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Molecules
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Biomolecular Self-Assemblies
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Biomolecular Self-Assemblies

A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".

Deadline for manuscript submissions: closed (30 January 2020) | Viewed by 7269

Special Issue Editor

Dr. Sébastien Ulrich

E-Mail Website
Guest Editor
IBMM, Université de Montpellier, CNRS, ENSCM, Montpellier, France
Interests: self-assembly; self-assembled multivalency; supramolecular chemistry; dynamic covalent/combinatorial chemistry; gene delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Over the past few decades, supramolecular chemistry has yielded fascinating and unprecedented structures. Recent years have seen major breakthroughs at the interface of supramolecular chemistry and biological sciences. Novel biomimetic and bioinspired nanoarchitectures that incorporate biomolecules have been generated by programmed or templated self-assembly processes using supramolecular interactions or dynamic covalent reactions. Application studies in biorecognition, DNA/RNA recognition, biosensing, enzyme inhibition, and drug/gene/protein delivery have then revealed the unique and attractive behaviors of such dynamic and adaptive self-assemblies. This Special Issue of Molecules will be devoted to showcasing these tremendous progresses that push the boundary of the bio-supramolecular interface and open new and exciting avenues for the design, production, and application of biomolecular self-assemblies.

Dr. Sébastien Ulrich
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Self-assembly
  • Supramolecular chemistry
  • Dynamic covalent/combinatorial chemistry
  • Metallo-supramolecules
  • Bioconjugates
  • Peptide self-assembly
  • Carbohydrate clusters
  • DNA-templated self-assembly
  • Multivalency

Published Papers (1 paper)

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Review

27 pages, 7830 KiB  
Review
Pharmaceutical Applications of Molecular Tweezers, Clefts and Clips
by Amira Mbarek, Ghina Moussa and Jeanne Leblond Chain
Molecules 2019, 24(9), 1803; https://0-doi-org.brum.beds.ac.uk/10.3390/molecules24091803 - 09 May 2019
Cited by 30 | Viewed by 6910
Abstract
Synthetic acyclic receptors, composed of two arms connected with a spacer enabling molecular recognition, have been intensively explored in host-guest chemistry in the past decades. They fall into the categories of molecular tweezers, clefts and clips, depending on the geometry allowing the recognition [...] Read more.
Synthetic acyclic receptors, composed of two arms connected with a spacer enabling molecular recognition, have been intensively explored in host-guest chemistry in the past decades. They fall into the categories of molecular tweezers, clefts and clips, depending on the geometry allowing the recognition of various guests. The advances in synthesis and mechanistic studies have pushed them forward to pharmaceutical applications, such as neurodegenerative disorders, infectious diseases, cancer, cardiovascular disease, diabetes, etc. In this review, we provide a summary of the synthetic molecular tweezers, clefts and clips that have been reported for pharmaceutical applications. Their structures, mechanism of action as well as in vitro and in vivo results are described. Such receptors were found to selectively bind biological guests, namely, nucleic acids, sugars, amino acids and proteins enabling their use as biosensors or therapeutics. Particularly interesting are dynamic molecular tweezers which are capable of controlled motion in response to an external stimulus. They proved their utility as imaging agents or in the design of controlled release systems. Despite some issues, such as stability, cytotoxicity or biocompatibility that still need to be addressed, it is obvious that molecular tweezers, clefts and clips are promising candidates for several incurable diseases as therapeutic agents, diagnostic or delivery tools. Full article
(This article belongs to the Special Issue Biomolecular Self-Assemblies)
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