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Marine Drugs
Special Issues
Seaweed Bioactive Metabolites: Health Benefits and Potential Applications 2nd Edition
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Seaweed Bioactive Metabolites: Health Benefits and Potential Applications 2nd Edition

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Biotechnology Related to Drug Discovery or Production".

Deadline for manuscript submissions: closed (26 January 2024) | Viewed by 9133

Special Issue Editors

Dr. Susana M. Cardoso

E-Mail Website
Guest Editor
LAQV-REQUIMTE, Department of Chemistry, Universidade de Aveiro, 3810-193 Aveiro, Portugal
Interests: natural products; structural analysis; nutrients and bioactive compounds; liquid chromatography; mass spectrometry; antioxidant; bioactivity; bioaccessibility and bioavailability; added-value products
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Artur M. S. Silva

E-Mail Website
Guest Editor
LAQV-REQUIMTE, Department of Chemistry, University of Aveiro, 3810-193 Aveiro, Portugal
Interests: organic chemistry; green synthetic organic chemistry; synthesis of heterocyclic compounds; natural products; NMR techniques; synthesis of new compounds with biocidal and antioxidant activities
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Motivated by the success of the previous Special Issue “Seaweed Bioactive Metabolites: Health Benefits and Potential Applications” (https://0-www-mdpi-com.brum.beds.ac.uk/journal/marinedrugs/special_issues/seaweed_bioactive_metabolites) in the journal Marine Drugs, I have decided to pursue a follow-up Special Issue, "Seaweed Bioactive Metabolites: Health Benefits and Potential Applications 2nd Edition".

Seaweeds or macroalgae are potential renewable resources in the marine ecosystem and are recognized as a great source of health-promoting metabolites such as polyphenols, terpenoids, alkaloids, steroids, pigments, polysaccharides, fatty acids, and peptides, some of which are not even found in terrestrial plants. These facts, along with the growing consumer demand for natural ingredients without adverse effects, have boosted the research devoted to macroalgae in recent decades, to potentiate their commercial exploitation in the medical, pharmaceutical, nutraceutical, food, agricultural, and cosmetic industries.

Contributions to this Special Issue, both in the form of original research and review articles, may cover distinct aspects related to seaweed bioactive metabolites, including, but not limited to, their extraction and purification; structural characterization of new compounds; biological activities and mechanisms of actions of extracts, purified fractions, isolated compounds, and/or of novel value-added products; structure–bioactive relations; interaction with other substances in the formulated matrices; and the safety and stability of new value-added products.

Dr. Susana M. Cardoso
Prof. Dr. Artur M. S. Silva
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Marine Drugs is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • primary and secondary metabolites
  • bioactive properties
  • technological applications
  • isolation of bioactive compounds
  • value-added products

Published Papers (4 papers)

