Dear Colleagues,

The rational design of innovative nanodevices has opened up endless opportunities to develop the next generation of personalized therapies for patients. Due to their unique physical and chemical properties, nanoparticle-based platforms have emerged as potential tools to improve the pharmacokinetic profiles of conventional therapeutic and diagnostic agents. 

This Special Issue will be focused on the chemical strategies that have recently been developed for the design of engineered nanosystems to achieve the selective and efficient transport of bioactive compounds, ranging from small molecules to biomolecules such as nucleic acids and proteins. Recent developments in the use of nanomaterials as vehicles to administer various therapeutic and/or diagnostic substances, emphasizing the advantages of each specific chemical strategy (e.g., optimal loading, improved half-life and bioavailability) will be reported. In addition, this Issue includes the safety considerations and regulatory issues to carry out the rational design of nanoparticles, as well as preclinical characterization together with challenges and perspectives to be considered in order for nanotherapies to become a reality with diagnostic and therapeutic application. 

In this Special Issue, authors are invited to submit original research articles, reviews, and short communications exploring recent advances in the rational design of chemical strategies to develop diagnostic and/or therapeutic nanodevices and related topics to ensure the clinical translation of nanomedicine. 

Dr. Rosario M. Sanchez-Martin
Dr. Victoria Cano-Cortés
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• nanomedicine
• nanotheranostics
• nanodevices
• rational design
• chemical strategies
• bioconjugation
• encapsulation
• biocompatibility and nanotoxicology
• targeting delivery
• bioimaging
• diagnostic
• therapy
• preclinical characterization
• clinical translation