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Nanomaterials
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Recent Advances in the Construction and Applications of Nanozymes
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Recent Advances in the Construction and Applications of Nanozymes

A special issue of Nanomaterials (ISSN 2079-4991). This special issue belongs to the section "Biology and Medicines".

Deadline for manuscript submissions: closed (31 October 2023) | Viewed by 7241

Special Issue Editors

Dr. Prakash Kshirsagar

E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Durham Research Center I, Room 7005, Omaha, NE 68198-5870, USA
Interests: biomaterials; metal nanoparticles; functional nanoenzymes; cancer treatment; cancer nanomedicine; nano-biointerface; cancer diagnosis; nanovaccine
Dr. Valeria De Matteis

E-Mail Website
Guest Editor
Nanobiotechnology, Nanomedicine, and Nanobioelectronics Laboratory, Department of Mathematics and Physics “Ennio De Giorgi”, University of Salento, via per Arnesano 16, 73100 Lecce, Italy
Interests: physics applied to biology; nanomaterials and toxicity; green nanomaterials; biophysics of cell membranes; biomaterials; silver and gold nanoparticles
Special Issues, Collections and Topics in MDPI journals
Dr. Sudipto Pal

E-Mail Website
Guest Editor
Department of Engineering for Innovation, University of Salento, 73100 Lecce, Italy
Interests: metal nanoparticles; photocatalysis functional coatings; antibacterial surfaces; sustainable engineering

Special Issue Information

Dear Colleagues,

Biological enzymes are macromolecular-sized catalysts that catalyze biochemical reactions. Although each enzyme performs a particular function, it holds several drawbacks, limiting its utilization in broad-spectrum applications. Therefore, as an alternative, several synthetic strategies have been introduced to formulate novel types of enzymes that can mimic intrinsic enzymatic properties and overcome the limitations of natural enzymes. The new generation of nanoparticle-based artificial enzymes (nanoenzymes) has gained recognition as surrogates for natural enzymes owing to their physicochemical attributes and advantages, including low-cost and straightforward synthesis methods, high stability, robust catalytic performance, and ease of surface modification. Seeing these advantages of nanozymes, a rapid expansion of the development of artificial biocatalysts is much needed. However, nanozymes have already found multidisciplinary applications in a wide range of applications in biosensing, immunoassays, disease diagnosis and therapy, theranostics, cell/tissue growth, protection from oxidative stress, and removal of pollutants. This Special Issue will comprehensively highlight the scientific and commercial value of nanozymes, mainly in the field of cancer diagnosis, imaging, and treatments, as well as the study of the enzyme-like properties (such as peroxidase, catalase, superoxide dismutase, and oxidase), exhibited by various metal nanoparticles. We cordially invite authors to contribute either research articles or reviews, or short communication to this emerging area of nanozymes.

Special Issue Research areas may include (but are not limited to) the following areas.

  • Synthetic strategies and applications of various enzyme-mimicking nanomaterials.
  • Precise tailoring of the enzymatic activities of nanozymes.
  • Mechanistic insights of nanozymes.
  • Study of nanoenzyme properties.
  • Peroxidase, catalase, superoxide dismutase, and oxidase.
  • Nanozyme applications for cancer diagnostics, therapeutics, and theranostics.

We are looking forward to receiving your contributions.

Dr. Prakash Kshirsagar
Dr. Valeria De Matteis
Dr. Sudipto Pal
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nanomaterials is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • metal nanoparticle
  • nanozyme
  • enzyme-mimic nanoparticles
  • enzymatic catalysis
  • peroxidase, catalase, oxidase
  • cancer
  • diagnosis
  • imaging
  • therapy

Published Papers (3 papers)