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Research

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13 pages, 2392 KiB  
Article
Production of Ethyl-agarobioside, a Novel Skin Moisturizer, by Mimicking the Alcoholysis from the Japanese Sake-Brewing Process
by Sun-Hee Lee, Eun Ju Yun, Na Ree Han, Inho Jung, Jeffrey G. Pelton, Jae-Eun Lee, Nam Joo Kang, Yong-Su Jin and Kyoung Heon Kim
Mar. Drugs 2023, 21(6), 341; https://0-doi-org.brum.beds.ac.uk/10.3390/md21060341 - 01 Jun 2023
Cited by 1 | Viewed by 1377
Abstract
Agarobiose (AB; d-galactose-β-1,4-AHG), produced by one-step acid hydrolysis of agarose of red seaweed, is considered a promising cosmetic ingredient due to its skin-moisturizing activity. In this study, the use of AB as a cosmetic ingredient was found to be hampered due to [...] Read more.
Agarobiose (AB; d-galactose-β-1,4-AHG), produced by one-step acid hydrolysis of agarose of red seaweed, is considered a promising cosmetic ingredient due to its skin-moisturizing activity. In this study, the use of AB as a cosmetic ingredient was found to be hampered due to its instability at high temperature and alkaline pH. Therefore, to increase the chemical stability of AB, we devised a novel process to synthesize ethyl-agarobioside (ethyl-AB) from the acid-catalyzed alcoholysis of agarose. This process mimics the generation of ethyl α-glucoside and glyceryl α-glucoside by alcoholysis in the presence of ethanol and glycerol during the traditional Japanese sake-brewing process. Ethyl-AB also showed in vitro skin-moisturizing activity similar to that of AB, but showed higher thermal and pH stability than AB. This is the first report of ethyl-AB, a novel compound produced from red seaweed, as a functional cosmetic ingredient with high chemical stability. Full article
(This article belongs to the Special Issue Seaweed Bioactive Metabolites: Health Benefits and Potential Applications 2nd Edition)
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13 pages, 4554 KiB  
Article
Influence of Intestinal Barrier on Alleviating an Increase in Blood Pressure by Sodium Alginate Intake in 2-Kidney, 1-Clip Renovascular Hypertensive Rats
by Saki Maruyama, Yukiko Segawa, Ayaka Harui, Kanae Yamamoto, Hiroko Hashimoto, Tomoko Osera and Nobutaka Kurihara
Mar. Drugs 2023, 21(6), 324; https://0-doi-org.brum.beds.ac.uk/10.3390/md21060324 - 26 May 2023
Cited by 1 | Viewed by 1757
Abstract
Sodium alginate (SALG) is a substance derived from brown seaweed that has been shown to reduce blood pressure (BP). However, its effects on renovascular hypertension caused by 2-kidney, 1-clip (2K1C) are not yet clear. Previous research suggests that hypertensive rats have increased intestinal [...] Read more.
Sodium alginate (SALG) is a substance derived from brown seaweed that has been shown to reduce blood pressure (BP). However, its effects on renovascular hypertension caused by 2-kidney, 1-clip (2K1C) are not yet clear. Previous research suggests that hypertensive rats have increased intestinal permeability, and that SALG improves the gut barrier in inflammatory bowel disease mouse models. Therefore, the goal of this study was to determine whether the antihypertensive effects of SALG involve the intestinal barrier in 2K1C rats. Rats were fed either a 1.0% SALG diet or a control diet for six weeks after being subjected to 2K1C surgery or a sham operation. The systolic BP was measured weekly, and the mean arterial BP was measured at the end of the study. Intestinal samples were taken for analysis, and plasma lipopolysaccharide (LPS) levels were measured. The results showed that BP in 2K1C rats was significantly higher than in SHAM rats when fed CTL, but not when fed SALG. The gut barrier in 2K1C rats was improved by SALG intake. Plasma LPS levels also differed depending on the animal model and diet. In conclusion, dietary SALG may alleviate 2K1C renovascular hypertension by altering the gut barrier. Full article
(This article belongs to the Special Issue Seaweed Bioactive Metabolites: Health Benefits and Potential Applications 2nd Edition)
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23 pages, 3346 KiB  
Article
Evaluation of Phytochemical Screening, Pigment Content, In Vitro Antioxidant, Antibacterial Potential and GC-MS Metabolite Profiling of Green Seaweed Caulerpa racemosa
by Sivagaami Palaniyappan, Arun Sridhar, Zulhisyam Abdul Kari, Guillermo Téllez-Isaías and Thirumurugan Ramasamy
Mar. Drugs 2023, 21(5), 278; https://0-doi-org.brum.beds.ac.uk/10.3390/md21050278 - 28 Apr 2023
Cited by 3 | Viewed by 3281
Abstract
Exploration of seaweeds to unravel their bioactive metabolites from the perspective of wider applications gained substantial importance. The present study was performed to investigate the total phenolic, flavonoid, tannin content, antioxidant activity and antibacterial potential of various solvent extracts of green seaweed Caulerpa [...] Read more.
Exploration of seaweeds to unravel their bioactive metabolites from the perspective of wider applications gained substantial importance. The present study was performed to investigate the total phenolic, flavonoid, tannin content, antioxidant activity and antibacterial potential of various solvent extracts of green seaweed Caulerpa racemosa. The methanolic extract showed higher phenolic (11.99 ± 0.48 mg gallic acid equivalents/g), tannin (18.59 ± 0.54 mg tannic acid equivalents/g) and flavonoid (33.17 ± 0.76 mg quercetin equivalents/g) content than other extracts. Antioxidant activity was determined by using 2,2-diphenylpicrylhydrazyl (DPPH) and 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay with different concentrations of C. racemosa extracts. The methanolic extract showed higher scavenging potential in both the DPPH and ABTS activity with the inhibition value of 54.21 ± 1.39% and 76.62 ± 1.08%, respectively. Bioactive profiling was also identified by using Gas chromatography-mass spectrometry (GC-MS) and Fourier transform infrared (FT-IR) techniques. These studies revealed the presence of valuable bioactive compounds in C. racemosa extracts and these compounds might be responsible for antimicrobial, antioxidant, anticancer and anti-mutagenic properties. Major compounds identified in GC-MS were 3,7,11,15-Tetramethyl-2-hexadecen-1-ol, 3-hexadecene and Phthalic acid. In terms of antibacterial activity, C. racemosa has promising antibacterial potential against aquatic pathogens Aeromonas hydrophila, Aeromonas veronii and Aeromonas salmonicida. Further evaluation studies focusing aquatic related aspects would reveal the novel bioproperties and applications of C. racemosa. Full article
(This article belongs to the Special Issue Seaweed Bioactive Metabolites: Health Benefits and Potential Applications 2nd Edition)
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Review

