistry
theoretical chemistry - applications
chemistry in education and society

Published Papers (3 papers)

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1345 KiB

Open AccessArticle

Oxidation of 5-Chloromethylfurfural (CMF) to 2,5-Diformylfuran (DFF)

by Ana I. Vicente, Jaime A. S. Coelho, Svilen P. Simeonov, Hristina I. Lazarova, Margarita D. Popova and Carlos A. M. Afonso

Molecules 2017, 22(2), 329; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules22020329 - 20 Feb 2017

Cited by 11 | Viewed by 7219

Abstract

2,5-Diformylfuran (DFF) is an important biorenewable building block, namely for the manufacture of new polymers that may replace existing materials derived from limited fossil fuel resources. The current reported methods for the preparation of DFF are mainly derived from the oxidation of 5-hydroxymethylfurfural (HMF) and, to a lesser extent, directly from fructose. 5-Chloromethylfurfural (CMF) has been considered an alternative to HMF as an intermediate building block due to its advantages regarding stability, polarity, and availability from glucose and cellulose. The only reported method for the transformation of CMF to DFF is restricted to the use of DMSO as the solvent and oxidant. We envisioned that the transformation could be performed using more attractive conditions. To that end, we explored the oxidation of CMF to DFF by screening several oxidants such as H₂O₂, oxone, and pyridine N-oxide (PNO); different heating methods, namely thermal and microwave irradiation (MWI); and also flow conditions. The combination of PNO (4 equiv.) and Cu(OTf)₂ (0.5 equiv.) in acetonitrile was identified as the best system, which lead to the formation of DFF in 54% yield under MWI for 5 min at 160 °C. Consequently, a range of different heterogeneous copper catalysts were tested, which allowed for catalyst reuse. Similar results were also observed under flow conditions using copper immobilized on silica under thermal heating at 160 °C for a residence time of 2.7 min. Finally, HMF and 5,5′-oxybis(5-methylene-2-furaldehyde) (OBMF) were the only byproducts identified under the reaction conditions studied. Full article

(This article belongs to the Special Issue Selected Papers from the 3rd Iberoamerican Symposium on Organic Chemistry (SIBEAQO-3))

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1288 KiB

Open AccessArticle

Antiparasitic Activity of Sulfur- and Fluorine-Containing Bisphosphonates against Trypanosomatids and Apicomplexan Parasites

by Tamila Galaka, Mariana Ferrer Casal, Melissa Storey, Catherine Li, María N. Chao, Sergio H. Szajnman, Roberto Docampo, Silvia N. J. Moreno and Juan B. Rodriguez

Molecules 2017, 22(1), 82; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules22010082 - 04 Jan 2017

Cited by 11 | Viewed by 6211

Abstract

Based on crystallographic data of the complexes 2-alkyl(amino)ethyl-1,1-bisphosphonates–Trypanosoma cruzi farnesyl diphosphate synthase, some linear 1,1-bisphosphonic acids and other closely related derivatives were designed, synthesized and biologically evaluated against T. cruzi, the responsible agent of Chagas disease and against Toxoplasma gondii, the etiologic agent of toxoplasmosis and also towards the target enzymes farnesyl pyrophosphate synthase of T. cruzi (TcFPPS) and T gondii (TgFPPS), respectively. The isoprenoid-containing 1,1-bisphosphonates exhibited modest antiparasitic activity, whereas the linear α-fluoro-2-alkyl(amino)ethyl-1,1-bisphosphonates were unexpectedly devoid of antiparasitic activity. In spite of not presenting efficient antiparasitic activity, these data turned out to be very important to establish a structural activity relationship. Full article

(This article belongs to the Special Issue Selected Papers from the 3rd Iberoamerican Symposium on Organic Chemistry (SIBEAQO-3))

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4707 KiB

Open AccessConference Report

Multifunctional Nanomaterials: Design, Synthesis and Application Properties

by Marisa Martinelli and Miriam Cristina Strumia

Molecules 2017, 22(2), 243; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules22020243 - 07 Feb 2017

Cited by 11 | Viewed by 4872

Abstract

The immense scope of variation in dendritic molecules (hyper-branching, nano-sized, hydrophobicity/hydrophilicity, rigidity/flexibility balance, etc.) and their versatile functionalization, with the possibility of multivalent binding, permit the design of highly improved, novel materials. Dendritic-based materials are therefore viable alternatives to conventional polymers. The overall aim of this work is to show the advantages of dendronization processes by presenting the synthesis and characterization of three different dendronized systems: (I) microbeads of functionalized chitosan; (II) nanostructuration of polypropylene surfaces; and (III) smart dendritic nanogels. The particular properties yielded by these systems could only be achieved thanks to the dendronization process. Full article

(This article belongs to the Special Issue Selected Papers from the 3rd Iberoamerican Symposium on Organic Chemistry (SIBEAQO-3))

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