Selective Chelators for Metals on Cells and Cancer Chemotherapy

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 5562

Special Issue Editor


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Guest Editor
Centro de Química Estrutural, Instituto Superior Técnico - Universidade de Lisboa, Lisbon, Portugal
Interests: organic chemistry; tetrazoles, thiazoles and thiadiazoles; nitrogen ligands; organocatalysis; metal catalysis; selective chelators for metals on biological medium; leads for cancer chemotherapy
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Special Issue Information

Dear Colleagues,

Cancer research continues to be one of the leading banners in medicine and the pharmaceutical sciences. Since this is a topic of great interest to society, the fields of knowledge that act directly in the fight against this disease are numerous and are transversal to different central sciences, such as chemistry, physics or biology. In this context, there are several types of treatments applied for cancer eradication, with chemotherapy procedures leading the way. Besides, the designation of cancer chemotherapy by yourself is quite broad, comprising a large number of medicines and medical practices.

One of the approaches used to combat cancer cell proliferation is based on the application of molecules with chelating / ligand properties, selective for different metals in cell media. In this context, the present special Issue aims to combine a collection of original and review articles comprising basic science, preclinical and clinical discoveries that embrace metal-chelating compounds for cancer chemotherapy.

Dr. Luís M. T. Frija
Guest Editor

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Keywords

  • bioinorganic chemistry
  • cancer chemotherapy
  • metal chelation
  • ligands
  • reactive oxigen species

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Published Papers (1 paper)

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Research

15 pages, 1761 KiB  
Article
Synthesis, Characterization, and Anticancer Activity of Benzothiazole Aniline Derivatives and Their Platinum (II) Complexes as New Chemotherapy Agents
by Md. Kamrul Islam, Ah-Rum Baek, Bokyung Sung, Byeong-Woo Yang, Garam Choi, Hyun-Jin Park, Yeoun-Hee Kim, Minsup Kim, Seongmin Ha, Gang-Ho Lee, Hee-Kyung Kim and Yongmin Chang
Pharmaceuticals 2021, 14(8), 832; https://0-doi-org.brum.beds.ac.uk/10.3390/ph14080832 - 23 Aug 2021
Cited by 14 | Viewed by 4826
Abstract
We describe the synthesis, characterization, molecular modeling, and in vitro anticancer activity of three benzothiazole aniline (BTA) ligands and their corresponding platinum (II) complexes. We designed the compounds based on the selective antitumor properties of BTA, along with three types of metallic centers, [...] Read more.
We describe the synthesis, characterization, molecular modeling, and in vitro anticancer activity of three benzothiazole aniline (BTA) ligands and their corresponding platinum (II) complexes. We designed the compounds based on the selective antitumor properties of BTA, along with three types of metallic centers, aiming to take advantage of the distinctive and synergistic activity of the complexes to develop anticancer agents. The compounds were characterized using nuclear magnetic resonance spectrometry, Fourier transform infrared spectroscopy, mass spectrometry, elemental analysis, and tested for antiproliferative activity against multiple normal and cancerous cell lines. L1, L2, and L1Pt had better cytotoxicity in the liver, breast, lung, prostate, kidney, and brain cells than clinically used cisplatin. Especially, L1 and L1Pt demonstrated selective inhibitory activities against liver cancer cells. Therefore, these compounds can be a promising alternative to the present chemotherapy drugs. Full article
(This article belongs to the Special Issue Selective Chelators for Metals on Cells and Cancer Chemotherapy)
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