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29 pages, 3607 KiB  
Review
An Update on the Chemical Constituents and Biological Properties of Selected Species of an Underpinned Genus of Red Algae: Chondrus
by Seon-Joo Park, Anshul Sharma and Hae-Jeung Lee
Mar. Drugs 2024, 22(1), 47; https://0-doi-org.brum.beds.ac.uk/10.3390/md22010047 - 17 Jan 2024
Viewed by 2092
Abstract
Macroalgae, particularly red seaweeds, have attracted significant attention due to their economic and health benefits. Chondrus, a red algae genus, despite its economic importance, seems to be undervalued. Among all its species, Chondrus crispus has been meticulously documented for its biological properties, [...] Read more.
Macroalgae, particularly red seaweeds, have attracted significant attention due to their economic and health benefits. Chondrus, a red algae genus, despite its economic importance, seems to be undervalued. Among all its species, Chondrus crispus has been meticulously documented for its biological properties, and little is known about other species. No comprehensive review of the biological properties of this genus has been acknowledged. Thus, this review aimed to summarize the available information on the chemical constituents and biological properties of a few selected species, including Chondrus crispus, Chondrus ocellatus, Mazzaella canaliculata, and Chondrus armatus. We compiled and discovered that the genus is offering most of the important health-promoting benefits evidenced from in vitro and in vivo studies focused on antimicrobial, immunomodulation, neuroprotection, anti-atopic, anti-inflammatory, anti-viral, anti-diabetic, cytoprotective, antioxidant, anti-coagulation, nephroprotective, anti-tumor, and anti-venom activity, which speaks about the potential of this genus. Data on clinical studies are limited. Further, around 105 chemical constituents have been reported from Chondrus spp. Given its significance, further investigation is warranted, in the form of meticulously planned cell, animal, and clinical studies that concentrate on novel health-enhancing endeavors, in order to unveil the full potential of this genus. The review also outlines challenges and future directions. Full article
(This article belongs to the Special Issue Seaweed Bioactive Metabolites: Health Benefits and Potential Applications 2nd Edition)
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