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17 pages, 3507 KiB  
Article
Silver–Gold Alloy Nanoparticles (AgAu NPs): Photochemical Synthesis of Novel Biocompatible, Bimetallic Alloy Nanoparticles and Study of Their In Vitro Peroxidase Nanozyme Activity
by Prakash G. Kshirsagar, Valeria De Matteis, Sudipto Pal and Shiv Shankar Sangaru
Nanomaterials 2023, 13(17), 2471; https://0-doi-org.brum.beds.ac.uk/10.3390/nano13172471 - 01 Sep 2023
Viewed by 1169
Abstract
Facile synthesis of metal nanoparticles with controlled physicochemical properties using environment-friendly reagents can open new avenues in biomedical applications. Nanomaterials with controlled physicochemical properties have opened new prospects for a variety of applications. In the present study, we report a single-step photochemical synthesis [...] Read more.
Facile synthesis of metal nanoparticles with controlled physicochemical properties using environment-friendly reagents can open new avenues in biomedical applications. Nanomaterials with controlled physicochemical properties have opened new prospects for a variety of applications. In the present study, we report a single-step photochemical synthesis of ~5 nm-sized silver (Ag) and gold (Au) nanoparticles (NPs), and Ag–Au alloy nanoparticles using L-tyrosine. The physicochemical and surface properties of both monometallic and bimetallic NPs were investigated by analytical, spectroscopic, and microscopic techniques. Our results also displayed an interaction between L-tyrosine and surface atoms that leads to the formation of AgAu NPs by preventing the growth and aggregation of the NPs. This method efficiently produced monodispersed NPs, with a narrow-sized distribution and good stability in an aqueous solution. The cytotoxicity assessment performed on breast cancer cell lines (MCF-7) revealed that the biofriendly L-tyrosine-capped AgNPs, AuNPs, and bimetallic AgAu NPs were biocompatible. Interestingly, AgAu NPs have also unveiled controlled cytotoxicity, cell viability, and in vitro peroxidase nanozyme activity reliant on metal composition and surface coating. Full article
(This article belongs to the Special Issue Recent Advances in the Construction and Applications of Nanozymes)
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17 pages, 4729 KiB  
Article
One-Pot Synthesis of MnOx-SiO2 Porous Composites as Nanozymes with ROS-Scavenging Properties
by M. Dolores Garrido, Jamal El Haskouri, María D. Marcos, Francisco Pérez-Pla, José Vicente Ros-Lis and Pedro Amorós
Nanomaterials 2022, 12(19), 3503; https://0-doi-org.brum.beds.ac.uk/10.3390/nano12193503 - 07 Oct 2022
Cited by 2 | Viewed by 1532
Abstract
The development of nanomaterials that mimic the activity of enzymes is a topic of interest, for the decomposition of reactive oxygen species (ROS). We report the preparation of a novel nanocomposite of MnOx needles covered with SiO2 porous material. The material [...] Read more.
The development of nanomaterials that mimic the activity of enzymes is a topic of interest, for the decomposition of reactive oxygen species (ROS). We report the preparation of a novel nanocomposite of MnOx needles covered with SiO2 porous material. The material was prepared in one pot with a two-step procedure. The material was characterized by EDX, SEM, TEM, XRD, nitrogen adsorption–desorption isotherms, and XPS. The synthesis protocol took advantage of the atrane method, favoring the nucleation and initial growth of manganese oxide needles that remained embedded and homogeneously dispersed in a mesoporous silica matrix. The final composite had a high concentration of Mn (Si/Mn molar ratio of ca. 1). The nanozyme presented bimodal porosity: intraparticle and interparticle association with the surfactant micelles and the gaps between silica particles and MnOx needles, respectively. The porosity favored the migration of the reagent to the surface of the catalytic MnOx. The nanozyme showed very efficient SOD and catalase activities, thus improving other materials previously described. The kinetics were studied in detail, and the reaction mechanisms were proposed. It was shown that silica does not play an innocent role in the case of catalase activity, increasing the reaction rate. Full article
(This article belongs to the Special Issue Recent Advances in the Construction and Applications of Nanozymes)
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15 pages, 1613 KiB  
Perspective
Unveiling the Potential Role of Nanozymes in Combating the COVID-19 Outbreak
by Jafar Ali, Saira Naveed Elahi, Asghar Ali, Hassan Waseem, Rameesha Abid and Mohamed M. Mohamed
Nanomaterials 2021, 11(5), 1328; https://0-doi-org.brum.beds.ac.uk/10.3390/nano11051328 - 18 May 2021
Cited by 8 | Viewed by 4019
Abstract
The current coronavirus disease 2019 (COVID-19) outbreak is considered as one of the biggest public health challenges and medical emergencies of the century. A global health emergency demands an urgent development of rapid diagnostic tools and advanced therapeutics for the mitigation of COVID-19. [...] Read more.
The current coronavirus disease 2019 (COVID-19) outbreak is considered as one of the biggest public health challenges and medical emergencies of the century. A global health emergency demands an urgent development of rapid diagnostic tools and advanced therapeutics for the mitigation of COVID-19. To cope with the current crisis, nanotechnology offers a number of approaches based on abundance and versatile functioning. Despite major developments in early diagnostics and control of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is still a need to find effective nanomaterials with low cost, high stability and easy use. Nanozymes are nanomaterials with innate enzyme-like characteristics and exhibit great potential for various biomedical applications such as disease diagnosis and anti-viral agents. Overall the potential and contribution of nanozymes in the fight against SARS-CoV-2 infection i.e., rapid detection, inhibition of the virus at various stages, and effective vaccine development strategies, is not fully explored. This paper discusses the utility and potential of nanozymes from the perspective of COVID-19. Moreover, future research directions and potential applications of nanozymes are highlighted to overcome the challenges related to early diagnosis and therapeutics development for the SARS-CoV-2. We anticipate the current perspective will play an effective role in the existing response to the COVID-19 crisis. Full article
(This article belongs to the Special Issue Recent Advances in the Construction and Applications of Nanozymes)
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